Abstract： Onjective To exp1ore the effect of memantine hydroch1oride in improving cognitive function and abi1ity of dai1y 1ife of Parkinson disease patients with dementia. Methods 69 Parkinson disease patients with dementia from September 2013 to September 2015 in our hospita1 were se1ected and random1y divided into the contro1 group (n=34) and the observation group (n=35).The contro1 group was treated with donepezi1 hydroch1oride,the observation group was treated with memantine hydroch1oride.The cognitive function,abi1ity of dai1y 1ife and the incidence rate of adverse reaction in the two groups was compared. Results The score of MoCA and MMSE after treatment for 8 and 16 weeks in the observation group was higher than that in the contro1 group,with significant difference (P＜0.05).The exce11ent and good rate of abi1ity of dai1y 1ife in the observation group was 80.0%,which was higher than 55.9% in the contro1 group,with significant difference (P＜0.05).The incidence rate of adverse reaction in the observation group was 1ower than that in the contro1 group,with significant difference (P＜0.05). Conclusion Memantine hydroch1oride in the treatment of Parkinson disease and dementia has good c1inica1 effect,which can obvious1y improve the cognitive function and abi1ity of dai-1y 1ife of patients,and the incidence rate of adverse reaction is 1ow,it is worthy of c1inica1 promotion and app1ication.
严志聪. 盐酸美金刚改善帕金森病痴呆患者认知功能及日常生活能力的效果观察[J]. 中国当代医药, 2016, 23(9): 97-99.
YAN Zhi-cong. Effect observation of memantine hydrochloride in imProving cognitive function and ability of daily life of Parkinson disease Patients with dementia. 中国当代医药, 2016, 23(9): 97-99.
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