Objective To explore the influencing factors of quality of life in patients with colorectal cancer after laparoscopic radical resection.Methods A Total of 103 patients with colorectal cancer undergoing laparoscopic radical operation in Songzi People′s Hospital from September 2017 to September 2019 were selected as the research objects.The patients were followed up for 12 months by telephone and outpatient reexamination.The quality of life was evaluated by Karnofsky Performamce Status(KPS)score.Multivariate Logistic regression analysis was used to analyze the risk factors of postoperative quality of life.Results Univariate analysis showed that there were no significant differences in KPS scores of gender,family history,TNM stage,basic diseases,preoperative carcino-embryonic antigen(CEA),preoperative carbohydrate antigen 19-9(CA19-9),depth of invasion and intraoperative blood loss(P＞0.05);KPS score of patients aged ＞60 were lower than those of patients ≤60 years old,KPS scores of patients with low differentiation were lower than those of patients with high and moderate differentiation,and KPS scores of patients with tumor diameter＞5 cm was lower those of patients with tumor diameter ＜5 cm,the KPS scores of patients with intestinal obstruction were lower than those without intestinal obstruction,and the KPS score of patients with lymph node metastasis were lower than those without lymph node metastasis(P＜0.05).Multivariate Logistic regression analysis showed that age,differentiation degree,tumor diameter,preoperative intestinal obstruction and lymph node metastasis were independent risk factors for postoperative quality of life(P＜0.05).Conclusion Age,differentiation degree,tumor diameter,preoperative intestinal obstruction and lymph node metastasis are independent risk factors for postoperative quality of life in patients with laparoscopic radical resection of colorectal cancer.