1.Department of Urology,School of Clinical Medicine (Affiliated Hospital)of Chengdu University of Traditional Chinese Medicine,Sichuan Province,Chengdu 610072,China;
2.Department of Andrology,Chengdu Research Institute of Urology in Sichuan Province,Chengdu 610072,China;
3.Department of Urology,Sichuan Provincial People′s Hospital,Chengdu 610041,China;
4.Department of Andrology,Sichuan Integrative Traditional Chinese and Western Medicine Hospital, Chengdu 610041,China
Abstract：Objective To evaluate clinical efficacy of Tamsulosin combined with Pyridostigmine Bromide treating benign prostatic hyperplasia (BPH)complicated with urinary retention.Methods Totally 60 cases of clinically diagnosed BPH with urinary retention from January 2013 to December 2016 were selected and were randomly assigned to group A(n=30) receiving 0.2 mg of Tamsulosin once a day and group B(n=30)receiving 0.2 mg of Tamsulosin once a day plus 30 mg of Pyridostigmine Bromide,3 times a day for 6 weeks,and patients of two groups were indwelled catheter for one week.Before and after the treatment,IPSS,QOL,OABSS,Qmaxand RV were recorded and evaluated.IPSS,QOL,OABSS,Qmaxand RV before and after the treatment and treatment effect between two groups were compared.Results After 6 weeks medication,the assessable cases were 52 cases including 25 cases in group A and 27 cases in group B.Score of IPSS,QOL and Qmax,RV were improved significantly in both groups(P<0.01).Besides,OABSS score was also statistical difference in group A (P<0.05)and group B (P<0.01)before and after treatment.However,IPSS,Qmaxand RV in group B were significantly improved than those in the group A (P<0.05).There was no significant difference in QOL,OABSS score between two groups(P＞0.05).Conclusion Combination therapy with Tamsulosin and Pyridostigmine Bromide is more effective in the treatment of BPH with urinary retention,and it does not significantly increase OAB symptoms,having good clinical application value．
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