Abstract：Objective To study the effect of Octreotide Acetate Injection combined with Omeprazole Sodium Injection in the treatment of acute pancreatitis.Methods 46 patients with acute pancreatitis admitted into our department from May 2013 to September 2016 were randomly divided into the observation group(n=23)and the control group(n=23).On the basis of routine treatment,the patients in the control group were treated with intravenous drip of Omeprazole Sodium Injection.Patients in the observation group were given continuous intravenous infusion of Octreotide Acetate Injection on the basis of the control group.The remission time of clinical symptoms and physical signs,and the time of laboratory test indicators returning to normal level were compared between two groups.The change of the level of serum C-reactive protein(CRP)and amylase were observed before and after treatment in both groups.The clinical therapeutic effect and incidence rate of complications were compared between the two groups.Results The time of the improvement of clinical symptoms and physical signs and the time of laboratory test indicators returning to normal level in the observation group were significantly shorter than those in the control group(P＜0.01);the level of serum CRP and amylase in the two groups after treatment were significantly lower than those before treatment(P＜0.01),and the level of serum CRP and amylase in the observation group were significantly lower than those in the control group(P＜0.01);the total effective rate was 87.0%in the observation group,and it was significantly higher than that of 60.9%in the control group(P＜0.05).The incidence rate of complications in the observation group was 8.7%,and it was significantly lower than that of 34.8%in the control group(P＜0.05).Conclusion Octreotide Acetate Injection combined with Omeprazole Sodium Injection can significantly improve the therapeutic effect of acute pancreatitis,promote the improvement of symptoms and recovery of the body,and reduce the inflammatory state and pancreatic injury.
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