1. Clinical Laboratory, the Sixth Affiliated Hospital of Guangzhou Medical University (Qingyuan People′s Hospital),Guangdong Province, Qingyuan 511510, China;
2. Department of General Surgery, the Sixth Affiliated Hospital of Guangzhou Medical University (Qingyuan People′s Hospital), Guangdong Province, Qingyuan 511510, China
Abstract：Objective To investigate the influencing factors and pathogen in critically ill patients complicated with bloodstream infection. Methods A total of 162 patients complicated with bloodstream infections admitted to the Critical Care Department of the Sixth Affiliated Hospital of Guangzhou Medical University from January to June 2020 were selected as the observation group, and a total of 162 patients without bloodstream infection were selected as the control group. Data were collected and the influencing factors and pathogens in critically ill patients complicated with bloodstream infections were analyzed. Results The results of univariate analysis suggested that the observation group′s age,cerebrovascular disease, diabetes, central venous catheterization, mechanical ventilation period > 5 d, and the use of antibacterial drugs within 30 d before admission were statistically different from those in the control group after comparison (P<0.05). The results of multivariate analysis suggested that age ≥60 years old (β=1.606,OR=4.982,95%CI=2.862-8.671), cerebrovascular disease (β=1.203, OR=3.329, 95%CI=1.969-5.628), diabetes (β=0.774, OR=2.168, 95%CI=1.345-3.495), mechanical ventilation period > 5 d (β=1.613, OR=5.017, 95%CI=3.115-8.080), antibacterial drugs used within 30 d before admission (β=0.900, OR=2.460, 95%CI=1.461-4.143) were high-risk factors for critical ill patients complicated with bloodstream infections (P<0.05). A total of 251 pathogenic bacteria were separated from hemoculture samples of 162 patients in the observation group, including 155 Gram-negative bacteria (61.75%), 86 Gram-positive bacteria (34.27%), and 10 fungi (3.98%). Conclusion Critically ill patients complicated with bloodstream infections are related to age, mechanical ventilation period, use of antibacterial drugs, complication of cerebrovascular diseases, and diabetes. Gram-negative bacteria are the main pathogenic bacteria of critically ill patients complicated with bloodstream infections. Clinical nursing interventions should be strengthened for various risk factors to reduce the occurrence of bloodstream infections.Targeting on the pathogenic bacteria, drug susceptibility tests are carried out, and antibacterial drugs are reasonably selected according to the test results to enhance the therapeutic effect.
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