脑梗死合并睡眠呼吸暂停患者通气功能与血脂代谢、胰岛素抵抗及动脉粥样硬化程度的相关性

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摘要目的探讨脑梗死合并睡眠呼吸暂停患者通气功能与血脂代谢、胰岛素抵抗及动脉粥样硬化程度的相关性。方法收集2014年9月～2016年12月在本院接受治疗的脑梗死合并睡眠呼吸暂停患者32例作为A组，单纯脑梗死患者43例作为B组，另取同期在本院进行体检的健康人群50例作为正常对照组。检测三组的通气功能指标，血脂代谢、胰岛素抵抗指标，超声动脉粥样硬化参数。采用Pearson法评估脑梗死合并睡眠呼吸暂停患者通气功能与血脂代谢、胰岛素抵抗及动脉粥样硬化参数的相关性。结果A、B组患者的通气功能指标FEV1、FEV1/FVC 水平低于正常对照组（P＜0.05），外周血中血脂代谢指标 TC、TG、LDL－C 的含量高于正常对照组（P＜0.05），HDL－C 含量低于正常对照组（P＜0.05），外周血中 FINS、HOMA－IR 的水平高于正常对照组（P＜0.05）；超声动脉粥样硬化参数IMT、AC、PWVβ水平高于正常对照组（P＜0.05）；A组患者上述改变程度均大于B组；Pearson检验发现，A组患者通气功能水平与血脂代谢、胰岛素抵抗及动脉粥样硬化严重程度直接相关（P＜0.05）。结论脑梗死合并睡眠呼吸暂停患者存在通气功能抑制，且具体通气状态与血脂代谢、胰岛素抵抗及动脉粥样硬化等病情严重指标直接相关。

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	卢丰才

关键词 ：脑梗死, 睡眠呼吸暂停, 通气功能, 血脂代谢, 胰岛素抵抗

Abstract：

ObjectiveTo investigate the correlation etween ventilation function and blood lipid metabolism,insulin resistance,atherosclerosis degree in patients with cerebral infarction complicated with sleep apnea.Methods32 patients with cerebral infarction complicated with sleep apnea treated in our hospital from September 2014 to December 2016 were collected as group A,43 patients with simple cerebral infarction were selected as group B,and 50 healthy subjects who received：physical examination in our hospital during the same period were collected as normal control group.Ventilation function index,blood lipid metabolism index and insulin resistance index and ultrasonic atherosclerosis parameter of three groups were determined.Pearson method was used to assess the correlation between ventilation function and blood lipid metabolism,insulin resistance and atherosclerosis parameter in patients with cerebral infarction complicated by sleep apnea.ResultsVentilation function indexes FEV1and FEV1/FVC level of group A and group B were lower than those of normal control group(P＜0.05),blood lipid metabolism indexes such as TC,TG and LDL－C content in peripheral blood were higher than those of normal control group (P＜0.05),while HDL－C content were lower than those of normal control group(P＜0.05).FINS and HOMA－IR level in peripheral blood were higher than those of normal control group(P＜0.05).Ultrasonic atherosclerosis parameter such as IMT,AC and PWVβ level were higher than those in normal control group,and the above changes in group A were greater than those in group B (P＜0.05).Pearson test showed that the ventilation function level in patients with cerebral infarction complicated by sleep apnea were directly correlated with the blood lipid metabolism,insulin resistance and atherosclerosis severity.ConclusionThere are ventilation function inhibition in patients with cerebral infarction complicated by sleep apnea,and the specific state of ventilation is directly correlated with disease severity indicators such as blood lipid metabolism,insulin resistance,atherosclerosis and so on.

Key words： Cerebral infarction Sleep apnea Ventilation function Lipid metabolism Insulin resistance

引用本文:

卢丰才. 脑梗死合并睡眠呼吸暂停患者通气功能与血脂代谢、胰岛素抵抗及动脉粥样硬化程度的相关性[J]. 中国当代医药, 2017, 24(29): 36-39.
LU Feng-cai. Correlation between ventilation function and blood lipid metabolism,insulin resistance,atherosclerosis degree in patients with cerebral infarction complicated with sleep apnea. 中国当代医药, 2017, 24(29): 36-39.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2017/V24/I29/36

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