Abstract：Objective To explore the influence of different dose of Dexmedetomidine combined with Ropivacaine on brachial plexus block effect.Methods A total of 105 patients with selective upper extremity surgery in our hospital from January to December 2017 were selected as the study subjects,and they were divided into the three groups,and there were 35 cases in each group according to the random number table method.Patients in the observation group 1 were treated with 100 μg Dexmedetomidine combined with 40 ml Ropivacaine (0.375%),patients in the observation group 2 were treated with 50 μg Dexmedetomidine combined with 40 ml Ropivacaine(0.375%),and the control group was treated with 40 ml Ropivacaine (0.375%).The time to block onset,duration of block,pain and analgesia,cortisol concentration,and safety of anesthesia were compared among the three groups.Results The onset time of sensory nerve and motor nerve block in the observation group 1 were shorter than those in the observation group 2 and the control group,and the duration of block in the observation group 1 were longer than those in the observation group 2 and the control group,and the differences were statistically significant(P<0.05).The first pain time and postoperative analgesia time in the observation group 1 were shorter than those in the observation group 2 and the control group,and the first pain score of the observation group 1 was lower than that in the observation group 2 and control group,and the difference was statistically significant(P<0.05).The cortisol concentration at nerve block 10min and at the beginning of the operation in the three groups were significantly higher than those before onset of anesthesia,and the cortisol concentration at nerve block 10 min and at the beginning of the operation in the observation group 1 were lower than those in the observation group 2,and the observation group 2 was lower than those of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions among the three groups (P>0.05).Conclusion Brachial plexus block with 100 mg Dexmedetomidine combined with 40 ml Ropivacaine(0.375%)applied in patients with upper extremity surgery can improve the effect of brachial plexus block,and is safe and effective.It has the advantage of clinical application.
王为库;李仁淑. 不同剂量右美托咪定联合罗哌卡因对臂丛神经阻滞效果的影响[J]. 中国当代医药, 2018, 25(26): 121-124.
WANG Wei-ku;LI Ren-shu. Influence of different dose of Dexmedetomidine combined with Ropivacaine on brachial plexus block effect. 中国当代医药, 2018, 25(26): 121-124.
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