Abstract：Objective To analyze the serum levels of interferon-γ (IFN-γ), interleukin-4 (IL-4), interleukin-10 (IL-10),transforming growth factor-β (TGF-β), and interleukin-17 (IL-17) in patients with respiratory syncytial virus (RSV)bronchiolitis and bronchial asthma (BA).Methods From June 2017 to August 2018, 200 cases of childrens in our hospital were selected as the research object, according to different diseases, they were divided into RSV bronchiolitis group (50 cases) and BA group (50 cases) and non RSV pneumonia group (50 cases), choose the health checkup children for the same period as the control group (50 cases), four groups by enzyme-linked immunosorbent assay (ELISA)method, the levels of IFN-γ, IL-4, IL-10, TGF-β and IL-17 were compared in the four groups.Results The level of IL-17 in the RSV capillary bronchial group was higher than that in the non-RSV pneumonia group, and the difference was statistically significant (P<0.05).Il-17 level in the BA group was higher than that in the non-RSV pneumonia group, and the difference was statistically significant (P<0.05).The levels of IL-10 and TGF-β in the RSV capillary bronchial group were lower than those in the non-RSV pneumonia group (P<0.05).There was no significant difference in IFN-γ between the four groups (P＞0.05).Conclusion RSV bronchiolitis and BA have the same index changes, and RSV bronchiolitis is associated with the expression of inflammatory factors in BA.
杨会兰. 呼吸道合胞病毒毛细支气管炎与支气管哮喘中炎症因子的研究[J]. 中国当代医药, 2019, 26(18): 78-80.
YANG Hui-lan. Study on inflammatory factors in respiratory syncytial virus bronchiolitis and bronchial asthma. 中国当代医药, 2019, 26(18): 78-80.
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