Abstract：Objective To explore the significance of high risk human papillomavirus（HPV）detection and thinprep cytology test（TCT）examination in cervical cancer screening.Methods From January 2013 to December 2015，120 patients suspected cervical cancer were selected as study object，all patients underwent HPV test，TCT and the pathology results as"gold standard".Sensitivity，specificity，accuracy of HPV，TCT in cervical cancer diagnostic were calculated and the diagnosis results of two groups were compared.According to the degree of cervical lesions patients were grouped into CINⅠ，CINⅡ，CINⅢ，cervical cancer，cervical lesions of different HPV viral load were compared.Results Sensitivity，specificity and accuracy of HPV in cervical cancer diagnostic was 96.00%and 73.33%，87.50%respectively，with 84.00%，91.11%and 86.67%respectively of TCT，the sensitivity of HPV was significantly higher than that of TCT （P＜0.05），but the specificity of TCT was significantly higher than that of HPV （P＜0.05），the accuracy of twomethods was considerable（P＞0.05）.HPV viral load in patientswith different degree of cervical lesionswere compared，and the difference was statistically significant（P＜0.05）.Conclusion In the screening of cervical cancer，HPV has high sensitivity，TCT has high specificity，two kinds of inspectionmethods can be combined to reduce themissed diagnosis andmisdiagnosis.
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