Abstract：Objective To investigate the application effect of Urapidil combined with Esmolol for controlled hypotension in patients with intracranial aneurysm interventional surgery. Methods A total of 220 patients with intracranial aneurysms admitted to our hospital from January 2017 to January 2019 were selected as the research objects, and the patients were divided into observation group (110 cases) and control group (110 cases) according to the random number table method. Patients in the observation group were given Urapidil combined with Esmolol for controlled hypotension,and patients in the control group were given Sodium Nitroprusside for controlled hypotension. The intraoperative blood pressure stability, ventilation, oxygenation scores, total amount of Isoflurane inhalation and blood pressure control were compared, and the postoperative mean arterial pressure, hemorheology, normal electrocardiogram score, normal blood pressure monitoring score and end-tidal carbon dioxide partial pressure were compared between the two groups. Results The intraoperative blood pressure stability, ventilation and oxygenation scores in the observation group were higher than those in the control group, and the total amount of Isoflurane inhalation was less than that in the control group,with statistically significant differences (P＜0.05). The postoperative mean arterial pressure, hemorheology and end-tidal carbon dioxide partial pressure in the observation group were lower than those in the control group, and the normal electrocardiogram and normal blood pressure monitoring scores were higher than those in the control group, with statistically significant differences (P＜0.05). The stability score of blood pressure in the observation group was higher than that in the control group, the fluctuation range of blood pressure was smaller than that in the control group, and the dosage of antihypertensive drugs was less than that in the control group, with statistically significant differences (P＜0.05). Conclusion Urapidil combined with Esmolol in interventional surgery for intracranial aneurysms has a good effect in controlled hypotension, and the stability of blood pressure is good, which is conducive to achieving good surgical results.
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