1.Department of Nephrology,Clinical Medical College of Henan University of Science and Technology the First Affiliated Hospital of Henan University of Science and Technology,Luoyang471003,China;
2.Drug Administration Section, Clinical Medical College of Henan University of Science and Technology the First Affiliated Hospital of Henan University of Science and Technology,Luoyang471003,China;
3.Department of Gastroenterology,Clinical Medical College of Henan University of Science and Technology the First Affiliated Hospital of Henan University of Science and Technology,Luoyang471003,China;
4.Department of Ophthalmology,Clinical Medical College of Henan University of Science and Technology the First Affiliated Hospital of Henan University of Science and Technology,Luoyang471003,China
Abstract：Objective To explore the clinical effect and its mechanism of Astragalus Injection combined with Irbesartan in the treatment of hypertensive nephropathy.Methods 94 cases of hypertensive nephropathy and who treated in our hospital from August 2014 to November 2015 were selected,and were divided into the combination group and the control group according to the different treatment methods,47 cases in each group.The control group was treated with Irbesartan alone,while the combination group was treated with Astragalus Injection combined with Irbesartan.Then,after treatment for one month,the changes of blood pressure,renal function,urinary protein of the two groups were compared. Results Diastolic blood pressure and systolic blood pressure after treatment in the two groups was lower than that before treatment,diastolic blood pressure and systolic blood pressure after treatment in the combination group was lower than that in the control group after treatment,with significant difference(P＜0.01).The level of serum cystatin C,SCr,BUN, NAG,α1-MG,24 h urinary protein quantitation after treatment in the two groups was lower than that before treatment, with significant difference(P＜0.05).The level of serum cystatin C,SCr,BUN,NAG,α1-MG,24 h urinary protein quantitation after treatment in the combination group was lower than that in the control group after treatment,with significant difference(P＜0.01).Conclusion The clinical effects of Astragalus Injection combined with Irbesartan in the treatment of hypertensive nephropathy is significant,which the renal function of the patients are restored,and the safety is high.
郭佳音;裴克;朱晶晶;谢琦莲;郭志玲. 黄芪注射液联合厄贝沙坦治疗高血压肾病的效果及作用机制分析[J]. 中国当代医药, 2017, 24(7): 76-78.
GUO Jia-yin1PEI Ke;ZHU Jing-jing;XIE Qi-lian;GUO Zhi-ling. Analysis of the effect and mechanism of action of Astragalus Injection combined with Irbesartan in the treatment of hypertensive nephropathy. 中国当代医药, 2017, 24(7): 76-78.
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