Abstract：[Abstract]Objective To investigate the correlation of olfactory dysfunction with disease stage and dyskinesia of Parkinson′s disease.Methods A total of 50 patients with Parkinson′s disease in our hospital from August 2016 to August 2018 were randomly selected as the Parkinson′s disease group，and 50 health check-ups in our hospital during the same period were randomly selected as the healthy control group.The olfactory recognition threshold（IT）and olfactory perception threshold（DT）of the two groups were detected by five-scent olfaction test solution in a non-odor，ventilated and quiet environment.Then the DT and IT，5 odorants loss of smell in the two groups were analyzed statistically，the correlation between Parkinson′s disease score scale（UPDRS）score and olfactory function of patients with Parkinson′s disease were analyzed.Results The DT and IT of patients with stage 1，1.5，2，2.5 and 3 in the Parkinson′s disease group were higher than the healthy control group（P＜0.05）.The DT and IT of acid，banana，mint，flower fragrance and stench of the Parkinson′s disease group were higher than the healthy control group（P＜0.05）.There were no correlations between UPDRS score，motor function score，DT and IT of patients with Parkinson′s disease（P＞0.05）.The rates of acid，banana，mint，flower fragrance and odor loss of smell of the Parkinson′s disease group（12.0% [6/50]，34.0% [17/50]，46.0% [23/50]，34.0% [17/50]，52.0% [26/50]）were higher than the healthy control group（0.0% [0/50]，2.0% [1/50]，4.0% [2/50]，0.0% [0/50]，2.0% [1/50]）（P＜0.05）.Conclusion The degrees of olfactory dysfunction in Parkinson′s disease patients with different disease stages and dyskinesia are higher than healthy people，however，olfactory dysfunction in patients with Parkinson′s disease has no correlation with disease stage and dyskinesia.
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