Abstract：Objective To investigate the clinical effect of Oxytocin combined with Misoprostol in preventing postpartum hemorrhage.Methods A total of 120 cases of term vaginal delivery in our hospital were randomly divided into two groups from October 2016 to October 2017,60 cases in each group.The control group was given intramuscular injection of Oxytocin 10 U and intravenous drip of 10 U after delivery,the obseruation group on the basis of the control group,Misoprostol 400 μg plug anus was administered,compared the two groups with the rate of postpartum hemorrhage,the amount of postpartum hemorrhage,the time of the third stage of labor,the changes of blood pressure and heart rate before and after administration.Results The postpartum haemorrhage rate was 1.67%,significantly lower than 15.00%in the control group,significantly less than the control group with 2 h and 24 h,and the differences were statistically significant(P<0.05).The third stage of the observation group was significantly shorter than the control group,and the difference was statistically significant(P<0.05).In the observation group，the systolic blood pressure,diastolic blood pressure and heart rate were significantly decreased compared with the control group,and the differences were statistically significant(P<0.05).There was no significant difference between the two groups in the incidence of nausea,vomiting,cold war,facial flushing,and elevated blood pressure (P＞0.05).Conclusion The clinical effect of Oxytocin combined with Misoprostol on the prevention of postpartum hemorrhage is remarkable.It can effectively shorten the third stage of labor,reduce the amount of postpartum hemorrhage,reduce the rate of postpartum hemorrhage,stabilize hemodynamics,and the adverse reaction is slight,which has positive clinical significance.
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