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2021 Vol. 28, No. 4
Published: 2021-02-08
 
 
4 Inhibition of angiogenesis in high glucose environment by calcium dobesilate based on zebrafish model and its mechanism study
TANG Zhi-yu；DENG Jie-qiang；WANG Meng；ZUO Ling；WU Jin-xia
Objective To observe the inhibitory effect of calcium dobesilate (CaD) on zebrafish embryos angiogenesis and its mechanism.Methods A total of 180 zebrafish embryos were selected and randomly divided into the blank group,the high glucose group (130 mmol/L glucose),the positive drug+high glucose group,the high glucose+CaD(30 μg/mL) group,the high glucose+CaD (60 μg/mL) group,and the high glucose+CaD (90 μg/mL) group.Among them,the high glucose concentration was 130 mmol/L,and the positive drug was 2 mL endothelial cell growth factor receptor tyrosine kinase inhibitor (VRI) at a concentration of 500 ng/mL.CaD in 2 mL was provided in each CaD group at different concentrations.Three doses of 1/10 maximum non-lethal dose (MNLD,30 μg/mL),1/5 MNLD (60 μg/mL),and 3/10 MNLD (90 μg/mL) were selected as the toxicity indicators with reference to lethality experiment.Drug exposure solution in 2 mL was given for continuous 72 h,which was changed every 24 h.The zebrafish embryonic intersegment blood vessel indexes and the number of fluorescence points were observed and calculated under stereoscopic microscope.Fluorescence quantitative polymerase chain reaction was used to detect the expression of vascular endothelial growth factor (VEGF) and nitric oxide synthase (NOS) in embryos after intervention.The contents of VEGF and NOS were determined by enzyme-linked immuno sorbent assay (ELISA).Results The zebrafish embryonic intersegment blood vessel index,the number of microscopic fluorescence points and the expression levels of VEGF and NOS mRNA in the high glucose group were higher than those in the blank group,and the differences were statistically significant (P＜0.05).The zebrafish embryonic intersegment blood vessel indexes and the number of fluorescence points in the positive drug+high glucose group,the high glucose+CaD (60 μg/mL) group,and the high glucose+CaD (90 μg/mL) group were significantly lower than those in the high glucose group (P＜0.01).The CAD administration groups were compared,the blood vessel indexes of zebrafish embryonic intersegment decreased when the CaD administration dose gradually increased,and the differences were significant (P＜0.05).Compared with the high glucose group,the number of fluorescene points of zebrafish embryos in each group showed a downward trend after drug treatment,and the difference was statistically significant (P＜0.05).The mRNA expression levels of VEGF and NOS in the positive drug+high glucose group,the high glucose+CaD (60 μg/mL)group,and the high glucose+CaD (90 μg/mL) group were lower than those in the high glucose group (P＜0.05).There were no significant differences in the VEGF and NOS mRNA expression between the high glucose+CAD (30 μg/mL)group and high glucose group (P＞0.05).The expression levels of VEGF and NOS in the positive drug+high glucose group,the high glucose+CaD (60 μg/mL) group,and the high glucose+CaD (90 μg/mL) group were lower than those in the high glucose group (P＜0.05).There was no significant difference in the expression of NOS and VEGF between the high glucose+CAD (30 μg/mL) group and high glucose group (P＞0.05).Conclusion CaD can inhibit the angiogenesis of zebrafish embryos in high glucose environment,which is related to the inhibition of VEGF/iNOS.
2021 Vol. 28 (4): 4-7 [Abstract] ( 64 ) HTML (38 KB)  PDF  (0 KB)  ( 8 )
8 Comparison on the application between Dexmedetomidine and Lidocaine in bronchoscopy for patients undergoing tracheal intubation and mechanical ventilation
WANG Yu-liang ;LAI Shao-juan;CUI Zhi-xin;WANG Zhi-qiang
Objective To compare the application between Dexmedetomidine and Lidocaine in bronchoscopy for patients undergoing tracheal intubation and mechanical ventilation.Methods A total of 90 patients with pneumonia underwent tracheal intubation and mechanical ventilation in Hexian Memorial Hospital of Panyu District of Guangzhou City from January 2019 to February 2020 were selected as the research objects,they were divided into the control group (45 cases) and the experimental group (45 cases) according to random number table method.During bronchoscopy,the control group was treated with traditional oxygen-driven Lidocaine atomization surface anesthesia method,while the experimental group was handled with Dexmedetomidine intravenous anesthesia method.The changes of blood pressure,heart rate,finger pulse oxygen at before bronchoscopy (T0),during bronchoscopy (T1) and half an hour after bronchoscopy (T2) and anesthesia effect,the total detection rate of bronchoalveolar lavage fluid culture were compared between the two groups.Results The excellent and good rate of anesthesia in the experimental group was 100.0%,which was higher than 44.4% in the control group,and the difference was statistically significant (P＜0.05).The systolic blood pressure and heart rate of the experimental group at T1 were lower than those of the control group,and the differences were statistically significant (P＜0.05).There was no significant difference in systolic blood pressure and heart rate at T0 and T2 between the two groups (P＞0.05).The systolic blood pressure and heart rate of the control group at T1 were higher than those at T0,and the differences were statistically significant (P＜0.05).There were no significant differences in systolic blood pressure and heart rate in the experimental group at T1 and T2 compared with T0 (P＞0.05).The total detection rate of bronchoalveolar lavage fluid culture of the experimental group was 71.1%,which was higher than 46.6%of the control group,and the difference was statistically significant (P＜0.05).There were no significant differences in the detection rates of Carbapenem-resistant Acinetobacter baumannii and Fungi between the two groups (P＞0.05).Conclusion For conscious patients with pneumonia in ICU undergoing tracheal intubation and mechanical ventilation,the influence on vital signs of Dexmedetomidine intravenous general anesthesia is less than that of Lidocaine atomized surface anesthesia,and the anesthesia effect is better than that of Lidocaine atomized surface anesthesia,and which has less influence on the results of bronchoalveolar lavage fluid culture.
2021 Vol. 28 (4): 8-12 [Abstract] ( 56 ) HTML (43 KB)  PDF  (0 KB)  ( 10 )
13 Characteristics and risk factors analysis of epilepsy related cognitive impairment after acute ischemic stroke
LU Yan
Objective To analyze the characteristics and risk factors of epilepsy related cognitive impairment after acute ischemic stroke,so as to take measures for intervention as early as possible.Methods From January 2017 to January 2020,100 patients with epilepsy after acute ischemic stroke treated in the Second Hospital of Chaoyang were selected and their clinical medical data were analyzed retrospectively.Within one month after the first seizure after acute ischemic stroke,the cognitive function of the patients was assessed by mini mental state examination (MMSE).The patients were divided into cognitive impairment group and non-cognitive impairment group according to the MMSE score.The general data (gender,age,education level,severity of acute ischemic stroke,stroke location,etc.) and laboratory indexes (serum total cholesterol,triglyceride,high density lipoprotein [HDL-C],low density lipoprotein [LDL-C],blood uric acid [UA],etc.) of the two groups were compared.The characteristics of epilepsy related cognitive impairment after acute ischemic stroke were analyzed,and multivariate Logistic regression was used to analyze the risk factors of epilepsy related cognitive impairment after acute ischemic stroke.Results Among the 100 patients,45 (45.00%) patients with cognitive impairment were included in the cognitive impairment group,and 55 (55.00%) patients without cognitive impairment were included in the non-cognitive impairment group.The age,National Institute of Health stroke scale(NIHSS) score,cortical location,multifocal,seizure type (tonic spasm),seizure frequency (≥1 time/d) in the cognitive impairment group were higher than those in the non-cognitive impairment group,the differences were statistically significant (P<0.05).There were no significant differences in gender,education level,body mass index,smoking history,drinking history,cerebral infarction history and basic diseases between the two groups (P>0.05).The levels of serum total cholesterol and hypersensitive C-reactive protein (hs-CRP) in the cognitive impairment group were higher than those in the non-cognitive impairment group,the differences were statistically significant (P<0.05).There were no statistically significant differences in triglyceride,HDL-C,LDL-C,UA,serum creatinine (SCr),blood urea nitrogen (BUN),D-dimer,fibrinogen and homocysteine (Hcy) between the two groups (P>0.05).The results of multivariate Logistic regression analysis showed that age (β=0.656,OR=1.518,95%CI=1.301,2.829),severity of acute ischemic stroke (β=1.470,OR=5.384,95%CI=2.515,11.674),stroke location (β=1.681,OR=6.441,95%CI=2.451,18.568),seizure type(tonic spasm) (β=2.112,OR=7.165,95%CI=1.876,22.417),seizure frequency (≥1 time/d) (β=5.521,OR=11.230,95%CI=4.526,29.813),serum total cholesterol (β=0.704,OR=2.031,95%CI=1.201,3.986) and hs-CRP (β=1.118,OR=3.061,95%CI=1.003,8.754) were the risk factors of epilepsy related cognitive impairment after acute ischemic stroke(P<0.05).Conclusion Patients with epilepsy related cognitive impairment after acute ischemic stroke are older,have higher NIHSS score,have more stroke sites in the cortex,have a wide range of stroke,have more seizure types of tonic spasm,have higher seizure frequency,have higher levels of serum total cholesterol and hs-CRP in laboratory indexes,and the severity of ischemic stroke,the location of the stroke,the type of epilepsy (tonic spasm),the frequency of epilepsy,total serum cholesterol,and hs-CRP are all risk factors that affect its onset,and clinical attention should be paid.
2021 Vol. 28 (4): 13-17 [Abstract] ( 65 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
18 Meta analysis of the effect of physical therapy on dizziness and balance state in mTBI patients
MO Lan-fang
Objective To systematically evaluate the effect of physical therapy on dizziness and balance of patients after mild traumatic brain injury (mTBI).Methods PubMed,Embase,Cochrane Library,EBSCO,Web of Science,Pedro,CNKI,Wanfang,VIP databases were searched to find relevant clinical studies on physical treatment of mTBI.The quality of the included studies was evaluated one by one.And further the scores of the dizziness handicap inventory(DHI),Berg balance scale (BBS),functional Gait assessment (FGA),activities balance confidence scale (ABC) and Gait speed items of the two groups were Meta-analyzed.Results A total of 299 patients in 10 studies were involved in this systematic review.The results showed that the DHI of the treatment group was lower than that of the control group,the difference was statistically significant (P＜0.01);the BBS was higher than that of the control group,the difference was statistically significant (P＜0.01);the FGA was higher than that of the control group,the difference was statistically significant (P＜0.01);ABC level was higher than that of the control group,the difference was statistically significant (P＜0.01);Gait speed level was higher than that of the control group,the difference was statistically significant (P＜0.01).Conclusion Physical therapy can improve the dizziness and balance state of mTBI patients,and promote the patients to return to work and life as soon as possible,thereby improving the patients′ quality of life.
2021 Vol. 28 (4): 18-22 [Abstract] ( 65 ) HTML (42 KB)  PDF  (0 KB)  ( 9 )
23 Research progress in traditional Chinese medicine constitution of prostate disease
LI Jie ;WEI Yong-jin ;SONG Guang-ye;LI Shuai;XU Bo ;OUYANG Hong;DONG Chun-lai
The constitution of traditional Chinese medicine (TCM) is closely related to the occurrence,development,prevention and treatment of diseases.To study further,this article discusses and investigates the relationship between TCM constitutional types and prostate diseases by researching the literature.The current research status of TCM constitution in prostate diseases includes the following points.①Prostatitis is mainly solid constitutions or mixed with solid constitution such as damp-heat,qi-stagnation,etc.②Severe prostate diseases are mainly qi-stagnation or mixed with qi-stagnation constitution.③Prostatic diseases which are prone to erectile dysfunction (ED) are mainly damp-heat,yin-deficiency and yang-deficiency.④The deficiency constitution is most common in prostatic hyperplasia,followed by normal constitution and sluggish constitution.⑤The constitution applied to the prostate diseases: The essence of body differentiation and treatment is to seek its root cause,the main method is that the combination of body differentiation,disease differentiation and syndrome differentiation.In conclusion,this article points out the existing issues of the research and the practical significance of the constitution for the prevention of prostate of occurrence,prevention of progression and prevention of recurrence.
2021 Vol. 28 (4): 23-26 [Abstract] ( 58 ) HTML (40 KB)  PDF  (0 KB)  ( 8 )
27 Research progress of clinic features and imaging of ischiofemoral impingement syndrome
PANG Bo；QIU Li-qin；WANG Lei；TIAN Ying；ZHAO Qi
Ischiofemoral impingement syndrome (IFI) is an atypical extraarticular hip impingement syndrome caused by many factors but not fully understood.It is caused by abnormal femoral muscles due to the stenosis of the sciatic nodule and the small trochanter space.Magnetic resonance imaging (MRI) is the first choice in the diagnosis and evaluation of IFI.Ischiofemoral interstitial injection test has dual value of diagnosis and treatment.Endoscopic decompression appears to be useful in improving function and reducing hip pain in IFI patients.This article reviews the research progress of the anatomy,pathophysiology,clinical manifestation,imaging diagnois and treatment plan of IFI.
2021 Vol. 28 (4): 27-29转33 [Abstract] ( 60 ) HTML (36 KB)  PDF  (0 KB)  ( 10 )
30 Effect of Lidocaine combined with Puerarin infusion on prevention of central venous catheterization-related thrombus
DENG Zhen-zhen ；LIU Shu；ZHOU Jin-feng
Objective To observe the effect of Lidocaine combined with Puerarin infusion on prevention of central venous catheterization-related thrombosis,and to provide the basis for clinical efficacy.Methods A total of 50 inpatient surgical patients from October 2019 to December 2019 in Affiliated Hospital of Jinggangshan University were selected as the study subjects,the patients were divided into the experimental group (25 cases) and the control group (25 cases)according to random number table method.The experimental group received target controlled infusion of 2% Lidocaine at 2 μg/mL and 500 mg Puerarin intravenous drip at the end of operation.The control group received target-controlled infusion of 0.9% normal saline at 2 μg/mL until the end of operation.D dimer levels,hemorheology index,peak venous blood flow velocity,and mean velocity were compared between the two groups.Results The D dimer level and hemorheology index in the experimental group were lower than those in the control group,the peak velocity and average velocity of venous blood flow in the experimental group were higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion Lidocaine combined with Puerarin can reduce early central venous catheterization-related thrombus.
2021 Vol. 28 (4): 30-33 [Abstract] ( 56 ) HTML (34 KB)  PDF  (0 KB)  ( 8 )
34 Application effect of limb rehabilitation training in hemiplegic patients with cerebral hemorrhage
LIU Hai-yan
Objective To explore the application effect of limb rehabilitation training in patients with cerebral hemorrhage hemiplegia.Methods A total of 60 patients with cerebral hemorrhage hemiplegia admitted to Fuzhou First People′s Hospital from January 2018 to April 2020 were selected as the study objects,and they were divided into the control group ( 30 cases） and the observation group ( 30 cases) according to the random single and double number method.The control group received routine nursing,while the observation group received physical rehabilitation training.The psychological status,physical function and quality of life of the two groups were compared.Results The adverse psychological score of the observation group at 3 and 6 weeks after intervention were lower than those of the control group,and the differences were statistically significant (P＜0.05).The adverse psychological scores of the two groups at 3 and 6 weeks after intervention were lower than those before intervention (P＜0.05).The adverse psychological scores in the two groups at 6 weeks after intervention were lower than those at 3 weeks after intervention (P＜0.05).There was no significant difference in limb function score between the two groups before intervention (P＞0.05).The limb function scores of the observation group at 3 and 6 weeks after intervention were higher than those of the control group (P＜0.05).The limb function scores of the two groups at 3 and 6 months after intervention were lower than those before intervention(P＜0.05).The limb function score of the two groups at 6 weeks after intervention was lower than that at 3 weeks after intervention (P＜0.05).There was no significant difference in the scores of quality of life between the two groups before intervention (P＞0.05).The quality of life score of the observation group after 4 weeks of intervention was higher than that of the control group,and the difference was statistically significant (P＜0.05).The scores of quality of life in the two groups after 4 weeks of intervention were higher than those before intervention,and the differences were statistically significant (P＜0.05).Conclusion Physical rehabilitation training for patients with cerebral hemorrhage hemiparalysis can effectively improve the effect of intervention,limb function and quality of life,reduce adverse psychology,has clinical application value.
2021 Vol. 28 (4): 34-36转40 [Abstract] ( 50 ) HTML (33 KB)  PDF  (0 KB)  ( 10 )
37 Effect of different doses of Vitamin C on inflammation indexes and severity of disease in patients with pulmonary infectivity of sepsis
LI Wen-long ；DENG Jia-qian ；ZHONG Zhen-zhou

Objective To explore the effect of different doses of Vitamin C on the inflammatory indexes and severity of the patients with pulmonary infectivity of sepsis.Methods The clinical data of 82 patients with pulmonary infectious sepsis admitted to Ganzhou People′s Hospital from February 2017 to December 2019 were retrospectively analyzed.The patients were divided into group A and group B according to the different doses.Patients who received low-dose vitamin C were enrolled in group A (40 cases),and patients who received high-dose Vitamin C were enrolled in group B(42 cases).The central venous pressure (CVP),serum index (lactic acid and vitamin C [VitC]),inflammation indexes (Creactive protein [CRP]and procalcitonin [PCT]),acute physiology and chronic health status scale Ⅱ (APACHE Ⅱ)scores and central venous oxygen saturation (ScvO2) levels were compared between the two groups before treatment and after 7 days of treatment.Results Compared of CVP,serum VitC,lactate level,CRP,PCT,APACHE Ⅱscore,ScvO2 between the two groups before treatment,and the comparison of CVP,serum VitC,lactate levels,CRP,PCT,APACHEⅡ,ScvO2 between the two groups after 7 days of treatment,the differences were not statistically significant (P>0.05).After 7 days of treatment,the levels of CVP,serum VitC and ScvO2 in both groups were higher than those before treatment,and the scores of lactic acid,CRP,PCT and APACHE Ⅱwere lower than those before treatment,and the differences were statistically significant (P<0.05).Conclusion Vitamin C adjuvant therapy for patients with pulmonary infectivity of sepsis can increase the VitC content in the body,correct the patient′s hypotension and acidosis,reduce the body′s inflammatory response level,improve the patient′s blood oxygen content and lung function,reduce the severity of the disease,and the effect of large or small doses is equivalent.
2021 Vol. 28 (4): 37-40 [Abstract] ( 56 ) HTML (33 KB)  PDF  (0 KB)  ( 8 )
41 Effect comparison of ultrasound-guided upper arm infusion port and thoracic infusion port in tumor chemotherapy patients
JIANG Wen-chuan；JIANG Ya-lan；LIANG Su-fang
Objective To explore the effect comparison of ultrasound-guided upper arm infusion port and thoracic infusion port in tumor chemotherapy patients.Methods A total of 100 tumor chemotherapy patients who needed to be implanted into the infusion port in Jiangmen Central Hospital from October 2018 to October 2019 were selected as the research subjects.They were divided into the control group (50 cases) and the observation group (50 cases) according to a random lottery method.The control group adopted a chest-type infusion port implantation treatment method,the observation group adopted an upper arm infusion port implantation treatment method.The total incidence of complications,postoperative comfort,the success rate of one needle placement,the incidence of vascular injury,and the rate of intraoperative hematoma formation of the two groups were compared.Results The total incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant (P<0.05).The comfort scores of the observation group at 1 day,1 week,and 1 month after surgery were lower than those of the control group,and the comfort scores of the two groups at 1 week and 1 month after operation were lower than those of the control group 1 day after operation,the differences were statistically significant (P<0.05).The success rate of one-needle placement in the observation group was higher than that in the control group,and the incidence of vascular injury and intraoperative hematoma formation were lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion Ultrasound-guided upper arm infusion port has high safety in cancer chemotherapy patients,and has high postoperative comfort,high success rate of one-needle placement,while has low incidence of vascular injury and intraoperative hematoma formation,clinical application value is high.
2021 Vol. 28 (4): 41-43转47 [Abstract] ( 53 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
44 Effect of hypertonic sodium chloride solution in the treatment of hemorrhagic shock
WANG Jing
Objective To investigate the effect of hypertonic sodium chloride solution in the treatment of hemorrhagic shock. Methods A total of 82 patients with hemorrhagic shock admitted to Shenyang Medical College from November 2018 to November 2019 were selected as the research objects.According to the random number table,they were divided into the control group (41 cases) and the observation group (41 cases).The control group was treated with conventional treatment,the observation group was treated with hypertonic sodium chloride solution on the basis of conventional treatment.The blood transfusion volume,total transfusion volume,resuscitation time,hemoglobin concentration,blood pressure and heart rate,serum nitric oxide (NO),integrin β2-chain (CD18) content,complications,and death were compared between the two groups. Results The blood transfusion and total infusion of the observation group were less than those of the control group,and the recovery time of the observation group was shorter than that of the control group,the differences were statistically significant (P＜0.05).The hemoglobin concentration and blood pressure of the observation group after treatment were higher than those of the control group,the heart rate of the observation group after treatment was lower than that of the control group,the differences were statistically significant (P＜0.05).The levels of serum NO and CD18 of the observation group after treatment were lower than those in the control group,the differences were statistically significant (P＜0.05).The total incidence of complications and mortality in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05). Conclusion The application of hypertonic sodium chloride solution in the treatment of patients with hemorrhagic shock can help reduce blood transfusion,shorten recovery time,increase hemoglobin concentration and blood pressure,reduce complications,and help stabilize vital signs and improve prognosis.
2021 Vol. 28 (4): 44-47 [Abstract] ( 65 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
48 Effect of Dopamine and Phentolamine in emergency severe pneumonia with heart failure
LU Jian-guang
Objective To analyze the effect of Dopamine and Phentolamine in emergency severe pneumonia with heart failure.Methods A total of 54 children with severe pneumonia complicated with heart failure treated in the Hospital of Shunyi District of Beijing from February 2018 to February 2020 were selected as the research subjects.According to random number table method,they were divided into control group (27 cases) and experimental group (27 cases).The control group was treated with Dopamine,and the experiment group was treated with the combination of Dopamine and Phentolamine.The clinical total effective rates,inflammatory factor levels and cardiac functions of the two groups were compared.Results The total effective rate of the experiment group was higher than that of the control group,with statistically significant difference (P<0.05).Before treatment,the differences of C-reactive protein (CRP),tumor necrosis factor α (TNF-α),interleukin-6 (IL-6) levels between the two groups were not statistically significant (P>0.05).After treatment,the levels of CRP,TNF-α and IL-6 in the two groups were lower than those before treatment,while the levels of CRP,TNF-α and IL-6 in the experimental group were lower than those in the control group,with statistically significant differences (P<0.05).After treatment,the heart rate and left ventricular end diastolic diameter of the two groups were lower than those before treatment,and the left ventricular ejection fraction was higher than that before treatment,and the differences were statistically significant (P<0.05).Heart rate and left ventricular end diastolic diameter in experimental group were lower than those in control group,and left ventricular ejection fraction was higher than that in control group,with statistically significant differences (P<0.05).Conclusion Dopamine and Phentolamine was more effective than monotherapy in the treatment of emergency severe pneumonia with heart failure.
2021 Vol. 28 (4): 48-50 [Abstract] ( 56 ) HTML (30 KB)  PDF  (0 KB)  ( 10 )
51 Clinical effect on the treatment of open wound of tendon of hand and foot with artificial dermis combined with autologous blade-thick skin graft
SONG Hao-hao；ZHANG Yi-geng； LIU Chun； WANG Shuai； HU Jian-wei；ZHANG Yue-ming
Objective To explore the clinical effect of the combination of artificial dermis and autologous blade-thick skin graft on the treatment of exposed hand-foot-tendon wounds,so as to provide more reasonable and effective treatment solutions.Methods A total of 50 patients with exposed hand-foot-tendon wounds admitted to the Department of Orthopedic of Tangshan Gongren Hospital from January 1,2018 to January 1,2020 were selected as study subjects.With October 1,2019 as the limit,they were divided into the control group and the observation group,with 25 cases in each group.After their admission,all patients obtained the routine dressing change for the preparation of the wound.When the wound surface was cleaned and reached the skin grafts conditions,the patients in control group performed the simple autologous skin flap transplantation,while the patients involved in observation group were given artificial dermis to cover the wound in the first stage,and then 2 weeks later,they accepted the autologous brade-thick skin graft.Subsequently,the postoperative efficacy of the two groups was compared after the wound was healed.Results The wound healing time of patients in the observation group was longer than that of the control group,and the healing time of donor site was shorter than that of the control group,and the differences were statistically significant (P<0.05).The scores of Vancouver scar scale (VSS) in observation group were lower than those in control group at 3 and 6 months after wound healing,and the differences were statistically significant (P<0.05).The VSS score of observation group at 6 month after wound heal in the donor site was lower than that of the control group,and the difference was statistically significant (P<0.05).The VSS scores of the two groups at 6 months after wound healing were lower than those at 3 months after wound healing,and the differences were statistically significant (P<0.05).The total satisfaction in the observation group was higher than that in the control group,and the difference was statistically significant (P<0.05).The incidence of deformity in observation group was lower than that in control group,and the difference was statistically significant (P<0.05).Conclusion It is preliminarily believed that,compared with the autologous skin flap transplantation,the overall treatment effect of artificial dermis with autologous blade-thick skin graft treatment is better for patients developing with exposed hand-foot-tendon wounds,and the surgery is simpler and easier to be operated,thus indicating the lowest risk.Therefore,it deserves to be promoted clinically.
2021 Vol. 28 (4): 51-54 [Abstract] ( 61 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
55 Effect of self-efficacy theory intervention to functional exercise compliance of home-dwelling stroke patients
SHANG Yan-ping1 HUANG You-mei2 CAO Xiao-xia3 SUN Yu-guang；LI Yan-fen；LI Hui-mei；HUANG Wei-tian；GUO Ying； JIA Jing
Objective To discuss the effect of self-efficacy theory intervention to functional exercise compliance of home-dwelling stroke patients.Methods A total of 60 stroke who were discharged home after rehabilitation at Guangdong Work Injury Rehabilitation Hospital from July 1,2019 to March 31,2020 were selected as study subjects.They were divided into the experimental group (30 cases) and the control group (30 cases) according to the random number table method.The control group was given conventional discharge rehabilitation guidance based on personalized condition,the experiment group added the self-efficacy theory intervention plan.The scores of patients′ self-efficacy and functional exercise compliance assessed by rehabilitation self-efficacy scale and functional exercise compliance scale before intervention and at the 4,8 and 12 weeks after intervention were compared.Results There were no significant differences in rehabilitation self-efficacy and functional exercise compliance scale scores between the two groups before intervention (P>0.05).The patients in the experimental group had higher rehabilitation self-efficacy and functional exercise compliance scale scores at 4,8 and 12 weeks after intervention than those in the control group,the differences were statistically significant (P<0.05).Conclusion The intervention plan which is based on self-efficacy theory construction can greatly improve the home functional exercise compliance of cerebral stroke patients.
2021 Vol. 28 (4): 55-58转62 [Abstract] ( 60 ) HTML (39 KB)  PDF  (0 KB)  ( 9 )
59 Application effect of family token system in attention deficit hyperactivity disorder children
KONG Ni-na ；ZHAO Hong-wei
Objective To explore the application effect of family token system in attention deficit hyperactivity disorder children.Methods A total of 80 children with attention deficit hyperactivity disorder treated in the Department of Psychology,Shenyang Children′s Hospital from January to April 2020 were selected as the research subjects.According to random paper method,they were divided into control group and observation group,with 40 cases in each group.The routine rehabilitation of control group were used,the family token system of observation group were used.The attention deficit hyperactivity disorder rating scale scares,reaction control and comprehensive attention were compared before and after intervention in the two groups,and the clinical efficacy of children in the two groups was compared.Results After intervention,the attention,hyperactivity and impulse scores of children in the two groups were lower than those before intervention,and the response control and comprehensive attention scores were higher than those before intervention,the differences were statistically significant (P<0.05).The attention,hyperactivity and impulse score of children in observation group after intervention were lower than those of the control group,the reaction control and comprehensive attention were higher than those of the control group,the total clinical effective rate of children with attention deficit hyperactivity disorder in the observation group was higher than that of the control group,the differences were statistically significant (P<0.05).Conclusion The application of family token system in attention deficit hyperactivity disorder children,which could improve clinical system of children,increase attention and reaction control,the effect is obvious,it is worth to be used.
2021 Vol. 28 (4): 59-62 [Abstract] ( 63 ) HTML (34 KB)  PDF  (0 KB)  ( 9 )
63 Clinical effect of Ziprasidone Intramuscular Injection in the treatment of acute schizophrenia
CHEN Yu-hong
Objective To study the clinical effect of Ziprasidone intramuscular injection in the treatment of acute schizophrenia.Methods A total of 120 patients with acute schizophrenia admitted to the Fourth People′s Hospital of Yingkou City from December 2017 to December 2019 were selected as the research subjects.According to the random number table method,they were divided into control group (60 cases) and research group (60 cases).The control group was treated with Haloperidol Injection,and the research group was treated with Ziprasidone Injection.The positive and negative symptom scale scores (PANSS),the total clinical effectiveness rate and the total incidence of clinical adverse reactions of the two groups before treatment and 72 hours after treatment were tested.Results The total score of PANSS,positive factor score,negative factor score and general psychopathological factor score of the two groups after treatment were lower than those before treatment,and the differences were statistically significant (P<0.05).The total score of PANSS,positive factor score,negative factor score and general psychopathological factor score before treatment between the two groups were compared,and the differences were not statistically significant (P>0.05).The total score of PANSS,positive factor score,negative factor score and the incidence of adverse reactions of the research group after treatment were all lower than those in the control group,and the differences were statistically significant (P<0.05).There was no statistical significance in the general psychopathological factor scores between the two groups after treatment (P>0.05).The total clinical effectiveness rate of the research group was higher than that in the control group,and the difference was statistically significant (P<0.05).Conclusion Ziprasidone Injection has obvious clinical efficacy and high safety in patients with acute schizophrenia.Compared with Haloperidol Injection,the incidence of adverse reactions is lower,which is worthy of clinical reference.
2021 Vol. 28 (4): 63-65转69 [Abstract] ( 51 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
66 Efficacy and safety of Aspirin and Clopidogrel in the treatment of acute cerebral infarction
GUO Hong-yan
Objective To investigate the effect and adverse reactions of Aspirin combined with Clopidogrel in the treatment of acute cerebral infarction.Methods A total of 102 patients with acute cerebral infarction admitted to the Iron and Coal General Hospital of Liaoning Health Industry Group from December 2018 to January 2020 were selected as the research subjects.According to the random number table method,they were divided into observation group (51 cases)and control group (51 cases).The control group was treated with Aspirin while the observation group was treated with Aspirin and Clopidogrel.After treatment,the total effective rate,the National Institutes of Health Stroke Scale (NIHSS)score,the health status questionnaire(SF-36)scores,hemorheology indexes and adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than that of control group,the difference was statistically significant (P<0.05).There were no significant differences in NIHSS and SF-36 scores between the two groups before treatment (P>0.05).After treatment,the NIHSS scores of the two groups were lower than those before treatment,and the SF-36 scores were higher than those before treatment,the differences were statistically significant (P<0.05).The NIHSS score of the observation group after treatment was lower than that of the control group,and the SF-36 score was higher than that of the control group,and the differences were statistically significant (P<0.05).The red blood cell aggregation index of the observation group was lower than that of the control group,the plasma viscosity,the low shear viscosity of whole blood,the maximum platelet aggregation induced by arachidonic acid the rate of platelet aggregation (MARAA) and the maximum platelet aggregation rate (MARADP) induced by adenosine diphosphate were higher than those of the control group,and the differences were statistically significant (P<0.05).Comparison of total incidence of adverse reactions between two groups,the difference was not statistically significant (P>0.05).Conclusion The use of Aspirin combined with Clopidogrel in the treatment of patients with acute cerebral infarction can effectively improve blood circulation and nerve function,improve clinical symptoms,and contribute to the improvement of patients′ quality of life,which is of development value.
2021 Vol. 28 (4): 66-69 [Abstract] ( 55 ) HTML (32 KB)  PDF  (0 KB)  ( 9 )
70 Effect of different initial dose of Paricalcitol in the treatment of secondary hyperparathyroidism
WEI Pei-dan；JIA Chen；CHEN Xiao XU；Shi-zhang ；YI Jian-wei ；LUO Zi-yun； HE Zhi-hong
Objective To investigate the effect of different initial dose of Paricalcitol in the treatment of secondary hyperparathyroidism (SHPT).Methods A total of 80 patients with hemodialysis and SHPT who admitted to Yichun People′s Hospital of Jiangxi Province from August 2018 to August 2019 were selected as the research objects and divided into the control group,small-dose group,moderate-dose group and large-dose group according to the random number table method,with 20 cases in each group.The control group was treated with placebo,small-dose group was treated with initial dose of 0.04 μg/kg Paricalcitol,moderate-dose group was treated with initial dose of 0.08 μg/kg paricalcitol,and large-dose group was treated with initial dose of 0.1 μg/kg Paricalcitol.After 3 months of treatment,the efficacy,qualified rate of intact parathyroid hormone (iPTH) and the adverse reactions were compared among the four groups.Results After treatment,the total effective rate of moderate-dose group was higher than those of the control group,small-dose group and large-dose group,and the differences were statistically significant (P<0.05).The qualified rate of iPTH in moderate-dose group was higher than those of the control group,small-dose group and large-dose group,and the differences were statistically significant (P<0.05).There were no statistically significant differences in the incidence of adverse reactions of the small-dose group,moderate-dose group and large-dose group (P>0.05).Conclusion The moderate initial dose of Paricalcitol (0.08 μg/kg) for patients with hemodialysis and SHPT has better curative effect and higher qualified rate of iPTH,and not increase the risk of adverse reactions.
2021 Vol. 28 (4): 70-72 [Abstract] ( 56 ) HTML (30 KB)  PDF  (0 KB)  ( 8 )
73 Application of percutaneous multi-angle oblique puncture renal biopsy under ultrasound guidance
WU Yi-qiang； CHEN Xie-hong； WU Geng-mao
Objective To explore the application safety and advantages of percutaneous multi-angle oblique puncture under ultrasound guidance in renal biopsy.Methods A total of 388 patients who underwent renal puncture in Jieyang People′s Hospital from June 2014 to December 2019 were selected as the research objects,and 72 patients who underwent renal puncture with a fixed-angle stent from June 2014 to April 2015 were selected as the control group (vertical puncture insertion),from May 2015 to December 2019,316 patients undergoing renal puncture with a variable-angle puncture stent were used as the experimental group.The experimental group was divided into group A (15°,132 cases),group B (25°,91 cases),group C (35°,56 cases),and group D (45°,37 cases) according to the puncture angle.The puncture success rate,specimen qualification rate,specimen length,glomerulus number,the incidence of postoperative urinary erythrocytosis,the incidence of perirenal hematoma,and the incidence of gross hematuria between the experimental group and the control group and among different groups in the experimental group were compared.Results The puncture success rate of the experimental group and the control group was 100.0%.The specimen qualification rate,specimen length and glomerulus number in the experimental group were higher than those in the control group,and the differences were statistically significant (P<0.05).There were no significant differences in the incidence rates of postoperative urinary erythrocytosis,gross hematuria,perirenal hematoma at 0 and 72 h after operation between the experimental group and the control group(P>0.05).There were no significant differences in the specimen qualification rate,specimen length,glomerulus number,the incidence rates of postoperative urinary erythrocytosis,gross hematuria,perirenal hematoma at 0 and 72 h after operation among different groups in the experimental group （P>0.05）.Conclusion The application of multi-angle oblique puncture and individualized puncture angles can significantly increase the number of glomeruli obtained from puncture biopsy specimens without increasing the bleeding complications of puncture biopsy.
2021 Vol. 28 (4): 73-77 [Abstract] ( 58 ) HTML (44 KB)  PDF  (0 KB)  ( 7 )
78 Effect of percutaneous nephrostomy in the treatment of upper urinary calculi complicated with urinary sepsis
CHEN Jing-ru ；LIAO Zheng-quan； CHEN Jun-wu
Objective To explore the clinical effect of percutaneous nephrostomy in the treatment of upper urinary calculi complicated with urinary sepsis.Methods A total of 80 cases of patients with upper urinary calculi complicated with urinary sepsis from May 2018 to May 2020 in the First People′s Hospital of Yidu were selected as research objects and divided into two groups according to the random number table method,40 cases in each group.The observation group was treated with percutaneous nephrostomy,and the control group was treated with ureteral stent implantation.Then the changes of serum endotoxin level were compared between the two groups before and after treatment.The levels of inflammatory factors before and 3 days after treatment were recorded.The time of body temperature recovery,time of leukocyte recovery and hospitalization time were observed and the incidence of complications was counted in the two groups.Results At 1 and 3 days after treatment,the levels of serum endotoxin in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).At 3 days after treatment,the levels of tumor necrosis factor-α (TNF-α) and high sensitivity C-reactive protein (hs-CRP) in the observation group were lower than those in the control group,and the differences were statistically significant (P<0.05).The time of body temperature recovery,time of leukocyte recovery and hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant (P<0.05).The total incidence of hematoma at the puncture site,renal failure and catheter obstruction in the observation group was lower than that in the control group,and the difference was statistically significant (P<0.05).Conclusion Percutaneous nephrostomy for patients with upper urinary calculi complicated with urinary sepsis can effectively reduce endotoxin level,control inflammatory reaction and shorten hospitalization time,so it has few complications and high safety.
2021 Vol. 28 (4): 78-81 [Abstract] ( 40 ) HTML (33 KB)  PDF  (0 KB)  ( 6 )
82 Application of Shenkang Injection in the treatment of peritoneal dialysis patients
KONG Ai-li ；QIU Xiao-ling
Objective To explore the application effect of Shenkang Injection in the treatment of Peritoneal dialysis patients.Methods A total of 40 patients with peritoneal dialysis treated in Huludao Central Hospital from October 2016 to October 2019 were selected and randomly divided into the control group (20 cases) and the study group (20 cases) by lottery,all the patients in the two groups were given peritoneal peritoneal dialysis treatment,on this basis,the patients in the study group were treated with Shenkang Injection.Both groups were treated for 4 weeks.The changes of indexes which included residual renal function,anaemia indexes,the levels of serum protein and the trace elements(calcium and phosphorus) were compared.Results After treatment 4 weeks,the glomerular filtration rate(GFR) of residual renal in the study group was higher than that in the control group,the anaemia indexes,the levels of protein and calcium in the study group were higher than those in the control group,the level of phosphorus in the study group was lower than that in the control group,the differences were statistically significant (P＜0.05);the reduces of residual renal function in the control group at treatment for 4 weeks was lower than that before treatment (P＜0.05).No obvious adverse reactions were observed in the two groups during the treatment.Conclusion Shenkang Injection is effective in the treatment of peritoneal dialysis,which can improve the residual function and nutritional status of patients,and it has good safety.
2021 Vol. 28 (4): 82-85 [Abstract] ( 67 ) HTML (36 KB)  PDF  (0 KB)  ( 10 )
86 Therapeutic effect of combined laparoscopic choledochoscopy on hepatobiliary calculi
LIANG Hui；YANG Long；XIE Li-hua
Objective To explore the effect of laparoscopic choledochoscopy in the treatment of hepatobiliary calculi.Methods A total of 96 patients with hepatolithiasis admitted to the second Affiliated Hospital of Nanchang University from May 2017 to June 2019 were selected as the research objects.According to difference of the operation treatment,they were divided into control group (48 cases) and combined group (48 cases).The control group was treated with traditional open surgery,and the combined group was treated with laparoscopy and choledochoscopy.The operation situation,complication rate and treatment effect of the two groups were compared.Results The operation time,exhaust time,incision and hospitalization time of the combined group were shorter than those of the control group,and the amount of bleeding during the operation was less than that of the control group,the differences were statistically significant (P<0.05).The total incidence of biliary fistula,biliary tract infection,stone residue and biliary bleeding in the combined group was lower than that in the control group (P<0.05),and the total effective rate of treatment in the combined group was higher than that in the control group,the difference was statistically significant (P<0.05).Conclusion Compared with traditional laparotomy,laparoscopic and choledochoscopy treatment for patients with hepatobiliary calculi can improve the surgical effect,reduce the incidence of complications,and ensure the safety of the treatment.It is worthy of popularization and use.
2021 Vol. 28 (4): 86-88 [Abstract] ( 55 ) HTML (31 KB)  PDF  (0 KB)  ( 9 )
89 Influence of different carbon dioxide pneumoperitoneum pressure on the incidence and degree of pain after laparoscopic appendectomy
YE Yong-qing；ZHOU Zhi-jian；YE Min
Objective To investigate the influence of different carbon dioxide (CO2) pneumoperitoneum pressure on the incidence and degree of pain after laparoscopic appendectomy (LA).Methods A total of 90 patients with acute appendicitis who treated in Shangrao Hekang Hospital CO.,Ltd.from January 2018 to December 2019 were selected as the research subjects,and they were divided into three groups according to random number table method,30 cases in each group.All three groups underwent same surgical procedure.group A maintained CO2 pneumoperitoneum pressure of 10 mmHg,group B maintained CO2 pneumoperitoneum pressure of 12 mmHg,and group C maintained CO2 pneumoperitoneum pressure of 15 mmHg.The operation time,postoperative pain and complications were compared among the three groups.Results There was no statistical difference in the operation time and the incidence of postoperative complications among the three groups (P＞0.05).The incidence and degree of postoperative pain in group A were lower than those in group B and group C within 12 h after surgery,and the differences were statistically significant (P<0.05).Conclusion The CO2 pneumoperitoneum pressure is correlated with the pain after LA.LA under low CO2 pneumoperitoneum pressure has no significant effect on surgical operation.Low CO2 pneumoperitoneum pressure can alleviate the pain after LA,which provides basis for choosing pneumoperitoneum pressure in clinical LA.
2021 Vol. 28 (4): 89-90 [Abstract] ( 58 ) HTML (34 KB)  PDF  (0 KB)  ( 7 )
92 Application of sequential electrohydraulic lithotripsy in choledocholithiasis after bimirror combined with common bile duct exploration
JI Lai-wei ；SUN Duo； SONG Duo ；JIANG De-shuai
Objective To explore the effect of sequential electrohydraulic lithotripsy after bimirror combined with common bile duct exploration on the one-time caculus removal rate and recovery of patients with choledocholithiasis.Methods A total of 67 patients with choledocholithiasis treated in Shenyang Fourth People′s Hospital,Liaoning Province from February 2019 to February 2020 were selected as the research objects.According to the random number table method,they were divided into control group (33 cases) and an observation group (34 cases).The control group adopted bimirror combined with common bile duct exploration method,the observation group adopted sequential electrohydraulic lithotripsy after bimirror combined common bile duct exploration.The one-time caculus removal rate,white blood cell count (WBC),total bilirubin (TBil),glutamyl transpeptidase (GGT) levels improvement and complications were compared between the two groups.Results The operations in the two groups were successfully completed and the caculus removal rate was 100%;the intraoperative blood loss of the observation group was less than that of the control group,and the time of operation,biliary bleeding,exhaust and hospitalization time were shorter than those of the control group,the differences were statistically significant (P<0.05);the WBC,TBil,and GGT levels of the observation group after surgery were lower than those of the control group,the differences were statistically significant (P<0.05);the total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant (P<0.05).Conclusion Sequential electrohydraulic lithotripsy after bimirror combined with common bile duct exploration for patients with choledocholithiasis has a significant effect,which can completely remove the calculus and decrease WBC,TBil levels,and there is no obvious increase in complications,and is worth learning from.
2021 Vol. 28 (4): 92-94转98 [Abstract] ( 44 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
95 Clinical effect of sphincter preservation surgery treating anal fistula
ZONG Yi ；CHEN Hua ；ZHOU Yan； JIANG Yu-xin ；ZHENG Wei-qin ；PENG Fan-ping
Objective To explore the clinical effect of sphincter preservation surgery treating anal fistula.Methods Fifty patients with anal fistula admitted to Fuyong People′s Hospital of Bao′an District in Shenzhen City from January 2017 to July 2019 were selected as the research objects.They were divided into control group (25 cases) and study group(25 cases) according to the random grouping method.The control group was treated with one-time incision and threaddrawing,the study group adopted the surgical treatment method of preserving the sphincter to preserve the mucosa.The one-time cure rates,anal pain,anal edema scores after surgery,incidence of complications,surgical operation time and hospitalization time were compared between the two groups.Results The one-time cure rate of the study group was higher than that of the control group,and the difference was statistically significant (P<0.05).The postoperative anal pain score and marginal edema score of the study group were lower than those of the control group,the differences weretatistically significant (P<0.05),the total incidence of postoperative complications in the study group was lower than that in the control group,and the operation time and postoperative hospital stay were shorter than those of the control group,the differences were statistically significant (P<0.05).Conclusion The implementation of the treatment plan of sphincter preserving sphincter in the treatment of anal fistula patients can effectively improve the quality of the operation and the treatment effect,alleviate the discomfort of the patients after surgery,reduce the incidence of postoperative complications,and optimize the surgical procedure,shorten the treatment and hospitalization time,which is worth promoting and applying.
2021 Vol. 28 (4): 95-98 [Abstract] ( 48 ) HTML (33 KB)  PDF  (0 KB)  ( 11 )
99 Effect of laparoscopic surgery on immune function and serum interleukin-8 and tumor necrosis factor-α levels in patients with acute suppurative appendicitis
DU Jian； WANG Jiang ；WANG Shu ；SONG Cheng-fei

Objective To explore the effect of laparoscopic surgery on immune function and serum levels of interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in patients with acute suppurative appendicitis.Methods A total of 89 patients with acute suppurative appendicitis treated in Liaoning Health Industry Group Fukuang General Hospital from February 2018 to October 2019 were selected，and divided into the control group (n=44) and the observation group(n=45) by the random number table method.The control group underwent routine laparotomy,and the observation group underwent laparoscopic surgery.The clinical indicators were compared between the two groups,and the immune function,serum IL-8,and TNF-α levels before and 72 h after operation were compared between the two groups.Results The incision length and exhaust time of the observation group were shorter than those of the control group,and the amount of bleeding was less than that of the control group at 72 h after operation;at 72 h after operation,the serum levels of immunoglobulin M (IgM) and immunoglobulin G (IgG) in the two groups were lower than those before operation,and the serum IgM and IgG levels in the observation group were higher than those in the control group at 72 h after operation;at 72 h after operation,the levels of serum IL-8 and TNF-α in the two groups were lower than those before operation,and the levels of serum IL-8 and TNF-α in the observation group were lower than those in the control group at 72 h after operation,the differences were statistically significant(P<0.05).Conclusion Laparoscopic surgery has a significant effect on the treatment of acute suppurative appendicitis,which can improve the patient′s immune function,reduce the serum IL-8 and TNF-α levels，inhibit the body′s inflammatory response,and promote the patient′s recovery.
2021 Vol. 28 (4): 99-101 [Abstract] ( 59 ) HTML (30 KB)  PDF  (0 KB)  ( 6 )
102 Influence of whether or not the first operation of differentiated thyroid cancer is performed on the second operation
GUAN Yun-zhu
Objective To explore the influence of whether or not the first operation is standard for differentiated thyroid cancer on the second operation.Methods A retrospective analysis of the clinical data of 200 patients with differentiated thyroid cancer admitted to Ningde Hospital of Fujian Province from January 2019 to January 2020 was made.All patients received reoperation.According to the standard of the first operation,they were divided into two groups.The control group (n=100) was the non-standard operation group,and the observation group (n=100) was the standard operation group.Statistical analysis was performed on the patient′s disease recurrence,operation time,drainage time,invasion of surrounding tissues and incidence of complications.Results The recurrence rate of the observation group was lower than that of the control group,and the difference was statistically significant (P<0.05).The operation time and drainage time of the observation group were shorter than those of the control group,and the differences were statistically significant (P<0.05).There was no statistically significant difference in the violation of surrounding tissues between the two groups (P＞0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant (P＞0.05).Conclusion If the first operation for differentiated thyroid cancer is not standardized,it will increase the patient′s disease recurrence rate and increase the patient′s risk of reoperation.In order to improve the surgical treatment effect,it is necessary to standardize the first operation method and ensure the quality of surgical treatment.
2021 Vol. 28 (4): 102-104转111 [Abstract] ( 48 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
105 Clinical effect of cement injection of posterior convex formed bone in treating compression fractures of osteoporosis vertebral body in different parts
HU Guan-yong； XU Xin-ming ；CHENG Zhen-quan
Objective To analyze the clinical effect of vertebral kyphoplasty bone cement injection in the treatment of osteoporotic vertebral compression fractures at different sites.Methods Retrospectively analyzed the clinical data of 90 patients with osteoporotic vertebral compression fracture admitted to Leping Hospital of Traditional Chinese Medicine from January 2018 to February 2020.According to different fracture sites,the patients were divided into upper and middle thoracic segment (30 cases),thoracolumbar segment (30 cases) and lower thoracic segment (30 cases).all three groups were treated with kyphoplasty bone cement injection.Oswestry disability index (ODI),visual analogue scale(VAS) score,Cobb Angle and perioperative indicators were compared among the three groups.Results There was no statistically significant difference in ODI,Cobb Angle and VAS scores among the three groups before treatment (P>0.05).After treatment,Cobb Angle in the three groups were lower than those before treatment,VAS score and ODI were lower than those before treatment,and the differences were statistically significant (P<0.05).There was no statistically significant difference between the three groups in operation time,amount of bone cement injection and number of intraoperative transmission (P>0.05).Conclusion The clinical effect of vertebral kyphoplasty bone cement injection in the treatment of osteoporotic vertebral compression fractures in different parts is significant,so it is worthy to be widely used in clinic.

 
2021 Vol. 28 (4): 105-107 [Abstract] ( 47 ) HTML (30 KB)  PDF  (0 KB)  ( 8 )
108 Observation of the effect of manual reduction and surgical reduction on distal radius fracture
SUN Yue-xian；WANG Jiu-mei；ZHAO Li-li；GUO Chang-xiu；YU Jing

Objective To investigate the effects of manual reduction and surgical reduction on patients with distal radius fracture.Methods A total of 84 patients with distal radius fracture admitted to Mudanjiang Forestry Central Hospital from October 2018 to September 2019 were selected as the research objects.According to the random number table method,the patients were divided into manual reduction group (42 cases) and surgical reduction group (42 cases).Patients in the manipulative reduction group received manipulative reduction therapy,while patients in the surgical reduction group received surgical reduction therapy.Operation time,operation cost,fracture healing time,the total incidence of complications rate,wrist range of motion and pain were compared between the two groups.Results After treatment,wrist range of motion score of two groups was higher than that before treatment,and pain score was lower than that before treatment,the differences were statistically significant (P<0.05).The operative time of the surgical reduction group was longer than that of the manual reduction group,the operation cost was higher than that of the manual reduction group,and the fracture healing time was shorter than that of the manual reduction group,the total incidence of complications rate was lower than that of the manual reduction group,the wrist range of motion score was higher than that of the manual reduction group,and the pain score was lower than that of the manual reduction group,the differences were statistically significant (P<0.05).Conclusion In patients with distal radius fractures,surgical reduction is more effective and pain scores are lower.
2021 Vol. 28 (4): 108-111 [Abstract] ( 61 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
112 Effect of proximal femoral antirotation intramedullary nail internal fixation on hip function and quality of life in elderly patients with intertrochanteric fractures
SONG Qi-he； ZHANG Xiao-zhou；QIU Bo
Objective To investigate the effect of proximal femoral nail antirotation on hip function and quality of life in elderly patients with intertrochanteric fracture.Methods A total of 80 elderly patients with intertrochanteric fracture treated in Xiaogan Hospital Affiliated to Wuhan University of Science and Technology from December 2015 to December 2019 were selected as the research objects.According to the random number table method,the patients were divided into the control group (40 cases) and the experimental group (40 cases).The control group was treated with dynamic hip screw internal fixation,while the experimental group was treated with proximal femoral antirotation intramedullary nail internal fixation.Surgical indicators,hip function and quality of life were compared between the two groups.Results The operation time,surgical incision and fracture healing time in the experimental group were shorter than those in the control group,and the intraoperative blood loss was less than that in the control group,and the differences were statistically significant (P<0.05).The excellent and good rate of hip joint function in the experimental group (92.50%) was higher than that in the control group (75.00%),and the difference was statistically significant (P<0.05).The score of quality of life in the experimental group after treatment ([90.47±8.54]points) was higher than that in the control group([75.45±7.22]points),and the difference was statistically significant (P<0.05).Conclusion For the elderly patients with intertrochanteric fracture,the effect of proximal femoral nail antirotation is significant.
2021 Vol. 28 (4): 112-114 [Abstract] ( 59 ) HTML (29 KB)  PDF  (0 KB)  ( 9 )
115 Value of acupuncture combined with Zheng Shuhuo Tincture in treating sensory abnormality after endoscopic lumbar discectomy
FENG Chao
Objective To explore the clinical effect of acupuncture combined with Zheng Shuhuo Tincture in the treatment of sensory abnormality after lumbar discectomy under foramen endoscope.Methods A total of 80 patients with lumbar disc herniation who had postoperative sensory dysfunction after intervertebral foramen endoscopy admitted to Shandong Qingdao Hospital of Integrated Traditional and Western Medicine from May 2018 to November 2019 were selected as study subjects.According to the random number table method,the patients were divided into the control group and the observation group,with 40 cases in each group.The control group received conventional acupuncture,and the observation group combined Zheng Shuhuo Tincture locally on the basis of the control group.The overall sensory score of feet,two-point discrimination between plantar and dorsum after treatment,the conduction velocity of median nerve and peroneal nerve and the incidence of complications after followed up for 6 months were compared between the two groups.Results After treatment,the overall sensory score of the foot in both groups was higher than that before treatment,and the overall sensory score of the foot in the observation group was higher than that in the control group,the distance between the two points of the sole and dorsum of the foot in the observation group was shorter than that in the control group,the differences were statistically significant (P<0.05).During the follow-up period,the conduction velocity of median nerve and peroneal nerve in the observation group were faster than those in the control group,the differences were statistically significant(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant (P<0.05).Conclusion Acupuncture combined with local application of Zheng Shuhuo Tincture can effectively improve the sensory function of lower limbs,promote the recovery of sensory discrimination and reduce postoperative complications for patients with abnormal sensation after lumbar discectomy under foramen endoscope.
2021 Vol. 28 (4): 115-118 [Abstract] ( 47 ) HTML (35 KB)  PDF  (0 KB)  ( 6 )
119 Expression and significance of S100A8/A9 and S100A4 in vulvar sclerosing mosses
CHEN Xiao-dan； MENG Fei；WU Xin
Objective To detect the expression of S100A8/A9 and S100A4 in vulvar sclerosing mosses,and to explore the relationships between S100A8/A9,S100A4 and vulvar sclerosing mosses.Methods Thirty surgical specimens were collected from the Department of Gynecology of the First Affiliated Hospital of China Medical University from January 2008 to January 2018 in patients with vulvar sclerosing mosses.The normal vulva skin samples of 10 patients who needed vaginal surgery such as uterine prolapse from January 2013 to January 2018 were selected from the Gynecological Ward of the First Affiliated Hospital of China Medical University.The samples were detected by SABC immunohistochemistry.The expression of S100A8/A9 and S100A4 were analyzed.Results In normal skin of vulva,S100A8/A9 positive cells were mostly located in basal cell layer,and the optical density of S100A8/A9 positive cells was 0.7946±0.1369.However,in vulvar sclerosing mosses,S100A8/A9 positive cells were mostly located near the whole layer of epidermis,and the optical density of S100A8/A9 positive cells was 1.6206±0.4312.The optical density of S100A8/A9 positive cells in vulvar sclerosing mosses was higher than that in normal vulva skin,and the difference was statistically significant (P<0.05).In normal skin of vulva,S100A4 positive cells were mostly located in basal cell layer,and a small amount of stromal cells were positively expressed in dermis.The optical density of S100A4 positive cells was 0.3020±0.1266.However,in mosses sclerosing vulva,S100A4 positive cells were still located in the basal layer and were negatively expressed in the interstitium.The optical density of S100A4 positive cells was 0.3583±0.1575.There was no significant difference in the optical density of S100A4 positive cells between mosses sclerosing vulva and normal vulva skin samples (P>0.05).Conclusion S100A8/A9 take a part in the pathological process of vulvar sclerosing mosses,however S100A4 may not have definite correlation with the pathological process of vulvar sclerosing mosses.
2021 Vol. 28 (4): 119-121转125 [Abstract] ( 59 ) HTML (33 KB)  PDF  (0 KB)  ( 9 )
122 Effect of different vitamin D levels on the treatment outcome of children with allergic purpura
YANG Pei； CAO Ning-li ；HU Hua-dong
Objective To explore the effect of different vitamin D levels on the treatment outcome of children with allergic purpura.Methods A total of 100 cases of children diagnosed as allergic purpura admitted to the Department of Pediatrics in Maternal and Child Health Hospital of Jiujiang City for the first time from January 2017 to June 2019 were selected.All the children were tested for 25 hydroxyvitamin D levels before treatment.According to the levels of 25 hydroxyvitamin D before treatment,they were divided into control group (25 hydroxyvitamin D≤20 ng/mL,vitamin D level was insufficient,50 cases) and observation group (25 hydroxyvitamin D>20 ng/mL,vitamin D level was normal,50 cases).Both groups received Vitamin D Capsules in addition to conventional treatment and were followed up.The clinical efficacy,recurrence during the follow-up and kidney damage after the follow-up were compared between the two groups.Results The clinical efficacy of the observation group was better than that of the control group,the difference was statistically significant (P<0.05).The total effective rate of observation group was higher than control group,and the difference was statistically significant (P<0.05).There were no significant differences in 24 h urinary trace albumin and urea nitrogen levels before treatment between the two groups (P>0.05).The 24 h urinary trace albumin and urea nitrogen levels at the end of follow-up after treatment in both groups were lower than those before treatment,and 24 h urinary trace albumin and urea nitrogen levels in the observation group were lower than those in the control group,with statistically significant differences (P<0.05).The recurrence rate in the observation group was lower than that in the control group during the follow-up,and the difference was statistically significant(P<0.05).Conclusion Compared with those with insufficient vitamin D levels,children with allergic purpura with normal vitamin D levels before treatment can obtain better clinical treatment effect after treatment,lower 24 h urinary trace albumin and urea nitrogen levels,longterm renal damage and disease recurrence rates are also lower.It can obtain better clinical therapeutic effect.
2021 Vol. 28 (4): 122-125 [Abstract] ( 59 ) HTML (32 KB)  PDF  (0 KB)  ( 9 )
126 Discussion on the usage time of COOK cervical balloon dilator to promote cervical maturation
LI Fei-zhen
Objective To explore the usage time of COOK cervical balloon dilator to promote cervical maturation.Methods A total of 105 pregnant and full-term women who had induced labor in Jingdezhen First Hospital from February 2018 to December 2019 were selected as the study objects.According to the random number table method，the selected patients were divided into the observation group (52 cases) and the control group (53 cases).In the control group,COOK cervical balloon was placed at 8∶00 p.m.of the day before induction of labor,and which was taken out at 8∶00 a.m.of the next day,it was placed for 12 h.In the observation group,COOK cervical balloon was placed at 10∶00 p.m.of the day before induction of labor,and which was taken out at 6∶00 a.m.of the next day,it was placed for 8 h.The cervical score,fetal heart rate monitoring score and pregnant women′s body temperature before balloon placement and after removing balloon were recorded,and the first stage,second stage and third stage of labor were compared between the two groups.Results The differences were not statistically significant in cervical score and fetal heart rate monitoring score between the two groups before balloon placement (P>0.05).The cervical score and fetal heart rate monitoring score of the two groups after removing balloon were higher than those before balloon placement,with significant statistics differences (P<0.05).The differences were not statistically significant in cervical score and fetal heart rate monitoring score between the observation group and the control group after removing balloon (P>0.05).The difference was not statistically significant in body temperature between the two groups before balloon placement (P>0.05).The differences were not statistically significant in body temperatures of the two groups between before balloon placement and after removing balloon (P>0.05).The difference was not statistically significant in body temperature between the two groups after removing balloon (P>0.05).There were no significant differences between the observation group and the control group in the first,second and third stages of labor (P>0.05).There were no significant differences in the levels of C-reactive protein,procalcitonin and leukocyte count between the two groups before balloon placement (P>0.05).The levels of C-reactive protein,procalcitonin and leukocyte count in the control group after removing balloon were higher than those before balloon placement,with significant statistics differences (P<0.05).The levels of C-reactive protein,procalcitonin and leukocyte count of the observation group after removing balloon were lower than those of the control group,with significant statistics differences (P<0.05).There were no significant differences in the levels of C-reactive protein,procalcitonin and leukocyte count of the observation group after removing balloon and before balloon placement (P>0.05).Conclusion The effect of COOK cervical balloon dilator to promote cervical maturation is significant,which can significantly improve cervical score and fetal heart rate monitoring score,and the effect of 8 hours of placement is equivalent to 12 hours,so 8 hours placement is the first choice clinically.However,12 hours placement can improve the levels of C-reactive protein,procalcitonin and leukocyte count.Therefore,the clinician can choose the placement time according to the condition of the pregnant woman.
2021 Vol. 28 (4): 126-129 [Abstract] ( 61 ) HTML (38 KB)  PDF  (0 KB)  ( 9 )
130 Effect of Loratadine combined with Methylprednisolone in the treatment of children with henoch chonlein purpura
ZHU Cheng； LUO Xin-fu
]Objective To investigate the effect of Loratadine combined with Methylprednisolone in the treatment of children with henoch schonlein purpura.Methods A total of 50 children with henoch schonlein purpura treated in General Hospital of Pingxiang Mining Group Co.,Ltd.,Jiangxi Province from March 2018 to February 2020 were selected and divided into control group (25 cases) and observation group (25 cases) according to random number table method.The control group was treated with Loratadine,and the observation group was treated with Methylprednisolone.The efficacy,serum levels of inflammatory factors,improvement time of clinical symptoms and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant (P<0.05).C-reactive protein and IgA in observation group were lower than those before intervention and those in control group,the differences were statistically significant (P<0.05).The levels of complement C3 and C4 in the observation group were lower than those before intervention and in the control group,the differences were statistically significant (P<0.05).The improvement time of clinical symptoms in the observation group was shorter than that in the control group,the differences were statistically significant (P<0.05).No obvious adverse reactions occurred in both groups.Conclusion For children with henoch schonlein purpura,Loratadine combined with Methylprednisolone pulse therapy can improve the clinical efficacy of children,shorten the improvement time of clinical symptoms,improve the level of serum inflammatory factors,and does not increase adverse reactions,which has high application value.
2021 Vol. 28 (4): 130-132转136 [Abstract] ( 58 ) HTML (30 KB)  PDF  (0 KB)  ( 9 )
133 Effect of low-dose Aspirin combined with artificial insemination of husband in uterine cavity on endometrial receptivity and pregnancy rate in patients with unexplained infertility
WANG Jia-yuan； MA Yao1 WANG Jin
Objective To explore the effect of low-dose Aspirin combined with artificial insemination of husband in uterine cavity on endometrial receptivity and pregnancy rate in patients with unexplained infertility.Methods A total of 88 patients with unexplained infertility treated in Dalian Maternal and Child Health Hospital from June 2019 to July 2020 were selected as the research subjects,random number table method was used to divide them into control group and observation group,44 cases in each group.The control group was used artificial insemination of husband in uterine cavity,and the observation group was used low-dose Aspirin combined with artificial insemination of husband in uterine cavity.The endometrial receptivity and pregnancy rate were compared between the two groups.Results There were no significant differences in endometrial thickness (Em),pulse index (PI) and resistance index (RI) between the two groups before treatment (P>0.05).After 4 weeks of treatment,Em levels in both groups were higher than those before treatment,while PI and RI in both groups were lower than those before treatment,with statistically significant differences (P<0.05).After 4 weeks of treatment,Em in the observation group was higher than that in the control group,while PI and RI in the observation group were lower than those in the control group,with statistically significant differences (P<0.05).There was no significant difference in pregnancy rate between the two groups after 2 weeks of treatment(P>0.05).There were no significant difference in pregnancy rates between the two groups after 4 weeks of treatment and 2 weeks of treatment (P>0.05).After 4 weeks of treatment,the pregnancy rate in the observation group was higher than that in the control group,and the difference was statistically significant (P<0.05).Conclusion Low-dose Aspirin combined with artificial insemination of husband in uterine cavity can effectively improve endometrial receptivity of patients with unexplained infertility and increase pregnancy rate,with higher application value.
2021 Vol. 28 (4): 133-136 [Abstract] ( 51 ) HTML (33 KB)  PDF  (0 KB)  ( 9 )
137 Clinical effect of prefilled Hydroxyethyl starch combined with Phenylephrine infusion to prevent supine syndrome during cesarean section
HU Ming-xiu；YU Wang-jun； ZHOU Liu-yu；WU Gang； CHEN Ru-kang
Objective To explore the clinical effect of prefilled Hydroxyethyl starch combined with Phenylephrine infusion to prevent the occurrence of supine syndrome during cesarean section.Methods A total of 108 women accepting cesarean section admitted to Dongguan Shuixiang Central Hospital from April 2019 to April 2020 were selected.According to the random number table method,they were divided into three groups,A,B and C,with 36 cases in each group.In group A,compound sodium chloride injection in intravenous drip was used 30 min before anesthesia.In group B and C,intravenous drip of Hydroxyethyl starch 30 min before anesthesia was applied,and in group C,Phenylephrine was immediately added after successful anesthesia.The changes of systolic blood pressure (SBP),diastolic blood pressure (DBP) and heart rate (HR) of the three groups before anesthesia (T1),1 min after anesthesia (T2),3 min after anesthesia (T3),5 min after anesthesia (T4) and 10 min after anesthesia (T5),1 min and 5 min Apgar score of newborns,and incidence of supine syndrome during anesthesia were compared.Results There were no significant differences in SBP,DBP and HR indicators among the three groups at T1 (P>0.05).Compared with T1,the SBP of group A decreased at T3,T4,and T5,the SBP of group B decreased at T3 and T4,the SBP of group C increased at T3,the differences were statistically significant (P<0.05).Compared with T1,the DBP of group A decreased at T2,T3,and T4,the DBP of group B at T3,T4,and T5 decreased,the DBP of group C increased at T3,the differences were statistically significant (P<0.05).Compared with T1,the HR of group A increased at T2,T3,T4,and T5,the HR of group B increased at T3,T4,T5,the differences were statistically significant (P<0.05).Compared with T1,HR of group C was more stable at T2,T3,T4,T5,and the difference was not statistically significant (P>0.05).Compared with group A,the SBP of group B was higher at T4,in group C was higher at T3,T4,T5.The DBP in group B was higher at T4 and T5,and in group C was higher at T2,T3,T4,and T5.The HR in group B at T3 and T4 was lower and in group C,HR was lower at T2,T3,T4,and T5,the differences were statistically significant (P<0.05).Compared with group B,the SBP of group C increased at T2,T3,T4,and T5 and the DBP of group C was higher at T2,T3,and T4,and the HR of group C was lower at T2,T3,and T4,the differences were statistically significant (P<0.05).The 1 min Apgar score of newborns in group C was higher than that of group A and B,and the differences were statistically significant (P<0.05).5 min Apgar score was higher than that of 1 min in all three groups,and the differences were statistically significant (P<0.05).There was no statistical difference in 5 min Apgar score of the three groups (P>0.05).There was no significant difference in Apgar score between group A and B at 1 min and 5 min (P>0.05).The incidence of supine syndrome in the group C was lower than that of the A and B group,the differences were statistically significant (P<0.05).Conclusion The prefilled Hydroxyethyl starch combined with Phenylephrine infusion for cesarean parturient women has a remarkable effect on preventing the occurrence of supine syndrome,which can effectively improve the blood pressure and reduce the incidence of supine syndrome,and incrase the Apgar score of newborns.It can protect the safety of mother and child and is worthy of clinical promotion.
2021 Vol. 28 (4): 137-140 [Abstract] ( 52 ) HTML (48 KB)  PDF  (0 KB)  ( 8 )
141 Effect of restricted and open infusion on postoperative complications of abdominal surgery in elderly patients
CHEN Jing;WU Sui-ping;CAI Yi-liang;CHEN Jia-chen;XIE Kui-shan
Objective To explore the effect of restricted transfusion and open transfusion on postoperative complications of abdominal surgery in elderly patients.Methods The clinical data of 70 elderly patients with abdominal operation in Yangdong District People′s Hospital from April 2019 to April 2020 were retrospectively analyzed.According to the infusion method,they were divided into the restricted infusion group (35 cases) and the open infusion group (35 cases).Operative related indexes and postoperative complications were compared between the two groups.Results There was no significant difference in anesthesia time,operation time and intraoperative blood loss between the two groups (P＞0.05).The total transfusion volume and urine volume of patients in the restricted infusion group were less than those in the open infusion group,the differences were statistically significant (P<0.05).The total incidence of postoperative complications in the restricted infusion group was lower than that in the open infusion group,the difference was statistically significant (P<0.05).Conclusion Compared with open transfusion,restricted transfusion can effectively reduce the postoperative complications of abdominal surgery in elderly patients,so is worthy of promotion and application in the clinical.
2021 Vol. 28 (4): 141-143 [Abstract] ( 45 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
144 Evaluation and management of DVT risk during the perioperative period of BPH by combining color Doppler ultrasound of lower limbs with modified Caprini score
XU Da-jin； SHEN Si-yao； LI Zhi-qiang ；ZHAO Hong ；ZENG Xiao-chun ；CHEN Ting-ting
Objective To explore the risk assessment and management of deep vein thrombosis (DVT) of lower limbs risk during the perioperative period of benign prostatic hyperplasia (BPH) combined with modified Caprini score,and to provide reference for the formulation of clinical intervention programs.Methods A total of 80 male patients with BPH admitted to Jiangxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine from January 2015 to December 2018 were selected as the research objects.The risk of DVT was evaluated by modified Caprini score before the operation and graded management was carried out.1 month after the operation,the occurrence of DVT was detected by lower limb vein color ultrasound.Results Among the 80 male patients with BPH,there were 42 patients in the lowrisk group,24 patients in the medium-risk group and 14 patients in the high-risk group.After 1 month of follow-up,10 cases occurred DVT by the examination of color Doppler ultrasound of lower limbs.The positive rate of DVT in the high-risk group was higher than that in the medium-risk group,and the modified Caprini score was higher than that in the low-risk group and the medium-risk group,the occurrence time of DVT was shorter than that in the intermediaterisk group,and the difference were statistically significant (P<0.05).The sensitivity and specificity of DVT were all 100% with the threshold value of moderate risk (3-4 points),and the evaluation effect was relatively good.Conclusion The use of modified Caprini score risk assessment model to screen for DVT in patients with BPH during the perioperative period can effectively predict the occurrence of DVT,and the modified Caprini score has a higher value with moderate risk (3-4 points) as the evaluation threshold.
2021 Vol. 28 (4): 144-146 [Abstract] ( 46 ) HTML (30 KB)  PDF  (0 KB)  ( 9 )
147 Clinical features of active bleeding in patients with hypertensive cerebral hemorrhage
XIONG Meng
Objective To investigate the early CT findings of patients with hypertensive intracerebral hemorrhage and the clinical characteristics of hematoma and active intracerebral hemorrhage.Methods A total of 60 patients with hypertensive cerebral hemorrhage who treated in First People′s Hospital of Ji′an City from June 2018 to June 2020 were selected as the research objects.According to weather they had active bleeding,they were divided into the experimental group (active bleeding) with 15 patients and the control group (without active bleeding) with 45 patients.All of the patients were received CT examinations.The proportion of basal ganglia hemorrhage,hematoma morphology and cerebral hemorrhage volume were compared between the two groups.Results The proportion of basal ganglia hemorrhage in experimental group was lower than that in control group,and the difference was statistically significant (P<0.05).In the experimental group,the bleeding sites in the basal ganglia were mainly in the internal capsule,while in the control group,the bleeding sites in the basal ganglia were mainly in the internal capsule and external capsule.The difference of hematoma morphology between the experimental group and the control group was statistically significant (P<0.05).The amount of cerebral hemorrhage in experimental group was more than that in control group,and the difference was statistically significant (P<0.05).Conclusion For patients with hypertensive intracerebral hemorrhage,CT examination should be performed in time.For patients with active bleeding,their hematoma will change accordingly,and the patients′ bleeding volume will appear to increase,which is not conducive to the prognosis of patients.
2021 Vol. 28 (4): 147-149 [Abstract] ( 45 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
150 Comparison of clinical value of bedside chest X-ray and lung ultrasound in the diagnosis of newborn pneumothorax
XU Bo；YANG Zi；ZHOU Hai-yan；LIN Xiao-ying；ZHU Cai-yi
Objective To compare the diagnostic value of bedside chest X-ray and lung ultrasound in newborn pneumothorax.Methods A total of 60 newborns with suspected pneumothorax admitted to Ultrasound Medicine Department of Shenzhen Bao′an District Maternal and Child Health Hospital Affiliated to Ji′nan University Medical College from March 2018 to March 2020 were selected as the research objects.Chest X-ray and lung ultrasound examination were performed beside the bed,and chest CT was adopted as the gold standard for the diagnosis of pneumothorax.The diagnostic effectiveness and timeliness of the two methods for newborn pneumothorax were compared.Results For the diagnosis of newborn pneumothorax,the sensitivity,specificity and accuracy of bedside chest X-ray diagnosis were 88.46%(46/52),87.50% (7/8) and 88.33% (53/60) respectively,and the sensitivity,specificity and accuracy of bedside lung ultrasound diagnosis were 96.15% (50/52),100% (8/8) and 96.67% (58/60) respectively,there were no statistically significant differences between the two methods in sensitivity,specificity and accuracy (P>0.05).The time of bedside lung ultrasound examination was shorter than that of bedside chest X-ray examination,and the difference was statistically significant (P<0.05).Conclusion The diagnosis of neonatal pneumothorax by bedside chest X-ray and lung ultrasound have higher diagnostic value,but the examination time of bedside lung ultrasound is shorter.
2021 Vol. 28 (4): 150-152 [Abstract] ( 50 ) HTML (29 KB)  PDF  (0 KB)  ( 7 )
153 Application value of MRI examination in diagnosis of postoperative local recurrence of rectal cancer
ZHU Feng
Objective To investigate the value of magnetic resonance imaging (MRI) in the diagnosis of postoperative local recurrence of rectal cancer.Methods A total of 79 patients with suspected postoperative local recurrence of rectal cancer who admitted to Anshan Central Hospital of Liaoning Province from June 2018 to June 2019 were selected as the research objects.All of the patients were diagnosed with MRI and computed tomography (CT) examinations.The pathological results of surgical biopsy were used as the gold diagnostic standard.The sensitivity,specificity and accuracy of MRI and CT examination in diagnosis of postoperative local recurrence of rectal cancer were compared.Results The pathological results of surgical biopsy showed that there were 48 patients with positive postoperative local recurrence of rectal cancer among the 79 patients with suspected postoperative local recurrence of rectal cancer,and 31 patients were benign changes.There were 49 patients of postoperative local recurrence of rectal cancer diagnosed by MRI examination,45 patients were true positive.There were 46 patients of postoperative local recurrence of rectal cancer diagnosed by CT examination,37 patients were true positive.The sensitivity,specificity and accuracy of MRI examination in the diagnosis of postoperative local recurrence of rectal cancer were 93.75%,87.10%,91.14%,which were higher than 77.08%,70.97%,74.68% of the CT examination,and the differences were statistically significant (P<0.05).Conclusion In the diagnosis of postoperative local recurrence after rectal cancer,the MRI examination has better sensitivity,specificity and accuracy,which can be used as an important means of clinical diagnosis.
2021 Vol. 28 (4): 153-155 [Abstract] ( 52 ) HTML (30 KB)  PDF  (0 KB)  ( 10 )
156 Application value of vascular ultrasound examination in diagnosis of carotid artery stenosis in patients with ischemic cerebrovascular disease
ZHANG Wei
Objective To explore the application value of vascular ultrasound examination in the diagnosis of carotid artery stenosis in patients with ischemic cerebrovascular disease.Methods A total of 71 patients with ischemic cerebrovascular disease who were admitted to Shenyang Second Hospital of Traditional Chinese Medicine from February 2017 to March 2019 were selected as the research objects.All of the patients underwent vascular ultrasound examination.Cerebrovascular angiography results were used as the gold standard.The application value of vascular ultrasound examination in the diagnosis of carotid artery stenosis in patients with ischemic cerebrovascular disease was analyzed.Results According to cerebral angiography results,15 patients were diagnosed with mild carotid stenosis,45 patients with moderate carotid stenosis,8 patients with severe carotid stenosis and 3 patients with complete occlusion among the 71 patients.The accuracy of vascular ultrasound examination in the diagnosis of carotid artery stenosis in patients with ischemic cerebrovascular disease was 88.73% (63/71).The consistency of diagnosis results of vascular ultrasound examination and cerebrovascular angiography in the diagnosis of carotid artery stenosis in patients with ischemic cerebrovascular disease was good based on the Kappa consistency check (Kappa=0.798,P=0.000).The receiver operating characteristic (ROC) curve showed that the area under curve (AUC) of vascular ultrasound examination in the diagnosis of carotid artery stenosis in patients with ischemic cerebrovascular disease was 0.956,indicating good diagnostic value.The sensitivity and specificity were 0.933 and 0.046.Conclusion The application value of vascular ultrasound examination in the diagnosis of carotid artery stenosis in patients with ischemic cerebrovascular disease is significant,and has good consistency with the diagnosis result of cerebral angiography.
2021 Vol. 28 (4): 156-159 [Abstract] ( 48 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
160 Department of Radiology,Shenyang Orthopaedic Hospital,Liaoning Province,Shenyang 110044,China
DONG Lei；GAO Hong▲

Objective To sketch out the clinical application of 3D printing technology based on MRI of Orthopedics and Traumatology Department by means of literature retrieval,in order to provide a scientific basis for promoting the development of precise medical treatment in Orthopedics and Traumatology Department.Methods The databases of China National Knowledge Internet(CNKI),Wanfang and VIP were retrieved from January 1,2015 to September 30,2019,and key words were "3D printing" "three-dimensional printing" "additive manufacturing" "magnetic resonance" "magnetic resonance imaging".A total of 18 literatures related to Orthopedics and Traumatology Department were included in the review.Results 3D printing technology based on MRI was mainly used in the diagnosis and treatment of clinical diseases and clinical teaching in Orthopedics and Traumatology Department.Conclusion 3D printing technology based on MRI can not only be used for surgical preoperative planning,assisted determination of operative plan,but also printing individualized guides,prostheses and implants to improve the effect of orthopaedics and traumatology surgery.
2021 Vol. 28 (4): 160-162 [Abstract] ( 57 ) HTML (31 KB)  PDF  (0 KB)  ( 9 )
163 Effect of color Doppler ultrasonography in the diagnosis of placenta previa and placenta implantation
LYU Zhi-ru；WANG Xiao-dan； LIU Wei
Objective To investigate the effect of color Doppler ultrasonography in the diagnosis of placenta previa and placenta implantation.Methods A total of 88 patients with highly suspected placenta praevia and placenta implantation who were treated in Dalian Maternal and Child Health Hospital from March 2017 to December 2019 were selected as the research objects.All the patients received conventional 2D ultrasound and color Doppler ultrasound.The surgical pathological results were taken as the "gold standard".The diagnostic effect of conventional 2D ultrasound and color Doppler ultrasound were analyzed.Results There were 79 patients with placenta previa and placenta implantation among the 88 suspected patients.The accuracy of color Doppler ultrasound diagnosis of placenta previa and placenta implantation was 94.32% (83/88),which was higher than the 76.14% (67/88) of conventional 2D ultrasound,and the difference was statistically significant (P<0.05).Receiver operating characteristic (ROC) curve analysis showed that the area under the (AUC) and sensitivity of color Doppler ultrasound diagnosis were higher than those of conventional 2D ultrasound diagnosis,and the differences were statistically significant (P<0.05).Conclusion Color Doppler ultrasound has high diagnostic effect in placenta praevia and placenta implantation,which provides an important reference for diagnostic of placental implantation,and has positive significance for treatment and prognosis.
2021 Vol. 28 (4): 163-165 [Abstract] ( 54 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
166 Analysis of the application of multi-drug compatibility and adverse reactions in Western medicine
WANG Li-juan
Objective To analyze the adverse reactions of multi-drug compatibility in Western medicine,so as to promote rational drug use in Western medicine.Methods A study was conducted on 1262 prescriptions of the Second People′s Hospital of Fuxin City from January to August 2018 to analyze the occurrence of adverse reactions caused by unreasonable multi-drug combination of Western medicine.Results Among the 1262 prescriptions of the Second People′s Hospital of Fuxin City,65 prescriptions (5.15%) of adverse reactions were caused by unreasonable combination of Western medicine.The main adverse reactions of the patients were digestive tract adverse reactions such as nausea and vomiting (38.46%),skin allergy and pruritus (27.69%),dizziness,weakness and insomnia (30.77%),heart,liver,kidney and other important organ failure (3.08%).Aspirin,Cephalosporin and Aminophylline for a higher proportion,of the 65 prescriptions of adverse reactions caused by unreasonable combination of Western medicine,all were 30.77%.Conclusion In the Second People′s Hospital of Fuxin City of Western medicine,there is still the phenomenon of adverse reactions caused by unreasonable drug compatibility.Therefore,attention must be paid to strengthen the correct compatibility of drugs in clinical practice to ensure the rationality of drug use and reduce adverse reactions.
2021 Vol. 28 (4): 166-168转172 [Abstract] ( 46 ) HTML (30 KB)  PDF  (0 KB)  ( 9 )
169 Clinical effect of Albumin-bound Paclitaxel combined with Tegafur Gimeracil Oteracil Potassium in the treatment of elderly advanced pancreatic cancer
PAN Ren-feng
Objective To investigate the clinical effect of Albumin-bound Paclitaxel combined with Tegafur Gimeracil Oteracil Potassium in the treatment of elderly advanced pancreatic cancer.Methods A total of 50 elderly patients with advanced pancreatic cancer admitted to the Fifth People′s Hospital of Dalian from January 2018 to January 2020 were selected as the research subjects.By the random number table method,they were divided into test group (n=25) and control group (n=25).Patients in the test group were treated with Albumin-bound Paclitaxel combined with Tegafur Gimeracil Oteracil Potassium,and in the control group,Gemcitabine was used.The clinical efficacy,overall survival,median survival and 6-month survival rate of the two groups were compared.The adverse reactions of the two groups were also compared.Results The disease control rate and 6-month survival rate of the test group were higher than those of the control group,the overall survival and median survival were longer than those of the control group,with statistically significant differences (P<0.05).There was no statistical difference in the effectiveness rate between the two groups (P>0.05).The incidence rates of adverse reactions such as leukopenia,thrombocytopenia and nausea and vomiting in the test group were lower than those in the control group,and the differences were statistically significant (P<0.05).Conclusion For elderly patients with advanced pancreatic cancer,the combination of Albumin-bound Paclitaxel and Tegafur Gimeracil Oteracil Potassium has good efficacy and safety for them.
2021 Vol. 28 (4): 169-172 [Abstract] ( 60 ) HTML (36 KB)  PDF  (0 KB)  ( 6 )
173 Clinical effect of traditional Chinese medicine foot bath combined with Hongjin Xiaojie Capsules on the treatment of primary dysmenorrhea with qi stagnation and blood stasis
ZHENG Ying-hui
Objective To investigate the clinical effect of traditional Chinese medicine (TCM) foot bath combined with Hongjin Xiaojie Capsules on the treatment of primary dysmenorrhea with qi stagnation and blood stasis.Methods A total of 60 patients with primary dysmenorrhea of qi stagnation and blood stasis who treated in Guangzhou Hospital of Integrated Traditional and Western Medicine from June 2018 to December 2019 were selected as the research objects and divided into the control group and the observation group according to random number table method,with 30 cases in each group.The control group was given Hongjin Xiaojie Capsules.The observation group was given TCM foot bath on the basis of the control group.After 3 menstrual cycles of treatment,the TCM syndrome score,therapeutic effect and hemorheology indexes of the two groups were compared.Results After treatment,the TCM syndrome scores,whole blood viscosity high shear 200/s,whole blood viscosity low shear 1/s,plasma viscosity and erythrocyte aggregation index of the two groups were lower than those before treatment,the erythrocyte electrophoresis time was shorter than that before treatment,and the differences were statistically significant (P<0.05).After treatment,the TCM syndrome scores,whole blood viscosity high shear 200/s,whole blood viscosity low shear 1/s,plasma viscosity and erythrocyte aggregation index of the observation group were lower than those of the control group,the erythrocyte electrophoresis time was shorter than that of the control group,and the differences were statistically significant (P<0.05).The total effective rate of the observation group (90.00%) was higher than that of the control group (56.67%),and the difference was statistically significant (P<0.05).Conclusion TCM foot bath combined with Hongjin Xiaojie Capsules on the treatment of primary dysmenorrhea with qi stagnation and blood stasis can improve the TCM syndrome and hemorheology indexes of patients,and has good curative effect.
2021 Vol. 28 (4): 173-176 [Abstract] ( 58 ) HTML (36 KB)  PDF  (0 KB)  ( 10 )
177 Clinical effect of formula with warming yang to promote defecation combined with Chinese herbal medicines for warm compress in the treatment of functional constipation in the elderly
LI Hui-yi;ZHAO Li-shuang; WANG Ze;ZHOU Hai-feng
Objective To explore the clinical effect of formula with warming yang to promote defecation combined with Chinese herbal medicines for warm compress in the treatment of functional constipation in the elderly.Methods A total of 128 elderly patients with functional constipation admitted to Dehui Traditional Chinese Medicine Hospital from June 2018 to June 2019 were selected as subjects.They were divided into observation group and control group by the random number table method,with 64 cases in each group.In the control group,conventional treatment in Western medicine was used,while in the observation group,formula with warming yang to promote defecation combined with Chinese herbal medicines for warm compress was adopted.After one month of treatment,the efficacy of the two groups was observed and compared,the severity of constipation and the change in quality of life were analyzed,and the recurrence rates of the two groups were calculated.Results The total clinical effective rate of the observation group (95.31%)was higher than that of the control group (89.06%),the difference was statistically significant (P<0.05).After 1 month of treatment,the severity of constipation (CCS) score of the observation group was (40.34±4.29) points,lower than that of the control group of (58.01±4.11) points,and the difference was statistically significant (P<0.05).The recurrence rate of 6 months after treatment in the observation group (4.69%) was lower than that in the control group (23.43%),with statistically significant difference (P<0.05).After 1 month of treatment and 6 months after treatment,the quality of life scale for patients with constipation (PAC-QOL) scores in the observation group were lower than those in the control group,with statistically significant differences (P<0.05).Conclusion Formula with warming yang to promote defecation combined with Chinese herbal medicines for warm compress in the treatment of functional constipation in the elderly has a remarkable curative effect at advantages of alleviating constipation,reducing the recurrence rate and improving the quality of life.It is worthy of clinical attention,promotion and application.
2021 Vol. 28 (4): 177-180 [Abstract] ( 47 ) HTML (39 KB)  PDF  (0 KB)  ( 8 )
181 Consideration of traditional Chinese medicine differentiation and treatment of novel coronavirus pneumonia from Treatise on Epidemic Febrile Disease
JIANG He; ZHANG Hong-li ;YU Hong-xue ;SU Huan-huan
The novel coronavirus pneumonia (COVID-19) was out broke in Wuhan in December 2019.Traditional Chinese medicine (TCM) was effective in the treatment of COVID-19,and TCM had been combating epidemic diseases since ancient times.Therefore,TCM had rich experience in preventing and treating epidemic disease.The COVID-19 was also belonged to the category of "plague" in TCM,it was found that early clinical symptoms of the patients were febrile or no fever,most of the febrile patients with hiding fever were accompanied by vomiting,stupor,diarrhea,loose stool and other damp toxin trapped in the spleen."Dampness-Toxin" was the core pathogen which had been recognized,and the disease mainly involved the lung and the spleen,it was with wei-qi-ying-blood transmission law and perverse pericardium was often severe,hyperactivity of epidemic qi and decline of healthy qi caused inconstancy.The author considered the differentiation and treatment of COVID-19 from Treatise on Epidemic Febrile Disease written by master Ye Tian-shi with the outline of wei-qi-ying-blood.
2021 Vol. 28 (4): 181-184 [Abstract] ( 58 ) HTML (38 KB)  PDF  (0 KB)  ( 9 )
185 Effect of Wenyang Lishui Decoction combined with Furosemide in the treatment of chronic heart failure
WANG Lei ;LI Yi
Objective To explore the clinical effect of Wenyang Lishui Decoction combined with Furosemide in the treatment of chronic heart failure.Methods A total of 70 patients with chronic heart failure admitted to Pingxiang Hospital of Traditional Chinese Medicine from August 2019 to March 2020 were selected as the research objects and divided into the control group and the observation group according to the random drawing method,with 35 cases in each group.The control group was treated with Furosemide,and the observation group was treated with Wenyang Lishui Decoction combined with Furosemide.The efficacy,cardiac function,total effective rate,left ventricular ejection fraction (LVEF) and plasma brain natriuretic peptide (BNP) level and other related indicators were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant (P<0.05).Before treatment,the LVEF and BNP levels of the observation group were not statistically significant compared with the control group (P>0.05).After treatment,the LVEF level of the observation group was higher than that of the control group,and the BNP level was lower than that of the control group,the differences were statistically significant (P<0.05).Conclusion Wenyang Lishui Decoction combined with Furosemide can improve the heart function of patients with chronic heart failure,and the clinical effect is remarkable.
2021 Vol. 28 (4): 185-187 [Abstract] ( 54 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
188 Clinical Effect of Banxia Xiexin Decoction in the auxiliary treatment of peptic ulcer with disharmony of liver and spleen
LIU Yun-yang ;YU Ying ;YANG Shi
Objective To explore the clinical effects of application of Banxia Xiexin Decoction combined with Omeprazole in the treatment of peptic ulcer (PU) with disharmony of liver and spleen.Methods A total of 74 cases of PU patients with liver and spleen discordant type who were treated in Outpatients Department of Traditional Internal Medicine of Dongguan Qishi Hospital from January 2018 to November 2019 were selected as the research objects and divided into the control group and the study group according to the coin flip method,with 37 cases in each group.The control group was treated with Omeprazole,and the study group was treated with Banxia Xiexin Decoction on the basis of the control group.The total clinical effective rate,symptom score,inflammatory factor level and adverse reactions of the two groups were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant (P<0.05).The syndrome integrals of gastric cavity pain,belching,acid reflux and interleukin-6 (IL-6),interleukin-8 (IL-8),tumor necrosis factor-α (TNF-α) levels were lower than those of control group,and the differences were statistically significant (P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion Application of Banxia Xiexin Decoction combined with Omeprazole has clinical effect in the treatment of PU with disharmony of liver and spleen,which can improve the patients′ clinical symptoms and inflammations.
2021 Vol. 28 (4): 188-191 [Abstract] ( 52 ) HTML (35 KB)  PDF  (0 KB)  ( 9 )
192 Effects of Tongqiao Huoxue Decoction combined with Galantamine on brainstem evoked potentials and cognitive function in patients with Alzheimer′s disease
JIANG Yong-qiu;CAI Chao-qun
Objective To explore the effect of Tongqiao Huoxue Decoction combined with Galantamine on brainstem evoked potentials and cognitive function in patients with Alzheimer′s disease (AD).Methods A total of 90 patients with AD who were treated in Yueyang Hospital of Chinese Medicine from September 2017 to June 2019 were selected as the research objects and divided into the control group and the observation group according to random number table method,with 45 cases in each group.The control group was treated with Galantamine,and the observation group was treated with Tongqiao Huoxue Decoction combined with Galantamine.Both groups were treated for 4 months.The curative effect,brainstem evoked potential and Mini-Mental State Examination (MMSE) score were compared between the two groups.Results After 4 months of treatment,the total effective rate,wave Ⅲ,wave Ⅴ,and MMSE scores of the observation group were higher than those of the control group,and the latency wave Ⅲand wave Ⅴwere lower than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion Tongqiao Huoxue Decoction combined with Galantamine can improve the cognitive function of AD patients,shorten the latency of brainstem evoked potentials and increase the amplitude of brainstem evoked potentials in AD patients.
2021 Vol. 28 (4): 192-195 [Abstract] ( 59 ) HTML (33 KB)  PDF  (0 KB)  ( 8 )
196 Study on the relation of social support between job satisfaction and work attitude in the clinical nurses of surgery department
LI Ai-xiang; LI Jing
Objective To explore the relation of social support between job satisfaction and work attitude in the clinical nurses of surgery department，in order to provide basis for nursing management.Methods The method of questionnaire was used,298 clinical surgical nurses were chosen from three general hospitals of Jining city from March to April 2020,they were researched by McCloskey/Mueller satisfaction scale (MMSS),social support rating scale (SSRS) and Utrecht work engagement scale (UWES),the relation of among job involvement,social support and job satisfaction was analyzed by Pearson correlation analysis,the mediation effect of social support between job satisfaction and work attitude was evaluated by regression analysis,Bootstrap procedure was applied to test the significance of the mediation effect of social support between job satisfaction and work attitude.Results The scores of SSRS,MMSS,UWES in 298 clinical surgical nurses were respectively (41.98±3.15) points,(3.71±0.61) points,(3.51±0.42) points.Correlation analysis showed that social support was positively correlated with job satisfaction and job involvement (P＜0.01).Mediation effect analysis showed mediation effect of social support between job satisfaction and work attitude was 0.136.Bootstrap test showed that 95%confidence interval of mediation effects of social support was 0.083 to 0.184.Conclusion Social support has a mediation effect between job satisfaction and work attitude in the clinical nurses of surgery department,it can mediate the relationship between job satisfaction and work attitude.
2021 Vol. 28 (4): 196-199 [Abstract] ( 46 ) HTML (36 KB)  PDF  (0 KB)  ( 9 )
200 Literature analysis of adverse drug reactions induced by Montelukast Sodium
ZHOU Liang ;ZHAO Jiang-yan ;DONG Mei-mei ;HUANG Wen-yue ;TANG Cun-yang
Objective To investigate the characteristics and regularity of adverse drug reactions (ADR) induced by Montelukast Sodium and provide reference for safe drug use in clinic.Methods The papers of CNKI,VIP and Wangfang were retrieved and analyzed for collecting ADR reports induced by Montelukast Sodium from January 2000 to December 2019.Results This study screened 29 articles with 32 cases of ADR.In the 32 cases of ADR,22 cases （68.75%）were male and 10 cases（31.25%） were female,the youngest patient was 12 months,the oldest patient was 86 years old,and mainly occurred 1 to 3 d after medication (34.38%).Patients mainly suffered from bronchial asthma,bronchitis.Systems/organs involved in ADR were the nervous and mental system,skin and its accessories,and urinary system.Conclusion The ADR monitoring should be strengthened for ensuring safe and rational use of Montelukast Sodium.
2021 Vol. 28 (4): 200-202 [Abstract] ( 57 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
203 Phased evaluation of the clinical application of antibiotics in one stomatological hospital from 2012 to 2019
YU Jiao-ling
]Objective To collect the data of antibiotics in Dalian Stomatological Hospital for eight consecutive years from 2012 to 2019,and to evaluate the effect of special remediation activities of antibiotics.Methods Application data of antibiotics in Dalian Stomatological Hospital information system from 2012 to 2019 were collected,the utilization rate of antibiotics,the intensity of antibiotic use,the usage of all kinds of antimicrobial agents,the proportion of antibiotics used in the prevention of typeⅠincision,microbial testing rate of inpatients receiving antimicrobial therapy before use of antibiotics,ranking ratio of consumption sum/frequency and other indexes were analyzed.Results Compared with 2012,the antimicrobial agents usage rate of outpatient,emergence and inpatient respectively decreased 9.44%,14.56%and 35.22% in 2019,antimicrobial agents use intensity of inpatient patients decreased 63.26 DDDs/(100 persons·day),the proportion of inpatients receiving intravenous infusion and the amount of antibiotics used per capita decreased by 41.68% and 46.84% respectively,the rate of microbiological examination increased year by year before receiving antibiotics,type Ⅰincision without prophylactic medication for five consecutive years.Nitroimidazoles,macrolides and the first generation cephalosporins ranked the top three drugs in the ratio of consumption sum/frequency of drugs.Conclusion The data of eight consecutive years show that the use of antibiotics in this hospital has become more reasonable,but still need to strengthen management,prevent rebound,and continue to consolidate and improve the level of rational drug.
2021 Vol. 28 (4): 203-207 [Abstract] ( 52 ) HTML (34 KB)  PDF  (0 KB)  ( 9 )
208 Effect of cognitive behavioral intervention on compliance in the whole course of rabies vaccination
HUANG Hong-nv1 YANG Ai-hong;WANG Jin-ying; QIU Yan;SHENG Wan-qing;ZHU Xiang-bao
Objective To explore the effect of cognitive behavioral intervention on the compliance in the whole course of rabies vaccination.Methods From January to October 2019,a total of 100 rabies patients who were vaccinated in the Vaccination Clinic of Legang Health Center of Leping City were selected as the study objects.By using the random number table method,they were divided into the group A (n=50,routine nursing intervention) and group B (n=50,cognitive behavior intervention).The compliance rate,vaccination knowledge awareness rate and satisfaction of the two groups were compared.Results The compliance rate of group B was higher than that of group A,the difference was statistically significant (P<0.05).The awareness rate of vaccination knowledge of group B was higher than that of group A,the difference was statistically significant (P<0.05).The satisfaction of group B was higher than that of group A,and there was significant difference between the two groups (P<0.05).Conclusion The implementation of cognitive behavioral intervention in the whole course of rabies vaccination can improve the compliance rate of patients,facilitate them to understand more vaccination knowledge and improve their satisfaction to vaccination work.
2021 Vol. 28 (4): 208-210 [Abstract] ( 47 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
211 Epidemiological analysis of epidemic outbreak of epidemic encephalitis B of Dawa District in Panjin City in 2018
YU Zhen-rong
Objective To analyze the epidemiological characteristics of epidemic outbreak of epidemic encephalitis B of Dawa District in Panjin City in 2018,so as to provide basis for formulating prevention and control strategies.Methods The epidemic surveillance information,epidemiological investigation data and follow-up data of the epidemic of epidemic encephalitis B in 2018 and the historical data of epidemic encephalitis B in Dawa District from 1971 to 2017 were collected.Mosquito density and species were monitored by trap lamp method in residential corridors,rural cottage courtyards and livestock shed.Results From September 10 to October 10,2018,there was an outbreak of epidemic encephalitis B in Dawa District of Panjin City,16 confirmed cases with a morbidity of 3.60/100 000 and a fatality rate of 25.00%.There were 8 males and 8 females,12(75.00%)were over 40 years old,and 8(50.00%)were peasants.Six towns were affected by the epidemic,of which Tianjia Street had a maximum of 6 cases (37.50%).The onset time was concentrated from late August to mid-September 2018,with 3 cases (18.75%) in August and 13 cases (81.25%) in September.The median visiting and diagnostic time were 0.5 and 8 days after onset,respectively.One case collected cerebrospinal fluid and 15 cases collected serum for detection of epidemic encephalitis B IgM antibody,the positive rate was 100.00%.Nine cases (56.25%) had no history of epidemic encephalitis B vaccination,and seven cases (43.75%) had unknown vaccination history.The lowest density of mosquitoes was the 0.5/(lamp·h),the highest was 22.5/(lamp·h),and the median was 3.8 /(lamp·h).There were 7 epidemic spots in urban area,and 18 epidemic spots in rural area.Among them,17 (94.44%) were detected with Culex tritaeniorhynchus,and 912 mosquitoes were trapped,of which 247 (27.08%)were Culex tritaeniorhynchus.Conclusion There has been no epidemic of epidemic encephalitis B in Dawa District for 17 consecutive years.This outbreak is characterized by an increase in adult patients.It is the key to prevent and control the epidemic of epidemic encephalitis B by vaccinating adults,detecting and replanting children of appropriate age,preventing mosquitoes and killing mosquitoes,monitoring the epidemic situation of animals,and strengthening the ability of early diagnosis and treatment of medical institutions.
2021 Vol. 28 (4): 211-214 [Abstract] ( 43 ) HTML (36 KB)  PDF  (0 KB)  ( 8 )
215 Epidemiological characteristics analysis of 1096 hospitalized hand-footmouth disease cases in Zibo area
WANG Yin-hong;WANG Guang-juan; ZHAO Feng-kai;LI Guo-dong
Objective To analyze the epidemiological characteristics of 1096 hospitalized hand-foot-mouth disease cases in Zibo area from 2016 to 2018,in order to provide scientific and effective supports for taking targeted preventive measures,reducing the incidence of hand-foot-mouth disease,improving the cure rate of hand-foot-mouth cases and saving medical costs.Methods The data of 1096 children with hand-foot-mouth disease admitted to Zibo Maternal and Child Health Hospital from January 2016 to December 2018 were collected for descriptive analysis.Pharyngeal swabs were collected from 152 cases to analyze enterovirus types.Results The 1096 children with hand-foot-mouth disease from 2016 to 2018 included 5 severe cases and no deaths.The male to female ratio was 1.68∶1,there were more males than females,mostly scattered living children (77.65%).The onset month was mainly concentrated from June to August and from September to November.The age of the children was concentrated in 5 years old and younger,and children under 2 years old accounted for a higher proportion of hospitalized children.Rural children accounted for a higher proportion than urban children.Of the 152 pharyngeal swabs collected,there were 69 Enterovirus 71 (EV71) cases detected with a positive rate of 45.39%,there were 53 cases of Coxsackie virus A group 16 (Cox A16) detected with the positive rate of 34.87%,other enteroviruses detected were 30 cases with 19.74% positive rate.Conclusion During the high incidence of hand-foot-mouth disease in Zibo area,it should be strengthened the prevention and control of EV71 and Cox A16.The key time range of preventing and control for children with hand-foot-mouth disease in Zibo area is summer and autumn.The key age group of children with hand-foot-mouth disease prevention and treatment is under 5 years old,and the best treatment group after the onset is children under 2 years old.For early intervention and prevention,it is necessary to strengthen the hand-foot-mouth disease health education for scattered children and parents in rural areas.
2021 Vol. 28 (4): 215-218 [Abstract] ( 45 ) HTML (34 KB)  PDF  (0 KB)  ( 8 )
219 Effect analysis of progressive early rehabilitation training and nursing on mechanical ventilation of patients with severe acute pancreatitis
ZHENG Chun-mei; LI Pan-shi;DU Li-hua
Objective To explore the clinical effect of progressive early rehabilitation training and nursing on patients with severe acute pancreatitis (SAP) mechanical ventilation.Methods A total of 80 patients who underwent mechanical ventilation in the ICU of Dongguan People′s Hospital from November 2018 to October 2019 were selected and divided into two groups according to the random number table method,40 cases in each group.The control group was given the conventional nursing,the observation group was given the progressive early rehabilitation training nursing based on that.The two groups were evaluated for one-time offline success rate,mechanical ventilation time,hospital stay,pain score,the medical research council to assess patient muscle strength.Grips were used to assess the patient′s upper limb grip,Barthel scoring standard to assess patients′ self-care ability.Results The observation group′s one-off offline success rate was higher than that in the control group,the pain score was lower than that in the control group,the differences were statistically significant (P<0.05),and the mechanical ventilation time and hospital stay were shorter than those of the control group (P<0.05);the observation group′s muscle strength and grip strength scores were higher than those of the control group,the Barthel score of the observation group was higher than that of the control group,the differences were statistically significant (P<0.05).Conclusion The use of progressive early rehabilitation training for patients with SAP mechanical ventilation can not only shorten mechanical ventilation and hospital stay,but also effectively improve the quality of life of patients,which has certain clinical value.
2021 Vol. 28 (4): 219-221 [Abstract] ( 55 ) HTML (30 KB)  PDF  (0 KB)  ( 9 )
222 Clinical application value of urinary catheter bundle nursing
WU Sai-hua;ZHAN Ying-fang;ZHU Jing-ying; SONG Dong-feng;YU Ji-lan;XU Ji-tao
Objective To explore the clinical application value of urinary catheter bundle nursing.Methods A total of 118 patients who received indwelling catheterization in Yingtan People′s Hospital,Jiangxi Province from May 2019 to April 2020 were selected as the subjects of this study.According to the order of admission,the patients were divided into two groups：the reference group (59 cases,routine nursing and sensory control monitoring) and research group (59 cases,cluster nursing and sensory control monitoring).The infection rate,catheter retention time and quality of life of the two groups were compared.Results The total incidence of infection in the research group was 5.08%,which was lower than that in the reference group (22.03%),the indwelling time of catheter in research group was shorter than that in reference group,the differences were statistically significant (P<0.05).Before nursing,there was no significant difference in the quality of life score between the two groups (P＞0.05).After nursing,the quality of life scores such as daily activities,self-care ability and mental state of patients in the research group were higher than those in the reference group,the differences were statistically significant (P<0.05).Conclusion The nursing measures based on the catheter cluster have significant advantages in clinical application,can significantly reduce the clinical infection rate,shorten the catheter retention time,and improve the quality of life of patients,with a certain clinical application value.
2021 Vol. 28 (4): 222-224 [Abstract] ( 43 ) HTML (30 KB)  PDF  (0 KB)  ( 8 )
225 Application effect of emergency nursing process in first aid for patients with acute cerebral infarction
RAO Lu; CHEN Xiao-piao ;LIAO Qiu-hong ;XU Jin-lan
Objective To explore the effect of emergency nursing procedures in first aid for patients with acute cerebral infarction (ACI).Methods A total of 78 ACI patients admitted to the first people′s Hospital of Fuzhou City from January 2018 to January 2019 were selected as the research objects.According to the random number table method,they were divided into the control group (39 cases) and the observation group (39 cases).The control group used traditional nursing care.Based on the control group,the observation group used emergency care procedures to compare the efficiency of first aid and nursing satisfaction between the two groups.In addition,the National Institutes of Health Stroke Scale (NIHSS) was used to assess the degree of neurological impairment in the two groups.Results The referral time and triage evaluation time of the observation group were shorter than those of the control group,and the differences were statistically significant (P<0.05).The scores of health knowledge,disease stability rate and nursing satisfaction of the observation group were higher than those of the control group,and the difference was statistically significant (P<0.05).The NIHSS score of the observation group after nursing was lower than that of the control group,and the difference was statistically significant (P<0.05).Conclusion The implementation of emergency nursing process intervention for ACI patients can improve the efficiency of first aid and treatment,and the satisfaction of patients is high.
2021 Vol. 28 (4): 225-227 [Abstract] ( 55 ) HTML (30 KB)  PDF  (0 KB)  ( 7 )
228 Effect of nursing care on bad mood and quality of life of patients with advanced malignant tumor
YU Fu-jun； FAN Wei-peng▲
Objective To explore the effect of nursing care on the bad mood and quality of life of patients with advanced malignant tumor.Methods From October 2018 to October 2019,a total of 106 patients with advanced malignant tumor treated by Department of Oncology,Anshan Cancer Hospital were selected.They were divided into the Ningyang nursing group and the routine nursing group according to the random drawing lots method,with 53 cases in each group.The routine nursing group adopted the routine nursing measures of tumor patients,while the Ningyang nursing group took the Ningyang nursing intervention in the routine nursing.The changes of bad emotions between the two groups before and after intervention were compared by the self-rating anxiety scale (SAS) and the self-rating depression scale (SDS),and the improvement of quality of life in the two groups after intervention was observed.Results There were no significant difference in SAS and SDS scores between the two groups before intervention (P>0.05).The SAS and SDS scores of the two groups were lower than those before intervention,and the differences were statistically significant (P<0.05).The SAS and SDS scores of Ningyang nursing group were lower than those of routine nursing group,and the differences were statistically significant (P<0.05).There were no significant difference in quality of life scores between the two groups before intervention(P>0.05),and the quality of life scores of the two groups after intervention were lower than those before intervention,and the differences were statistically significant (P<0.05).The quality of life score of the Ningyang nursing group was higher than that of the routine nursing group,and the difference was statistically significant (P<0.05).Conclusion In the nursing care of patients with advanced cancer,the application of nursing care can reduce the anxiety,depression and other bad emotional state,improve the quality of life in the final stage.
2021 Vol. 28 (4): 228-230转234 [Abstract] ( 56 ) HTML (31 KB)  PDF  (0 KB)  ( 6 )
231 Effect of rehabilitation nursing intervention based on demand-oriented concept on swallowing function and quality of life in elderly patients with dysphagia after stroke
YANG Xue-mei； CHEN Xia； SONG Xiao-bei
Objective To explore the effect of rehabilitation nursing intervention based on the demand-oriented concept on swallowing function and quality of life in elderly patients with dysphagia after stroke.Methods A total of 126 elderly patients with dysphagia after stroke in Shanghai Third Rehabilitation Hospital from March 2018 to March 2020 were selected as the research subjects,which were divided into two groups according to the random number table method,with 63 cases in each group.The observation group adopted rehabilitation nursing intervention based on the need-oriented concept,while the control group adopted routine nursing intervention,and they were all nursing for 2 months.The quality of life and swallowing function of the two groups were compared.Results After 2 months of nursing,the scores of the Generic Quality of life Inventory 74 (GQOLI-74) and the Gugging Swallowing Screen (GUSS) in the two groups were higher than those before nursing,the differences were statistically significant.After nursing,the scores of GUSS and GQOLI-74 of the observation group were higher than those of the control group,the differences were statistically significant (P＜0.05).Conclusion Rehabilitation nursing intervention based on the demand-oriented concept can significantly improve the swallowing function of elderly patients with dysphagia after stroke,which is conducive to improving the quality of life of patients.
2021 Vol. 28 (4): 231-234 [Abstract] ( 57 ) HTML (31 KB)  PDF  (0 KB)  ( 9 )
235 Effect of multiple nursing service modes on elderly patients with arrhythmia caused by coronary heart disease
HONG Wei-yan
Objective To explore the impact of multiple nursing service modes on elderly patients with arrhythmia caused by coronary heart disease (CHD).Methods A total of 140 elderly patients with arrhythmia caused by CHD admitted to Tieling Central Hospital in Liaoning Province from January 2019 to January 2020 were selected as the research subjects.According to the random number table method,they were divided into observation group and control group,70 cases in each group.Both groups were treated with Metoprolol Tablets for seven days as a course of treatment,and both groups were treated for two consecutive courses.Besides，patients in the control group received regular nursing service mode intervention,while in the observation group,they received multiple nursing service modes as an intervention.Both groups of patients received nursing intervention for 20 days.The clinical efficacy,health status and complications after the intervention were compared between the two groups.Results The overall response rate of the observation group was 92.86%,higher than that of the control group accounting for 84.29%,the total incidence of complications in the observation group was lower than that in the control group,the differences were statistically significant (P<0.05).Compared with before the intervention in the two groups,the scores of emotion,sleep and consciousness in the two groups were reduced after the intervention,respectively.The scores of emotion,sleep and consciousness in the observation group after the intervention were lower than those of the control group,the differences were statistically significant (P<0.05).Conclusion The application multiple nursing service modes in of arrhythmia caused by CHD in elderly patients can effectively enhance the clinical treatment effect,improve their health status,and reduce the incidence of complications.
2021 Vol. 28 (4): 235-237 [Abstract] ( 53 ) HTML (30 KB)  PDF  (0 KB)  ( 8 )
238 Application effect of PDCA circulation mode in infection control of hospital′s pharmacy intravenous admixture service
LYU Huan
Objective To explore the application effect of PDCA circulation mode in infection control of hospital′s pharmacy intravenous admixture service (PIVAS).Methods The routine management mode adopted in the infection control process of Shenyang Orthopedic Hospital′s intravenous admixture service center from April 2016 to March 2018 was set as the control group,and the PDCA management mode applied in the infection control process of Shenyang Orthopedic Hospital′s intravenous admixture service center from April 2018 to March 2020 was set as the experimental group.There were 6 nurses in each group.The writing quality of nursing documents,service attitude and air sedimentation bacteria in the static distribution center were compared between the two groups.Results The qualified rate of the writing quality of nursing documents,the degree of service satisfaction,the qualified rate of management qualification of inpatient area and bacterial culture qualification rate of the experimental group were higher than those of the control group,the differences were statistically significant (P<0.05).The number of sedimentation bacteria and the rate of sedimentation bacteria in the experimental group were lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion In the control of infection in hospital′s PIVAS,PDCA circulation mode can improve the quality of work,improve the qualified rate of bacterial culture,reduce the rate of sedimentation bacteria,and promote the PIVAS to play its role better.
2021 Vol. 28 (4): 238-240 [Abstract] ( 51 ) HTML (30 KB)  PDF  (0 KB)  ( 9 )
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