Myocardial injury marker in diagnosis of viral myocarditis:a Meta-analysis
LI Yan-zhuo1 XU Lin1▲ ZHANG Qun-hui1,2
1.The Second Ward of Department of Cardiovascular Medicine，Guangzhou General Hospital of Guangzhou Military Command，PLA，Guangdong Province，Guangzhou 510010，China;
2.Graduate School，Guangzhou University of Chinese Medicine，Guangdong Province，Guangzhou 510006，China
Abstract：Objective To assess the myocardial injury marker in clinical diagnosis of viral myocarditis （VMC）.Methods From December 2012 to March 2018，Chinese biomedical literature database （CBM）and China national knowledge network （CNKI）and other databases were searched systematically for the research literature on myocardial injury markers to assist in the diagnosis of VMC.Newcastle-Ottawa Scale （NOS）was used for literature quality evaluation.Results A total of 9 studies were included in this study.The results of meta-analysis indicated that the sensitivity （SEN）of VMC diagnosis was 94%，and the 95%confidence interval was 0.87-0.98，indicating that the rate of missed diagnosis was 6%.The specificity （SPE）was 90%，and the 95%confidence interval was 0.83-0.95，indicating that the misdiagnosis rate was 10%.The positive predictive value was 9.8，and the 95%confidence interval was 5.4-17.7，it indicated that when the myocardial injury markers assist in the diagnosis of VMC was positive，suspicious patients were more likely to be diagnosed with VMC.Negative predictive value was 0.06，it indicated that the possibility of myocardial injury markers excluding suspicious patients as VMC was high.The diagnostic odds ratio was 159，it indicated that myocardial injury markers were 159 times more likely to assist in the diagnosis of VMC positive than negative.The area under the ROC curve was 0.97，it indicated that the diagnostic efficiency was high.Conclusion Myocardial injury marker is indeed valuable in auxiliary diagnosis of viral myoarditis.But much more studies are needed to approve these results.
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