Abstract：ObjectiveTo explore the clinical effects of treatment primary nephrotic syndrome by tacrolimus.Methods30 cases clinical data of primary nephrotic syndrome patients in our hospital department of nephrology from February 2011 to March 2015 were selected,and divided into two groups by different treatment methods,the control group（cytoxan compared with prednisone acetate treatment）15 cases and the Tacrolimus group （prednisone acetate compared with tacrolimus treatment）15 cases.The serum albumin,creatinine,cholesterol,triglyceride,urine protein quantitation of two groups primary nephrotic syndrome patients before treatment and after treatment 6 moths were compared,clinical curative effect of two groups primary nephrotic syndrome patients were compared.ResultsThe serum albumin,creatinine, cholesterol,triglyceride,urine protein quantitation of two groups primary nephrotic syndrome patients before treatment were no significant difference(P＞0.05),the serum albumin of control group and Tacrolimus group after treatment 6 moths were higher than before treatment;the creatinine,cholesterol,triglyceride,urine protein quantitation were lower than before treatment;the serum albumin of Tacrolimus group after treatment 6 moths was higher than that of control group;the creatinine,cholesterol,triglyceride,urine protein quantitation were lower than that of control group;the remission rate of treatment group was higher than that of control group,the differences were significant(χ2=7.65，P＜0.05).ConclusionThe clinical symptoms of treatment primary nephrotic syndrome by tacrolimus is obviously,remission rate is high,it is worth to be used.
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