ObjectiveTo investigate the relationship between waist-height ratio(WHtR)and insulin function in patients withtype 2 diabetes mellitus(T2DM).MethodsOne hundred and eighty cases of T2DM patients were enrolled in the study from January to November in 2016 in Qingdao Endocrine and Diabetes Hospital.They were all received 75 g oral glucose tolerance test or standard bread meal test.Plasma glucose and fasting C-peptide levels were measured at fasting,and after taking glucose or bread meal,plasma glucose and fasting C-peptide levels were measured at 0.5,1,2,3 h. With the cut point of WHtR at 0.5,180 patients were divided into non-obesitygroup and obesity group.The difference in height,weight,blood pressure,blood lipid,beta cell function (HOMA-β),insulin resistance index (HOMA-IR)and so on were compared between two groups.The Pearson correlation analysis and simple linear regression analysis were then made.ResultsThe obesity group had higher weight,WC,HC,BMI,TG,UA,fasting C-peptide,HOMA-β,HOMA-IR,but lower level of HbA1c than non-obesity group,the differences were statistical significance(P<0.05)．Pearson correlation analysis indicated that,WHtR was positively correlated with age,weight,SBP,DBP,WC,HC,BMI,fasting C-peptide,HOMA-β, HOMA-IR(P<0.05),but negatively correlated with height(P<0.01).Simple linear regression analysis revealed that,WHtR was one of main influence factors on HOMA-β and HOMA-IR (P<0.01).ConclusionWHtR maybe a good predict factor for β cell function and insulin resistance.