Objective To investigate the epidemiological and endoscopic features of peptic ulcer in 2984 patients,and provide a valuable evidence base for clinical practice.Methods The subjects were 2984 patients diagnosed with peptic ulcer by electronic gastroscopy from January to December 2019 in the First People′s Hospital of Changde City,to investigate the influence of season,sex,age and lesion location on the prevalence rate.Results In 2019,24 518 patients underwent gastroscopy in hospital,2984 cases of peptic ulcer were detected,the prevalence was 12.17%,among them,1727 cases were duodenal ulcer (57.88%),975 cases were gastric ulcer (32.67%),241 cases were compound ulcer(8.08%),38 cases were anastomotic ulcer (1.27%),3 cases were Dieulafoy ulcer (0.1%).The detection rate of peptic ulcer was the highest in December (15.38%),the lowest in February (10.29%),the detection rates in autumn and winter were higher than those in spring and summer,the differences were statistically significant(P＜0.05).The ratio of male to female patients with peptic ulcer was 1.97∶1.00,including 1.78∶1.00 for duodenal ulcer,2.05∶1.00 for gastric ulcer,2.95∶1.00 for compound ulcer,18∶1 for anastomotic ulcer and 2∶1 for Dieulafoy ulcer,the prevalence of peptic ulcer in male was higher than that in female,the difference was statistically significant (P＜0.05).The prevalence of peptic ulcer,duodenal ulcer,gastric ulcer and compound ulcer was the highest in the age group of 51-60 years old,the incidence of anastomotic ulcer was the highest in the age group of 61-70 years;The average age of patients with peptic ulcer was(52.46±14.10) years old,among them,the average age of patients with duodenal ulcer was (49.18±14.47) years old,the average age of patients with gastric ulcer was (57.14±12.22) years old,the average age of patients with compound ulcer was (55.73±12.32) years old,the average age of patients with anastomotic ulcer was (60.03±11.30) years old,and the average age of patients with Dieulafoy ulcer was (63.33±10.02) years old.Duodenal ulcer mainly distributed in the bulbar,accounting for 98.26%,and retrobulbar ulcer only accounted for 1.74%.The distribution of gastric ulcer was mainly in antrum,accounting for 56.31%,followed by the stomach angle,stomach body,pyloric duct,stomach fundus and cardia. Conclusion The prevalence of peptic ulcer in changde was 12.17%,mainly in duodenal bulb and gastric antrum ulcer,The incidence of peptic ulcer was closely related to season,gender and age,the highest prevalence was in the age group of 51-60 years old,winter and autumn were the peak incidence of peptic ulcer,and the prevalence rate of male was significantly higher than that of female.

 

Objective To explore the effect of Dexmedetomidine Nasal Drops combined with Dyclonine on the quality of resuscitation of children undergoing transthoracic congenital heart surgery under the trans esophageal echocardiography （TEE).Methods A total of 50 children who underwent TEE-guided transthoracic small incision atrioventricular septal defect closure surgery admitted to the First Affiliated Hospital of Gannan Medical College from June 2017 to August 2019 were selected as the research objects and divided into the control group and the observation group according to random allocation method,with 25 cases in each group.In the control group,Dyclonine was evenly applied to the front 1/3 of the cannula,and 0.5 mL of physiological saline was dripped into the nostril.In the observation group,the front 1/3 of the tracheal intubation was evenly coated with Dyclonine and Dexmedetomidine 2 μg/kg nasal drip.The mean arterial pressure (MAP),heart rate (HR),and arterial blood oxygen saturation （SpO2) at the end of the operation(T0),immediately after extubation (T1),and 5 minutes after extubation (T2) were recorded in the two groups of children,and the recovery time and the occurrence of adverse reactions were compared.Results The MAP and HR at T0,T1,and T2 of the observation group were lower than those of the control group,and SpO2 was higher than that of the control group,The differences were statistically significant (P＜0.05).The total incidence of adverse reactions among children in the observation group was lower than that of the control group,and the difference was statistically significant (P＜0.05).The restlessness score and recovery time of children in the observation group were significantly lower than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion Dexmedetomidine combined with Dyclonine has better quality and higher safety in resuscitation of children with TEE guided transthoracic congenital heart disease than that of single application of Dyclonine,which can be widely promoted in clinic.

 

[Abstract]Objective To explore the clinical effect of Sacubitril Valsartan in treatment of heart failure with reduced left ventricular ejection fraction (LVEF).Methods A total of 80 heart failure patients with reduced left ventricular ejection fraction who were admitted in Pingxiang People′s Hospital from January 2019 to January 2020 were selected as the research subjects and divided into two groups according to random number table method,with 40 cases in each group.The control group was received routine anti-heart failure treatment,and the observation group was treated with Sacubitril Valsartan instead of angiotensin converting enzyme inhibitor and angiotensin Ⅱreceptor blocker (ACEI/ARB).Serum levels of the neuroendocrine system (norepinephrine [NE],aldosterone,angiotensin Ⅱ[AngⅡ],N-terminal probrain natriuretic peptide [NT-proBNP]),cardiac structure (left ventricular end-systolic dimension [LVESD],left ventricular end-diastolic dimension [LVEDD],LVEF) and the Minnesota heart failure quality of life (MHFQL) score were compared between the two groups before treatment and after treatment for 3 months.Results There were no statistical differences in the serum content of neuroendocrine system,cardiac structure,and quality of life between the two groups before treatment (P＞0.05).The NE,aldosterone,AngⅡ,LVESD,LVEDD,NT-proBNP,MHFQL scores in the two groups after treatment for 3 months were higher than those before treatment,and the LVEF was lower than that before treatment；the NE,aldosterone,AngⅡ,LVESD,LVEDD,NT-proBNP and MHFQL scores in the observation group were lower than those in the control group,and the LVEF in the observation group was higher than that in the control group,and the differences were statistically significant (P＜0.05).Conclusion Sacubitril valsartan in treatment of heart failure patients with reduced LVEF can inhibit over-activation of neuroendocrine,prevent and reverse cardiovascular remodeling,increase LVEF,and improve quality of life.

 

Objective To explore the effect of Edaravone therapy on cognitive function and inflammatory factors in elderly patients with vascular dementia.Methods Retrospective analysis was made on the clinical data of 70 elderly patients with vascular dementia admitted to the Fourth Medical Center of the PLA General Hospital from August 2017 to August 2019 were selected as the research object and divided into the test group and the control group according to different treatment methods,with 35 cases in each group.The control group was treated with Memantine Hydrochloride Tablets,and the test group was given Edaravone on the basis of the control group.Both groups treated for 6 weeks.The differences of cognitive function,daily life ability,inflammatory state,total effective rate of treatment and adverse reactions were compared between the two groups.Results After treatment,the mini-mental state examination (MMSE)scores in both groups were higher than those before treatment,the test group MMSE score was higher than that of the control group,and the differences were statistically significant (P＜0.05).After treatment,the activity of daily living(ADL)scores in both groups were lower than those before treatment,the test group ADL score was lower than that of the control group,and the differences were statistically significant (P＜0.05).The levels of interleukin-6 (IL-6) and α tumor necrosis factor (TNF-α) in the test group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant (P＜0.05).No obvious adverse reactions occurred during the treatment period in both groups.Conclusion Edaravone has a significant protective effect on the cognitive function of elderly patients with vascular dementia.It has definite therapeutic effect and high safety,which is suitable for clinical application.

[Abstract]Objective To explore the effect of Creatine Phosphate Sodium combined with Amiodarone on ventricular arrhythmia and its influences on inflammatory factors.Methods A total of 150 patients with ventricular arrhythmia who were admitted to the hospital from March 2017 to October 2019 were selected as the research objects and divided into the observation group(n=75)and the control group(n=75)according to the simple random grouping method.The observation group was treated with Creatine Phosphate Sodium and Amiodarone,while control group was treated with Amiodarone.Both groups were treated for 14 days.The curative effect,heart rate,corrected QT interval (QTc),levels of myocardial injury markers and inflammatory factors,and adverse reactions were compared between the two groups.Results After 14 days of treatment,the total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).After 14 days of treatment,the heart rate in two groups were lower than those before treatment,the QTc in two groups were higher than those before treatment,and the differences were statistically significant (P＜0.05).After 14 days of treatment,heart rate of the observation group was lower than that of the control group,the QTc was higher than that of the control group,and the differences were statistically significant(P＜0.05).After 14 days of treatment,levels of cardiac troponin I (cTnI),creatine kinase MB (CK-MB),brain natriuretic peptide(BNP),serum tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6) and interleukin-8 (IL-8) were lower than those before treatment in both groups,and the differences were statistically significant (P＜0.05).After 14 days of treatment,levels of cTnI,CK-MB,BNP,TNF-α,IL-6 and IL-8 in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Creatine Phosphate Sodium combined with Amiodarone can significantly reduce the levels of serum inflammatory factors,and repair damaged cardiomyocytes.

 

[Abstract]Objective To compare the clinical effect of stent-assisted and double microcatheter in the treatment of intracranial wide-necked aneurysms.Methods A total of 60 patients with intracranial wide necked aneurysms admitted to Huizhou Central People′s Hospital from June 2016 to June 2020 were selected as the research objects,and they were divided into the observation group (30 cases) and the control group (30 cases) according to random number table method.Patients in the observation group were treated with double microcatheter technology,and patients in the control group were treated with stent-assisted treatment.The scores of neurological impairment,life activity scores,hospital stay,prognosis,and incidence of complications were compared between the two groups.Results After treatment,there was no significant difference in neurological deficit score and living activity score between the two groups (P＞0.05).There was no significant difference in the length of stay and prognosis between the two groups (P＞0.05).The total incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant (P＜0.05).Conclusion Stent-assisted and double microcatheter technique can achieve ideal results in the treatment of intracranial wide carotid aneurysms,and the prognosis is good,which can improve the living ability of patients and alleviate the degree of nerve function defect.However,the double microcatheter technique has a lower complication rate,so the safety of this treatment scheme is more prominent,and the appropriate treatment method can be selected according to the actual situation of the patients.

 

Objective To investigate the clinical efficacy of Ticagrelor combined with Aspirin in the treatment of mild acute ischemic stroke.Methods A total of 80 patients with mild acute ischemic stroke admitted to the Second People′s Hospital of Yichun City from July 2019 to June 2020 were selected as the research subjects,and they were divided into the experimental group (40 cases) and the control group (40 cases) according to random number table method.The experimental group was treated with Ticagrelor tablets combined with Aspirin tablets,while the control group was treated with Clopidogrel tablets combined with Aspirin tablets.The degree of neurological impairment and the ability of daily living were compared between the two groups.Results After treatment,the national institutes of health stroke scale(NIHSS) score was lower than that before treatment,and Barthel index was higher than that before treatment,the differences were statistically significant (P＜0.05).After treatment,the NIHSS score of the experimental group was lower than that of the control group,and the Barthel index was higher than that of the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reaction between the two groups (P＞0.05).Conclusion The combination of Ticagrelor and Aspirin in the treatment of mild acute ischemic stroke can reduce the degree of neurological function impairment,improve the independence of patients in daily life,without increasing the toxic and side effects,which is worthy of clinical promotion

 

Objective To investigate the effect of modified electroconvulsive therapy (MECT) combined with repetitive transcranial magnetic stimulation (rTMS) on cognitive function in women patients with severe depression.Methods From January 2018 to February 2020,94 female patients with severe depression who were admitted to Anshan Mental Health Center were selected as the research subjects,and they were divided into two groups according to the random number table method,with 47 cases in each group.The experimental group underwent MECT combined with rTMS,the control group was treated with single MECT.The clinical efficacy,depression status and cognitive function of the two groups were compared.Results The total effective rate of treatment in the experimental group was 93.62%,which was higher than 74.47% in the control group,the difference was statistically significant (P ＜0.05).After treatment,the Hamilton depression rating scale (HAMD) score of the experimental group was (14.29±3.47) points,which was lower than that of the control group for (17.55±3.98) points,the difference was statistically significant (P＜0.05).After treatment,the total number of responses,the number of correct responses and the number of completed classifications of patients in the experimental group were higher than those in the control group,and the number of wrong responses and persistent errors were lower than those in the control group,the differences were statistically significant (P＜0.05).Conclusion MECT combined with rTMS can enhance the curative effect,improve the depressive state,cognitive function and promote the recovery of female patients with severe depression.

 

Objective To analyze the effect of repetitive transcranial magnetic stimulation combined with Escitalopram Oxalate in the treatment of male post schizophrenia depression and its impact on cognitive function.Methods From October 2017 to November 2018,100 male patients with post schizophrenia depression in Kangning Hospital of Chaoyang City,Liaoning Province were selected as the study objects.They were divided into the observation group (n=55) and the control group (n=45) by the random number table method.The control group was treated with Escitalopram Oxalate,and the observation group was treated with repetitive transcranial magnetic stimulation combined with Escitalopram Oxalate.The treatment effect was compared,the scores of negative and positive symptom scale (PANSS),Loewenstein occupational therapy cognitive assessment (LOTCA) and life quality before and after treatment were recorded,and the incidence of adverse reactions during treatment was counted between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group (94.55% vs.80.00%),and the difference was statistically significant (P＜0.05).After treatment,the PANSS and LOTCA scores of the two groups were lower than those before treatment,and those in the observation group ([39.23±4.77],[36.49±5.19]points) were lower than those in the control group ([51.19±4.91],[45.78±5.09]points),the differences were statistically significant (P＜0.05).After treatment,the scores of motivation and energy ([28.12±3.29]points),psychosocial ([18.19±3.02]points),symptoms and adverse reactions ([20.12±4.09]points) in the observation group were lower than those in the control group ([34.12±3.69],[23.15±3.09],[26.24±4.82]points),the differences were statistically significant (P＜0.05).The total incidence of adverse reactions in the observation group (5.45%) was lower than that in the control group(22.22%),and the difference was statistically significant (P＜0.05).Conclusion Repetitive transcranial magnetic stimulation combined with Escitalopram Oxalate in the treatment of male post schizophrenia depression can effectively improve the cognitive function and quality of life of patients,and reduce adverse reactions,the effect is ideal,which can be widely used in clinical practice.

 

Objective To explore the effect of early cranioplasty combined with late cranial repairing in patients with skull defect after craniocerebral trauma.Methods A total of 100 patients with skull defect after craniocerebral trauma admitted in People′s Hospital of Lianshui County from January 2018 to October 2019 were selected as the research subjects.The patients were divided into control group (n=50) and observation group (n=50) by the random number table method.In the control group,late cranial repair was only used,while in the observation group,early cranioplasty combined with late cranial repairing was adopted.The treatment effect,prognosis and Karnofsky performance status (KPS)scores before and after treatment were compared between the two groups.Results There was no statistically significant difference in the KPS score between the two groups before treatment (P＞0.05).The KPS score of the observation group after treatment was higher than that before the treatment,and the difference was statistically significant (P＜0.05).In the control group,the KPS score after treatment was higher than that before,and the difference was statistically significant(P＜0.05).The KPS score of the observation group after treatment was higher than that of the control group,and the difference was statistically significant (P＜0.05).The good prognosis rate of the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).The overall response rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion Early cranioplasty combined with late cranial repairing obtains a significant effect on patients with skull defect after craniocerebral trauma,which can effectively improve the patient′s neurological damage,benefit the patient′s physical rehabilitation,and has a favorable prognosis.It is worthy of vigorous promotion and application.

 

Objective To explore clinical effect of stereotactic tri-ventricular catheterization combined with early external lumbar cistern drainage in the treatment of severe ventricular hemorrhage.Methods The clinical data of 82 patients with severe ventricular hemorrhage admitted to No.7 People′s Hospital of Zibo City from August 2015 to August 2019 were retrospectively analyzed.According to the treatment methods,the patients were divided into the observation group(43 cases) and the control group (39 cases).The observation group was treated with stereotactic catheterization of the third ventricle combined with early lumbar cistern drainage,while the control group was treated with conventional bilateral ventricular puncture and drainage.The clearance time of ventricular hematoma,the indwelling time of ventricular drainage tube,the times of ventricular injection,the incidence of rebleeding,the incidence of intracranial infection and the Glasgow prognostic score (GOS) were compared between the two groups.Results The time of removal of ventricular hematoma and indwelling of ventricular drainage tube in the observation group were shorter than those in the control group,and the times of injecting drugs in the ventricle were less than those in the control group,the differences were statistically significant (P＜0.05).The incidence of recurrent bleeding and intracranial infection in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).GOS score in the observation group was better than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion Early catheterization of the third ventricle combined with lumbar cistern drainage in the treatment of severe ventricular hemorrhage can improve the therapeutic effect,reduce postoperative complications and improve the prognosis.

Objective To investigate the change of event-related potential P300 and its effect on cognitive function in patients with positive non-invasive transcranial Doppler (TCD) foaming test in stroke.Methods A total of 138 stroke patients who received TCD foaming test in Shenyang 242 Hospital from January to December 2019 were selected as the study subjects.Sixty-nine normal patients with negative TCD foaming test were set as the control group,and 69 patients with positive TCD foaming test were set as the observation group.The P300 amplitude,P300 latency,cognitive function and the incidence of migraine were compared and analyzed between the two groups.Results There was no significant difference in P300 amplitude between the two groups (P＞0.05).The latency of P300 in the observation group was longer than that in the control group,the difference was statistically significant (P＜0.05).The proportion of combined cognitive dysfunction in the observation group (18.84%) was higher than that in the control group (5.80%),the difference was statistically significant (P＜0.05).The incidence of migraine in the observation group (69.57%) was higher than that in the control group (26.09%),the difference was statistically significant (P＜0.05).Conclusion Positive TCD foaming test has certain influence on cognitive function of stroke patients,and the prolongation of P300 latency is related to right to left shunt.

 

Objective To explore the correlation of pepsinogen and gastrin-17 (G-17) with chronic renal failure (CRF).Mehtods A total of 100 patients with CRF who were admitted to Clifford Hospital from December 2019 to March 2020 were selected as the research subjects.According to chronickidney disease (CKD) stage,they were divided into group 1(33 cases),group 2 (34 cases) and group 3 (33 cases).Meanwhile,30 healthy people in the same period were selected as the control group.Serum Prothrombin Ⅰ(PGⅠ),serum Prothrombin Ⅱ(PGⅡ),G-17 and renal function were compared among different groups.The Pearson correlation was used to analyze the closeness between PGⅠ,PGⅡ,G-17 and serum creatimine (SCr) in CRF.Results The levels of PGⅠ,PGⅡand G-17 in group 1,2 and 3 were higher than those in the control group,the differences were statistically significant (P＜0.05).The level of PGⅡin group 3 was higher than that in group 1,the difference was statistically significant (P＜0.01).The levels of G-17 in group 2 and 3 were higher than that in group 1,the differences were statistically significant (P＜0.01).The level of G-17 in group 3 was higher than that in group 2,the difference was statistically significant (P＜0.01).The levels of SCr and urea nitrogen(BUN) in groups 1,2 and 3 were higher than those in control group,the differences were statistically significant (P＜0.05).BUN in group 3 was higher than that in group 1,the difference was statistically significant (P＜0.01).BUN in group 2 was higher than that in group 1,the difference was statistically significant (P＜0.05).Serum PGⅠ,PGⅡ,and G-17 levels positively correlated with SCr levels in CFR (P＜0.01).Conclusion Kidney damage may lead to elevated PGⅠ,PGⅡand G-17 levels,which has a certain degree of relation between them.The pepsinogen and gastrin are measurement indicators to reflect the gastric function,which can be used as the screening indicators of gastrointestinal symptoms in patients with chronic renal failure and guide the clinical judgment.

 

[Abstract]Objective To observe the incidence of anxiety and depression in patients with maintenance hemodialysis(MHD) and the relationship between anxiety and depression and the changes of inflammatory cytokines such as interleukin-1 (IL-1),interleukin-6 (IL-6) and C-reactive protein (CRP).Methods A total of 85 patients with MHD who were treated in the blood purification center of Xiangya Hospital Central South University from June 2019 to April 2020 were selected as the research subjects.Self-rating depression scale (SDS) and self-rating anxiety scale (SAS)were used to evaluate their psychological status,and they were divided into non-anxiety group and anxiety group,nondepression and depression group according to the results.The levels of IL-1,IL-6 and CRP in patients with different anxiety and depression were compared.Results In 85 MHD patients,the incidence of anxiety and depression were 41.1% and 68.2%.IL-1,IL-6 and CRP in the anxiety group were higher than those in the non-anxiety group,the differences were statistically significant (P＜0.05).IL-1,IL-6 and CRP in the depression group were higher than those in the non-depression group,the differences were statistically significant (P＜0.05).Conclusion The incidence of anxiety and depression is higher in MHD patients with maintenance hemodialysis,which is related to the expression of inflammatory cytokines IL-1,IL-6 and CRP.

 

Objective To observe the effect of percutaneous nephroscope surgery on patients with ureteral calculi and the effect on renal function and complications.Methods A total of 60 patients with ureteral calculi who were admitted to the Fifth People′s Hospital of Liaoyang City from January 2019 to January 2020 were selected as the research subjects.They were randomly divided into control group (30 cases) and intervention group (30 cases).The control group adopted ureteroscopic surgery for stone removal for treatment,the intervention group was treated with percutaneous nephroscope surgery.The stone removal rates,operation status,renal function and complications of the two groups were compared.Results The stone clearance rate of the intervention group was higher than that of the control group,the operation time was shorter than that of the control group,the intraoperative blood loss was more than that of the control group,and the hospital stay was longer than that of the control group,the differences were statistically significant (P＜0.05).The levels of creatinine (Cr),glomerular filtration rate (GFR),cystatin C (Cys-C),blood urea nitrogen (BUN),and lipocalin (NGAL) in the two groups after surgery were lower than those before surgery,the differences were statistically significant (P＜0.05).The levels of Cr and NGAL after surgery in the two groups were lower than those before surgery,while the levels of GFR,Cys-C and BUN were higher than those before surgery,the differences were statistically significant (P＜0.05).The level of Cys-C in intervention group was lower than that in the control group,and the level of NGAL in intervention group was higher than that in the control group,the differences were statistically significant (P＜0.05).The total incidence of complication in that intervention group was lower than that in the control group,the difference was statistically significant (P＜0.05).Conclusion Percutaneous nephroscope surgery is effective in treating patients with ureteral calculi,which can effectively remove calculi,improve renal function,and reduce complications.It is worthy of popularization and application.

 

Objective To investigate the application of multimodal analgesia based on the concept of accelerated rehabilitation surgery in transurethral resection of prostate.Methods A total of 160 patients who underwent transurethral resection of prostate for prostatic hyperplasia in the Second People′s Hospital of Neijiang City from January 2017 to December 2018 were selected as the research objects and divided into the control group and the study group according to random number table method,with 80 cases in each group.The control group was treated with postoperative analgesia pump,and the observation group was treated with multi-mode analgesia.The incidence of bladder spasm,visual analog scale (VAS) score,dosage of non-steroidal analgesic drugs,the incidence of adverse reactions to analgesic drugs and postoperative recovery were compared between the two groups.Results The frequency of postoperative bladder spasm in observation group was less than that in control group,duration of postoperative bladder spasm was shorter than that in control group,the VAS score was lower than that in the control group,and the differences were statistically significant (P＜0.05).The amount of intraoperative,postoperative and total non-steroidal analgesic drugs in observation group were lower than those in control group,and the differences were statistically significant (P＜0.05).The total incidence of postoperative analgesic drugs in observation group was lower than that in control group,and the difference was statistically significant(P＜0.05).Postoperative activity time,exhaust time and discharge time in observation group were shorter than those in control group,and the differences were statistically significant (P＜0.05).Conclusions The combined application of multimodal analgesia can improve the analgesic effect of patients undergoing electrotomy of prostate,reduce adverse anesthetic reactions,and accelerate the postoperative rehabilitation process of patients.

 

Objective To analyze the effect of Dezocine on the median effective dose (ED50) of Etomidate-Propofol mixture (EP mixture) and its efficacy and safety in painless gastroscopy.Methods A total of 60 patients who undergoing painless gastroscopy in Shunde Hospital of Southern Medical University from June 2019 to June 2020 were selected and divided into the Dezocine group and the control group according to random number table method,with 30 cases in each group.Patients in the Dezocine group received intravenous Dezocine 50 μg/kg before the EP mixture,and patients in the control group received only the EP mixture for anesthesia.The incidence of adverse reactions such as hypotension,injection pain,muscle tremor,nausea and vomiting,the time to reach the target anesthesia depth,the time to wake up,the time to leave the room,the time spent in examination and the ED50 were compared between the two groups during painless gastroscopy.Results The incidence of adverse reactions such as hypotension,injection pain,muscle tremor,nausea and vomiting in Dezocine group were lower than those in control group,and the differences were statistically significant (P＜0.05).The time to reach the target anesthetic depth in Dezocine group was shorter than that in control group,and the difference was statistically significant (P＜0.05).The ED50 of Dezocine group was lower than that of control group,and the difference was statistically significant (P＜0.05).Conclusion The use of Dezocine compound EP mixture has obvious effect on inhibiting visceral pain reaction in painless gastroscopy,which can effectively save the amount of drugs,reduce the social burden,reduce the incidence of adverse reactions and improve medical safety.It has good social value and is worthy of application in clinical practice.

Objective To incestigate the application of epidural catheter spiral fixation in labor analgesia.Methods A total of 200 parturients who vaginal delivery and voluntary implementation of labor analgesia (gestational age ≥37 weeks) were selected as the study objects and divided into the S group and the L group according to random number table method,with 100 cases in each group.In group S,the epidural catheter was fixed in a spiral manner (the epidural catheter was folded in a spiral manner at the puncture site for two circles) and the catheter joint was extended to the neck by sticking to the skin,while in group L,the epidural catheter was fixed in a straight manner and the catheter joint was extended to the neck by sticking to the skin.The cases of complete epidural catheter prolusion,the length of indwelling epidural catheter in vivo at the beginning and end of labor analgesia,and the visual analog scale (VAS)scores at the most severe stage of labor before and after labor analgesia were compared between the two groups.Results There was no statistically significant difference in the cases of epidural catheter completely proluding the epidural space between the two groups (P＞0.05).After labor analgesia,the indwelling length of epidural catheter in group S was greater than that in group L,and the difference was statistically significant (P＜0.05).There were no significant differences in the VAS scores before and after analgesia in the first stage of labor and the second stage of labor (P＞0.05).Conclusion Spiral fixation of epidural catheterization can reduce the length of epidural catheter prolapse and maintain the analgesic effect of epidural labor.

Objective To explore the application value of color Doppler ultrasound in detecting uterine artery blood flow spectrum at middle and advanced stage in pregnancy-induced hypertension syndrome (PIH).Methods A total of 100 pregnant women at middle and advanced stage admitted to Fuzhou Maternal and Child Health Center from May 2018 to April 2020 were selected.They were divided into the normal pregnancy group (n=50) and the PIH group (n=50) according to the follow-up results,and they were all provided with color Doppler ultrasound blood flow spectrum test.The blood flow spectrum test results,the positive rate of each index and the level of each index of patients in different types were compared between the two groups.Results Resistance index (RI),arterial pulsatility index (PI),the ratio of fetal umbilical artery systolic blood pressure to diastolic blood pressure (S/D) in the PIH group were higher than those in the normal pregnancy group (P＜0.05).The positive rates of RI,PI and S/D in the PIH group were higher than those in the normal pregnancy group (P＜0.05).The RI,PI and S/D values of patients with eclampsia were higher than those of patients with preeclampsia and hypertension during pregnancy (P ＜0.05).The RI,PI,and S/D values of preeclampsia were higher than those of hypertension during pregnancy (P＜0.05).Conclusion Color Doppler ultrasound detection of uterine artery blood flow spectrum at middle and advanced stage pregnancy has a good application value in PIH,which can provide a good basis for clinicians to predict and evaluate PIH,and is worthy of promotion.

Objective To compare the safety and economy of oral and intravenous iron supplementation under the guidance of clinical pharmacists.Methods The clinical data of 224 perioperative patients with mild to moderate iron deficiency anemia admitted to the Gynecology Department of Nanjing Maternal and Child Health Hospital from January 2016 to December 2019 were retrospectively analyzed.All patients were treated with pharmaceutical intervention by clinical pharmacists,and were divided into the oral iron group (119 cases) and the intravenous iron group (105 cases)according to different treatment methods.The oral iron group was supplemented with oral iron,and the intravenous iron group was supplemented with intravenous iron sucrose and oral iron.Blood transfusion rate,postoperative infection rate,postoperative cardiac function changes,Class A incision healing rate,ICU occupancy rate,total days of hospital stay,readmission rate and drug cost were compared between the two groups.Results There was no significant difference in blood transfusion rate between the two groups (P＞0.05).There were no significant differences in postoperative infection rate,postoperative cardiac function change,Class A incision healing rate,ICU occupancy rate (case fatality rate),total length of stay,7 d and 30 d readmission rate between the two groups (P＞0.05).The total cost of anemia treatment in intravenous iron group was higher than that in oral iron group,and the difference was statistically significant (P＜0.05).Conclusion Oral iron supplementation can effectively correct iron deficiency and anemia,with better safety,and more economical benefits,which provides strong support for subsequent pharmaceutical interventions.

 

Objective To investigate the clinical effectiveness of Morphine Sulfate Sustained Release Tablets and Cinobufagin Capsules in the treatment of advanced liver cancer.Methods A total of 60 patients with advanced liver cancer admitted to the Department of Oncology in the Ji′an First People′s Hospital from January 2018 to July 2020 were selected as the analysis subjects,and they were randomly divided into the reference group (30 cases) and the experimental group (30 cases) according to their serial numbers.The reference group was treated with routine chemotherapy combined with Morphine Sulfate Sustained Release Tablets.The experimental group was treated with routine chemotherapy combined with Morphine Sulfate Sustained Release Tablets and Cinobufagin Capsules.The total effective rate,Karnofsky life function assessment scale (KPS) and Chinese version of numeric rating analog pain scale(NRS) scores were compared between the two groups,and the total incidence of adverse reactions was compared between the two groups.Results The total effective rate of experimental group (93.33%)was higher than that of reference group (63.33%),and the difference was statistically significant (P＜0.05).Before treatment,there were no statistical significance in KPS and NRS scores between the two groups (P＞0.05).After treatment,the KPS scores of two groups were higher than those before treatment,the NRS scores of two groups were lower than those before treatment,the KPS score of experimental group was higher than that in the control group,and the NRS score of experimental group was lower than that in the control group,the differences were statistically significant (P＜0.05).There was no statistical significance in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion The combination of Morphine Sulfate Sustained Release Tablets and Cinobufagin Capsules in the treatment of patients with advanced liver cancer has significantly enhanced the functional recovery and pain relief of patients,and has less adverse reactions in clinical application,which is worthy of promotion.

Objective To explore the effect and safety of compound Azinmide combined with Mosapride in the treatment of gastrointestinal disease-related dyspepsia in the elderly.Methods A total of 100 elderly patients with gastroenteric-related dyspepsia admitted to the Geriatric Department of Ganzhou People′s Hospital from January 2018 to January 2020 were selected and divided into the combined group (50 cases) and the control group (50 cases) according to the random number table method.The combined group was treated with compound Azinomide combined with Mosapride,while the control group was treated with Mosapride alone.The symptom score,quality of life score,clinical efficacy,symptom disappearance time,length of hospital stay and the incidence of adverse reactions were compared between the two groups.Results After treatment,the severity score and symptom frequency of both groups were lower than those before treatment,and the combined group was lower than those of the control group,the differences were statistically significant (P＜0.05).After treatment,quality of life scores of the two groups were higher than that before treatment,and the combined group was higher than that of the control group,the differences were statistically significant (P＜0.05).The total effective rate of the combined group was higher than that of the control group,and the difference was statistically significant (P＜0.05).The time of symptom disappearance and hospital stay in the combined group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).There was no statistical significance in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Compound Azinomide combined with Moxapride has significant efficacy and high safety in the treatment of gastrointestinal disease-related dyspepsia in the elderly.

Objective To explore the clinical effect of Magnesium sulfate combined with Nifedipine in the treatment of pregnancy-induced hypertension syndrome.Methods A total of 100 patients with pregnancy hypertension syndrome admitted to Huangshi Love and Health Hospital from January 2017 to December 2019 were selected as the research objects and divided into the control group (50 cases) and the intervention group (50 cases) according to random number table method.The control group was selected Magnesium sulfate was used for treatment.The control group was treated with Magnesium sulfate,and the intervention group was treated with Magnesium sulfate combined with Nifedipine.The total effective rate,blood pressure changes,24 h urinary protein quantification and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the intervention group was higher than that of the control group,the difference was statistically significant (P＜0.05).After treatment,diastolic blood pressure,systolic blood pressure and 24 h urinary protein levels in the intervention group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The total incidence of adverse reactions in the intervention group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion Magnesium sulfate combined with Nifedipine in the treatment of pregnancy hypertension syndrome has significant clinical effect,can improve the total effective rate of treatment,reduce blood pressure,relieve proteinuria,worthy of promotion and application.

Objective To study the clinical effect of Omeprazole combined with Octreotide in the treatment of senile cirrhosis with upper gastrointestinal bleeding.Methods A total of 80 elderly patients with cirrhosis and upper gastrointestinal bleeding treated in the Fourth People′s Hospital of Shenyang City from March 2018 to March 2020 were selected as study subjects,and were divided into the observation group and the control group by the randomized sortition grouping principle,with 40 patients in each group.Patients in the observation group were treated with Omeprazole combined with Octreotide,while patients in the control group were treated with conventional treatment.The lengths of hospital stay,hemostatic time,total incidence of adverse events,blood transfusion volumes,total effective rate,hematemesis disappearance time and melena disappearance time were compared between the two groups.Results The length of hospital stay and hemostatic time of the observation group were shorter than those of the control group,and the blood transfusion volume was less than that of the control group,the differences were statistically significant (P＜0.05).The total effective rate of the observation group was higher than that of the control group,with statistically significant difference (P＜0.05).The total incidence of adverse events in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).The hematemesis symptom disappearance time and melena symptom disappearance time in the observation group were shorter than those in the control group,with statistically significant differences (P＜0.05).Conclusion The combination of Omeprazole and Octreotide in elderly patients with cirrhosis and upper gastrointestinal bleeding has achieved a high effective rate.It is worthy of clinical promotion.

Objective To investigate the clinical effect of the treatment of slow transit constipation (STC) of spleenkidney yang deficiency by supplementing fire and creating earth combined with thermosensitive moxibustion.Methods A total of 80 STC patients with spleen and kidney yang deficiency type who were admitted to Jiujiang Hospital of Traditional Chinese Medicine from January 2019 to June 2020 were selected and divided into the treatment group and the control group by random number table method,with 40 cases in each group.The treatment group was treated with supplementing fire and creating earth combined with thermosensitive moxibustion,and the control group was treated with Mosapride Citrate Tablets.Both groups were treated for 30 days.The curative effect,traditional Chinese medicine (TCM)syndrome score and the total incidence of adverse reactions were compared between the two groups.Results The total effective rate in the treatment group was higher than that in the control group,and the difference was statistically significant (P＜0.05).After 30 days of treatment,TCM syndrome scores in both groups were lower than those before treatment,and TCM syndrome scores in the treatment group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The total incidence of adverse reactions in the treatment group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The method of supplementing fire and creating earth combined with thermosensitive moxibustion in the treatment of STC patients with spleen and kidney yang deficiency can effectively improve constipation,with high safety,and is worthy of promotion.

Recurrent oral ulcer is a common disease that occurs in the oral mucosa.Western medicine believes that its incidence is related to many factors,while traditional Chinese medicine believes that it is mainly related to the "fire"evil.The cause is mostly divided into actual fire and virtual fire.Its main pathogenesis is the spleen and stomach rise and fall dysfunction,qi disorder,yin and yang are out of balance,the disease is mainly in the mouth,spleen and stomach,involving the heart,liver and kidney.There is currently no specific treatment plan for treatment.Western medicine focuses on symptomatic and etiological treatment.However,the treatment effect of single western medicine is not significant and the disease is easy to recur.The individualized treatment plan of traditional Chinese medicine has played a great advantage,and the treatment plan of integrated traditional Chinese and western medicine has been in recent years and highly respected.In the clinic,Professor YANG Xiao-jun uses the combination of prescription and western medicine to treat patients with recurrent oral ulcers through specific syndrome differentiation and treatment.The author summarizes professor YANG Xiaojun′s experience in treating recurrent oral ulcers and shares a specific medical record with other doctors.

Objective To investigate the clinical effect and advantages of acupoint catgut embedding in the treatment of hyperlipidemia with abnormal liver function.Methods A total of 78 patients with hyperlipidemia and abnormal liver function who were treated in Dongzhimen Hospital (Tongzhou Branch),Beijing University of Chinese Medicine from June 2017 to June 2020 were selected as the research subjects,and they were divided into observation group (n=39)and control group (n=39) by the random number table method.The observation group was treated with acupoint catgut embedding method,and the control group was treated with oral Xuezhikang Capsules.The efficacy,blood lipid,body weight and liver function indexes of the two groups were compared,and the incidence of adverse reactions in the two groups was compared.Results There was no significant difference in curative effect between the two groups (P＞0.05).After treatment,the serum total cholesterol (TC),triacylglycerol (TG),low-density lipoprotein cholesterol (LDL-C),body weight,alanine aminotransferase (ALT),and aspartate aminotransferase (AST) in the observation group were lower than those before treatment,and the differences were statistically significant (P＜0.05).The TG,body weight,ALT and AST of the observation group were lower than those of the control group after treatment,and the differences were statistically significant (P＜0.05).No adverse reactions occurred in the observation group.The incidence of adverse reactions in observation group was lower than that in the control group,with statistical significance (P＜0.05).Conclusion In the treatment of patients with hyperlipidemia and abnormal liver function,acupoint catgut embedding and oral administration of Xuezhikang Capsules have a great lipid-lowering effect.However,acupoint embedding is better than oral administration of Xuezhikang Capsules in weight reduction and liver function improvement,and there is no adverse reaction.

Objective To explore the application of traditional Chinese medicine acupoint application combined with sham feeding in promoting gastrointestinal function recovery after laparoscopic choledocholithotomy.Methods A total of 60 patients who underwent laparoscopic choledocholithotomy in Jiangxi Pingxiang People′s Hospital from November 2018 to June 2020 were selected as the research objects.According to the random number table method,they were divided into the blank group,the control group and the observation group,with 20 cases in each group.Patients in blank group were treated with conventional postoperative treatment,patients in control group were treated with conventional treatment combined with sham feeding,and patients in observation group were treated with Zusanli ructus evodia paste combined with sham feeding.The recovery of gastrointestinal function and the total incidence of complications in the three groups were compared.Results After treatment,the time of first bowel sounds,first anal exhaust,first defecation and first hospital stay in the control group were shorter than those in the blank group,while the time of first bowel sounds,first anal exhaust,first defecation and first hospital stay in the observation group were shorter than those in the control group and the blank group,the differences were statistically significant (P＜0.05).The total incidence of complications after treatment in the control group was lower than that in the blank group,and the total incidence of complications in the observation group was lower than those in the control group and the blank group,the differences were statistically significant (P＜0.05).Conclusion The use of traditional Chinese medicine acupoint application combined with sham feeding can promote the recovery of gastrointestinal function of patients after laparoscopic choledochectomy,shorten the hospital stay,and reduce the incidence of complications with a remarkable effect.

Objective To observe the efficacy of Intraarticular Hyaluronic Acid (IHA) injection combined with Traditional Chinese Medicine in the treatment of ankle synovitis.Methods From January 2019 to December 2019,a total of 90 patients with ankle synovitis treated in the Department of Orthopedics and Traumatology of Yichun Traditional Chinese Medicine Hospital were selected and divided into three groups by random number table method,with 30 cases in each group.Group A was treated with simple anti-inflammatory and analgesic treatment,Group B was treated with traditional Chinese medicine fumigation combined with washing,Group C was treated with IHA combined with traditional Chinese medicine fumigation and washing,30 days was a course of treatment,and the three groups were treated with 1 course of treatment.The clinical effects of the three groups at 1,3,and 6 months after treatment were compared;the inflammatory indexes (interleukin-1 [IL-1],tumor necrosis factor-α[TNF-α]) of the three groups before treatment and after one course of treatment were compared.Results After 1,3,and 6 months of treatment,the excellent and good rate of clinical treatment in Group C was higher than that in Group B,and Group B was higher than Group A,the differences were statistically significant (P＜0.05).Before treatment,the levels of IL-1,TNF-αwere compared among three groups,the difference was not statistically significant (P＞0.05).After one course of treatment,the levels of IL-1 and TNF-α in three groups were lower than before treatment,and the levels of IL-1 and TNF-α in Group C were lower than those in Group A and Group B,the levels of IL-1 and TNF-α of Group B were lower than Group A,the differences were statistically significant (P＜0.05).Conclusion IHA combined with traditional Chinese medicine fumigation and washing has a good effect in the treatment of ankle synovitis,it can effectively improve the ankle joint function,reduce the level of inflammation,and promote the recovery of the patient.

Objective To investigate the clinical effect of narrow-band ultraviolet B (NB-UVB) combined with Bailing tablets and Compound Kalizirin Tincture in the treatment of vitiligo.Methods A total of 92 patients with vitiligo in Shenyang Seventh People′s Hospital from January 2018 to January 2020 were selected and randomly divided into two groups,46 cases in each group.The control group was treated with Bailing tablets and Compound Kalizirin Tincture,and the observation group was treated with NB-UVB on the bases of the control group.The clinical efficacy,immune function and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 89.13%,which was higher than 71.74% of the control group,the difference was statistically significant(P＜0.05).There was no significant difference in immune function between the two groups before treatment (P＞0.05);after treatment,CD4+,CD4+/CD8+ in the two groups were higher than those before treatment,and CD8+ were lower than those before treatment,the differences were statistically significant (P＜0.05);after treatment,CD4+,CD4+/CD8+ in the observation group was higher than that in the control group,CD8+ was lower than that in the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion NB-UVB combined with Bailing tablets and Compound Kalizirin Tincture can improve the clinical efficacy of vitiligo patients,improve the immune function of the body,and promote the regression of leukoplakia,it is safe and reliable.

Objective To investigate the effect of Huanglian Shangqing Capsule combined with Minocycline in the treatment of chronic periodontitis on the periodontal condition and inflammation.Methods A total of 88 patients with chronic periodontitis admitted to Dental Prophylactico-Therapetic Institution in Dadong District of Shengyang from April 2018 to April 2020 were selected.They were divided into two groups according to a random number table,with 44 cases in each group.In the control group,Minocycline was alone used,and in the observation group,Huanglian Shangqing Capsule was added.The periodontal indicators,inflammatory factor levels and adverse reactions were compared between the two groups.Results After treatment,the gingival crevicular bleeding index (SBI),plaque index (PLI),gingival index (GI),and periodontal pocket depth (PD) of the observation group were lower than those of the control group,and the differences were statistically significant (P＜0.05).After treatment,the levels of interleukin (IL)-1β,IL-6,and tumor necrosis factor-α (TNF-α) of the observation group were lower than those in the control group,with statistical significance (P＜0.05).There was no statistically significant difference in total incidenced adverse reactions between the two groups (P＞0.05).Conclusion Huanglian Shangqing Capsule combined with Minocycline can enhance the treatment effect of chronic periodontitis,improve the periodontal index of patients,reduce oral inflammation damage,and promote the improvement of the condition,it is safe and reliable.

Objective To investigate the influence of standardized pelvic floor rehabilitation management on pelvic floor muscle strength,urinary incontinence and quality of life (QOL) in pregnant and delivery women.Methods A total of 92 cases of pregnant and delivery women admitted to Houjie Hospital of Dongguan City from January to June 2020 were selected as study subjects.According to the random number table method,they were divided into the control group (46 cases) and the study group (46 cases).Conventional pelvic floor rehabilitation management was adopted in the control group,while standardized pelvic floor rehabilitation management was adopted in the study group.The pelvic floor muscle strength,urine leakage and QOL score of the two groups were compared.Results The pelvic floor muscle strength of the study group was better than that of the control group,and the difference was statistically significant (P＜0.05).The urine leakage in the study group was less than that in the control group,and the difference was statistically significant (P＜0.05).There were no significant differences in the QOL scores of the two groups before management (P＞0.05).The QOL scores of the study group after management were higher than those of the control group,with statistically significant difference (P＜0.05).The QOL scores of the two groups after management were both higher than those before management,with statistically significant difference (P＜0.05).Conclusion For pregnant and delivery women,the application of standardized pelvic floor rehabilitation management can effectively enhance the pelvic floor muscle strength,improve the symptoms of urinary incontinence,and improve the QOL of pregnant and delivery women,which is worth further promotion and application in clinical practice.

Objective To investigate the influence of peripherally inserted central catheters (PICC) network maintenance on intermittent infection of PICC in tumor chemotherapy patients.Methods From November 2018 to November 2019,97 patients with malignant tumor who underwent chemotherapy in Anshan Cancer Hospital were selected.They were divided into the control group group (n=48) and the study group (n=49) according to the random number table method.Routine catheterization was performed in the control group,the study group was given PICC network maintenance.The maintenance period and PICC retention time between the two groups were compared,and the occurrence of PICC related infections in the two groups was monitoried and counted.Results The maintenance period of the patients in the study group was shorter than that in the control group,while the PICC retention time in the study group was longer than that in the control group,the differences were statistically significant (P＜0.05).The incidence of PICC related infection in the study group was 4.08%,which was lower than that in the control group group (18.75%),the difference was statistically significant (P＜0.05).Conclusion PICC network maintenance can improve the PICC maintenance effect of tumor chemotherapy patients,reduce the incidence of intermittent infection and prolong the PICC retention time.

The pharmaceutical majors of higher vocational colleges aim to cultivate application-oriented talents with advanced technical skills in drug research and development,production,inspection,sales,and use.The pharmaceutical majors should take compound talents as the training goal and focus on the shaping of lifelong learning ability and the ability to transfer professional positions because of the diversified job group.Combining the vocational education reform and development direction of "school-enterprise cooperation,integration of production and education" in pharmaceutical majors,our school integrates the relevant content of the "1+X" vocational skill level certificate standard,and initially established the collaborative innovation of the school and enterprise to cultivate diversified professional talent training model.Under the guidance of this model,the curriculum system of "course post-certificate accomodation" for pharmacy specialty in higher vocational jointly participated by schools and enterprises has been initially constructed.

Objective To explore the application of the "317 Nursing" electronic education platform in patients with uterine fibroids,in order to strengthen clinical patients′ awareness of health education and improve the quality of care.Methods A total of 92 patients with uterine fibroids admitted to Women and Children′s Hospital of Xiamen from September 2018 to May 2019 were selected as the research objects,and they were divided into 2 groups according to the random double-blind method,with 46 cases in each group.The control group implemented routine education and the observation group implemented the "317 Nursing" electronic platform education.After 10 days of intervention,the two groups′ health education knowledge and nursing service satisfaction were compared.Results There was no statistically significant difference between the two groups of health education knowledge mastery questionnaire scores before intervention（P＞0.05）;The health education knowledge mastery questionnaire scores of the two groups after intervention were higher than those before intervention,the differences were statistically significant （P＜0.05）;The health education knowledge mastery questionnaire score of the observation group after intervention was higher than that of the control group,the difference was statistically significant （P＜0.05）;The nursing service satisfaction questionnaire score of the observation group was 93.48%,which was higher than that of the control group 73.91%,the difference was statistically significant （P＜0.05）.Conclusion The using of "317 Nursing" electronic platform for health education knowledge in patients with uterine fibroids can effectively improve patients′ awareness of health education and increase patients′ satisfaction with clinical care.

Objective To explore the application of whole-course health education in the perioperative period of glaucoma patients complicated with uremia.Methods A total of 36 patients with glaucoma complicated with uremia admitted to North Guangdong People′s Hospital Affiliated to Shantou University from February 2017 to February 2020 were selected as the research objects.According to the order of admission time,the patients were randomly divided into the control group (18 cases) and the research group (18 cases).The control group adopted the conventional perioperative health education method,and the the research group adopted the overall health education method based on the conventional perioperative health education.The satisfaction,awareness of health knowledge and postoperative intraocular pressure level between the two groups were compared.Results The health knowledge awareness scores of the two groups of patients after the intervention were higher than those before the intervention,and the patients′ health knowledge and nursing satisfaction of the study group were higher than those of the control group,and the differences were statistically significant (P＜0.05);The intraocular pressure (IOP) after the intervention was lower than before the intervention,and the IOP after the study group was lower than the control group,the differences were statistically significant (P＜0.05).Conclusion Comprehensive health education for patients with glaucoma complicated with uremia during perioperative period can improve patients′ health knowledge,nursing satisfaction and surgical treatment effect,which is worthy of clinical promotion and application.

Objective To explore the application value of Fanshenjin in children after scoliosis,to provide a reference for the formulation and adjustment of clinical nursing measures and the prognosis of children.Methods A total of 44 children who underwent scoliosis surgery in Jiangxi Province Children′s Hospital from January 2015 to June 2020 were selected as the research subjects.They were divided into control and observation groups by random number table method,with 22 cases in each group.The control group′s children were given routine nursing intervention + comprehensive nursing intervention,and the observation group′s children applied the Fanshenjin on the basis of the control group,and all intervened for 1 week.The pain (visual analogue scale [VAS]),comfort (general comfort questionnaire[GCQ]) and complication incidence were compared between the two groups.Results When patients got out of bed for the first time after operation,VAS score of observation group was lower than that of control group,and GCQ score was higher than that of control group,the differences were statistically significant (P＜0.05).There was no significant difference in the incidence of pressure ulcer between the two groups (P＞0.05).Conclusion The Fanshenjin has a good effect after the operation of children with scoliosis,which can relieve the pain and improve the comfort of the children without increasing the risk of pressure ulcers.

Objective To explore the application effect of modified indwelling needle fixation method in pediatric patients.Methods A total of 100 children hospitalized in the Department of Pediatrics,the Second People′s Hospital of Jingdezhen from December 2018 to December 2019 were selected as the research subjects.According to the order of admission method,the children were equally divided into experimental group and control group,with 50 cases in each group.The pain degree,family satisfaction,indwelling time of indwelling needle,indwelling needle cose and complications of the two methods were compared.Results The incidence of accidental catheter removal,drug solution extravasation and pressure injury in the experimental group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The indwelling time of indwelling needle in experimental group was longer than that in the control group,and the difference was statistically significant (P＜0.05).The scores of visual analogue scale (VAS)and nursing satisfaction scale (SNCS) in the experimental group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The in dwelling needle cost of the experimental group were lower than those of the control group,and the difference was statistically significant (P＜0.05).Conclusion This study improved needle fixed method has satisfactory effect in pediatric clinic,compared with the traditional fixed method.The improved fixation method can reduce the incidence of accidental damage to take off the tube and pressure,etc.Plays an important role in clinical intervention,to reduce the pain of children take,ensures adherence to children,is a scientific and effective means of fixed,and has clinical value.

Objective To investigate the effect of rehabilitation nursing on mental condition and activity of daily living in patients with brain trauma.Methods The clinical data of 80 patients with brain trauma who were admitted to Shangrao People′s Hospital,Jiangxi Province from March 2019 to March 2020 were retrospectively analyzed.The clinical data of 40 patients with routine nursing were classified in the control group,and the clinical data of 40 patients with routine nursing and rehabilitation nursing were classified in the observation group.The mental condition,score of activity of daily living scale (ADL),and nursing satisfaction were compared between the two groups.Results The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in the two groups before intervention,the difference had no statistical significance (P＞0.05).The scores of SAS and SDS in the two groups after intervention were lower than those before intervention,and the scores of SAS and SDS in the observation group were lower than those of the control group,with statistically significant differences (P＜0.05).The score of ADL in observation group was higher than that in the control group after intervention,with statistically significant difference (P＜0.05).The nursing total satisfaction of observation group was higher than that of the control group after intervention,with statistically significant difference (P＜0.05).Conclusion Rehabilitation nursing in patients with brain trauma has better effects,it can relieve anxiety and depression,improve activity of daily living,and increase nursing satisfaction of patients.

Objective To explore the influence of empowerment guidance on the care ability of family caregivers of long-term hospitalized stroke patients.Methods A total of 80 cases family caregivers of stroke patients in the Seventh People′s Hospital of Nanhai District,Foshan City from June to December 2019 were selected and divided into two groups according to random number table method,40 cases in each group.The control group was given routine nursing,while the observation group was given empowerment guidance on the basis of the control group.The care readiness and care ability of the two groups were compared.Results There was no significant difference between the two groups before intervention in caregiver preparedness scale (CPS) score (P＞0.05).After 3 months of intervention,the CPS score of the observation group was (22.36±4.37) points,which was higher than that of the control group of (18.22±3.79) points,the difference was statistically significant (P＜0.05).There was no significant difference in the score of family caregiver task inventory (FCTI) between the two groups before intervention (P＞0.05);after 3 months of intervention,the observation group scores were (2.24±0.71) points in response and assistance,(2.08±0.87) points in adapting to care roles,(1.24±0.55) points in dealing with personal emotions,(1.18±0.35) points in adjusting life to meet care needs,and evaluating family and community The score of resource was (1.38±0.42) points,lower than those of the control group of (2.65±1.02),(3.30±1.04),(2.26±1.08),(1.71±0.47),(1.98±0.71) points,and the differences were statistically significant (P＜0.05).Conclusion Empowerment guidance applied to family caregivers of long-term hospitalized stroke patients has positive significance to improve their care preparation and care ability,and can be widely used.

Objective To explore the application effect of comprehensive nursing model in critically ill patients with continuous blood purification at bedside.Methods From April 2018 to March 2020,60 critically ill patients with continuous blood purification at the bedside admitted to the Fuzhou First People′s Hospital were selected as the research objects.According to the random number table method,they were divided into the observation group and the control group,30 cases in each group.The control group used traditional nursing intervention.and the observation group used comprehensive mode of intervention.The length of hospital stay,the total incidence of complications and the total satisfaction of nursing were compared between the two groups.Results The quality of life and nursing total satisfaction of the observation group were higher than those of the control group,the total complication rate of the observation group was lower than that of the control group,the length of stay in the observation group was shorter than that of the control group,the differences were statistically significant (P＜0.05).Conclusion Adopting a comprehensive nursing model for critically ill patients with continuous blood purification at the bedside is beneficial to prevent and reduce the occurrence of complications,shorten the length of hospitalization,and improve nursing satisfaction.It is worthy of popularization and application.

Objective To explore the effect of high quality nursing intervention based on humanistic care in elderly patients with severe pneumonia.Methods From January 2019 to December 2019,86 elderly patients with severe pneumonia treated in Dalian Port Hospital were selected.They were divided into routine group and study group according to their order of visits,43 cases in each group.The routine group carried out routine nursing measures during the symptomatic treatment.According to the concept of ″people-oriented″,the study group further applied humanistic care as the main quality nursing intervention.The changes of psychological state before and after intervention were compared,the incidence of secondary infection,respiratory failure,pneumonia shock and other complications were counted,and the satisfaction of patients with nursing services was investigated.Results After intervention,the scores of self-rating anxiety scale (SAS) and self-rating depression scace (SDS) in the two groups were lower than those before intervention,the differences were statistically significant(P＜0.05）,and the scores of anxiety and depression in the study group were lower than those in the routine group (P＜0.05）.Complications in the study group were lower than those in the routine group，and nursing satisfaction was higher than that in the routine group，the differences were statistically significant(P＜0.05）.Conclusion The elderly patients with severe pneumonia are more serious,and the humanistic care-based quality nursing intervention is helpful to improve the psychological mood of the patients,reduce the occurrence of related complications,and the patients′ satisfaction is better.

Objective To investigate the application effect of one-day ward management in patients with gestational diabetes mellitus (GDM).Methods The clinical data of 86 patients with GDM who were treated in Dalian Maternal and Child Health Hospital,Liaoning Province from June 2017 to December 2019 was retrospectively analyzed,and they were divided into the control group (42 cases) and the observation group (44 cases) according to nursing methods.The control group was given routine nursing intervention,and the observation group was given one-day ward management intervention.The fasting blood glucose at admission,1 month after delivery and the blood glucose level 2 h after meal and self-efficacy and adverse pregnancy outcomes were compared between the two groups.Results The fasting blood glucose 1 month after delivery and the blood glucose 2 h after meal in the two groups were lower than that at admission,the differences were statistically significant (P＜0.05);the fasting blood glucose level in the two groups 1 month after delivery was compared,the difference was not statistically significant (P＞0.05).The blood glucose 2 h after meal of the observation group was lower than that of the control group,the difference was statistically significant (P＜0.05).The general self-efficacy scale (GSES) scores of the two groups 1 month after delivery were higher than those at admission,the differences were statistically significant (P＜0.05);the GSES score of the observation group was higher than that of the control group 1 month after delivery,the difference was statistically significant (P＜0.05).The total incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The one-day ward management method is used to intervene in patients with GDM,which can effectively control the patient′s postprandial blood glucose,improve the patient′s self-efficacy，and improve the adverse pregnancy outcome.It has a relatively good intervention effect and is worthy of clinical promotion.

Objective To evaluate the influence of perioperative nursing intervention on postoperative psychological state of cancer patients.Methods Sixty cancer patients who received treatment in Fuxin Second People′s Hospital,Liaoning Province from March 2019 to February 2020 were selected as research subjects.They were divided into two groups by random number table method,30 cases in each group.Patients in the control group received routine care,while in the study group,they were given comprehensive nursing intervention measures.The psychological status of patients before and after operation,the degree of pain at different times after operation,and the postoperative complications were compared between the two groups.Results There were no significant differences in the scores of the two groups on the self-rating depression scale (SDS) or the self-rating anxiety scale (SAS) at admission (P＞0.05).The scores of SDS and SAS of the study group were at 24 h before operation and 24 h after operation both lower than those of the control group,with statistical differences (P＜0.05).There was no statistical difference in visual analogue scale(VAS) score between the two groups at 12 and 72 h after operation (P＞0.05).The VAS score of the study group was lower than that of the control group at 24 and 48 h after operation,with statistical difference (P＜0.05).The total incidence of complications such as lower limb venous thrombosis in the control group was 26.67%,and 10.00% in the study group,with statistical difference after comparison (P＜0.05).Conclusion The perioperative application of comprehensive nursing interventions for gynecological cancer patients can improve their postoperative negative mood,alleviate their postoperative pain and reduce postoperative complications.

Objective To explore the application value of nursing intervention based on protective motivation theory in self-management with young and middle-aged stroke diseases.Methods A total of 80 cases with acute ischemic stroke(AIS) admitted to Shenyang First People′s Hospital,Liaoning Province from March 2019 to May 2020 were selected and divided into two groups,40 cases in each group.The control group was given routine nursing,the observation group was given nursing intervention mode based on protective motivation theory,then the bad living habits (smoking,alcoholism staying up late and high-fatdiet)after intervention and the scores of disease self-management ability between the two groups before and after intervention were compared,the length of stay and life quality at discharge were compared.Results After intervention,the percentages of unhealthy living habits such as smoking,alcoholism,staying up late and high-fat diet in the observation group were lower than those of the control group,the differences were statistically significant (P＜0.05),the scores of self-care,symptom self-treatment,drug self-treatment,psychological self-regulation and social intercourse ability in the observation group were higher than those of the control group,the differences were statistically significant (P＜0.05).The duration of hospitalization in observation group was shorter than that in the control group,the scores and total scores of quality of life at discharge were higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion The nursing intervention model based on the theory of protective motivation can better change patients′ bad living habits,improve disease self-management ability and shorten hospitalization time and improve life quality.

Objective To explore the application effect of clinical nursing pathway in the nursing of elderly asthma patients.Methods From April 2017 to December 2018,76 cases of senile asthma patients treated in Ansteel Group General Hospital,Liaoning Province were selected.They were divided into the study group (38 cases) and the control group (38 cases) using the random double-blind method.The control group was given routine nursing,the study group was given clinical nursing path intervention,the nursing effect of the two groups was compared.Results The total effective rate (94.7%),knowledge awareness rate (92.1%) and nursing total satisfaction (94.7%) in the study group were higher than those in the control group (73.7%,71.1%,68.4%),the recurrence rate (5.3%) 1 year after nursing was lower than that of the control group (28.9%),the length of stay was shorter than that of the control group,treatment cost was less than that of the control group,differences were statistically significant (P＜0.05).50% maximum expiratory flow(FRF),75% FRF,positive end-expiratory pressure (PEFP) and quality of life scores between the two groups before nursing,the differences were not statistically significant (P＞0.05).After nursing,50%FRF,75%FRF,PEFP,quality of life scores in the study group were higher than those of the control group,the differences were statistically significant(P＜0.05).Conclusion Clinical nursing pathway intervention for elderly asthma patients is helpful to improve their disease awareness and treatment effect,accelerate their recovery,and improve their quality of life.This nursing model is recognized by many patients.It is worth popularizing in clinic.

Objective To investigate the influence of continuous nursing based on WeChat platform in patients with peptic ulcer (PU).Methods A total of 200 patients with PU who were admitted to Yingkou Central Hospital,Liaoning Province from January 2017 to December 2019 were selected.All the patients were divided into two groups according to random number table method,100 cases in each group.The control group was given routine nursing,and the observation group underwent continuous nursing based on WeChat platform.The compliance behavior after discharge for 3 months,quality of life (Nottingham health profile [NHP]) before intervention and after intervention for 3 months were compared between the two groups,and the recurrence was observed.Results The total compliance rate of the observation group was 98.00%,which was higher than that of the control group (88.00%),with statistically significant difference (P＜0.05).There was no statistically significant difference in the score of NHP between the two groups before intervention (P＞0.05).The scores of NHP in the observation group were lower than those in the control group after intervention,with statistically significant differences (P＜0.05).The recurrence rate of the observation group was 1%,which was lower than 10% of the control group,with statistically significant difference (P＜0.05).Conclusion The continuous nursing based on WeChat platform can enhance the compliance behavior of patients with PU,improve the quality of life and reduce the recurrence rate.

Objective To approach influence of pulmonary function for brain damage children by external diaphragm pacemaker with respiratory rehabilitation nursing technique in convalescence period.Methods A total of 60 cases brain damage children treated in Shenyang Children′s Hospital from July 2019 to July 2020 were selected as objects of study,who were divided into the control group (30 cases) and the detection group (30 cases) by random slip method.The control group used routine inhalation rehabilitation nursing health instruction,the detection group used external diaphragm pacemaker with respiratory rehabilitation nursing technique,the pulmonary function index,suction index,daily life quality score of two group before intervention and after intervention were compared.Results The lung capacity,maximum ventilation percentage,oxygenation,oxygenation index,peak airway pressure,airway resistance,daily life quality score of two group before intervention were compared,the differences had no statistical significance (P＞0.05).After intervention,lung capacity,maximum ventilation percentage,oxygenation,oxygenation index,airway resistance,daily life quality score of the two groups were higher than those before intervention,peak airway pressure was lower than that before intervention;lung capacity,maximum ventilation percentage,oxygenation,oxygenation index,airway resistance,daily life quality score of detection group were higher than those of the control group,peak airway pressure was lower than that in the control group,the differences had statistical significance (P＜0.05).Conclusion The application of pulmonary function for brain damage children by external diaphragm pacemaker with respiratory rehabilitation nursing technique in convalescence period,which could improve pulmonary function and suction index of children,increase daily life quality of children,it is worth to be used.

Objective To explore the effect of neurorehabilitation nursing on the recovery of neurological and motor functions and quality of life in patients with stroke.Methods From August 2017 to August 2019,240 patients with stroke admitted to Guangdong Work Injury Rehabilitation Hospital were selected as the research objects,and they were divided into the research group and the control group according to random number table method,120 cases in each group.The control group used conventional rehabilitation nursing intervention,and the research group used neurorehabilitation nursing intervention.neurologic impairment scale (NDF) score and Fugl-Meyer score were used to evaluate the neurological and motor functions of patients before and after care in each group.The quality of life rating scale(GQOL-74) was used to evaluate the quality of life in two groups after care.Results There were no significant difference in NDF score and Fugl-Meyer score between the two groups of patients before nursing (P＞0.05);after nursing,the NDF score of the two groups were lower than before nursing,and the Fugl-Meyer score were higher than before nursing,the NDF score of the study group was lower than the control group,and the Fugl-Meyer score was higher than control group,the differences were statistically significant (P＜0.05);After nursing,he physical,psychological,social,and physical function scores were higher than those of the control group,with statistical differences (P＜0.05).Conclusion Nursing rehabilitation intervention can improve the neurological and motor dysfunction,and the quality of life in stroke patients,，which is worthy of clinical application.