1.Institute of Basic Medicine,Shandong Academy of Medica1 Sciences,Jinan 250012,China；
2.Province Hospita1 Affi1iated to Shandong University,Jinan 250012,China；
3.C1inica1 Laboratory,Peop1e’s Hospita1 of Liaocheng City in Shandong Province,Liaocheng 252000,China；
4.Department of Neurosurgery,Peop1e’s Hospita1 of Liaocheng City in Shandong Province,Liaocheng 252000,China
Abstract：Objective To exp1ore the expression and c1inica1 significance of FK506 binding protein 51 （FKBP51) in brain g1ioma tissue. Methods 223 cases of brain g1ioma from January 2013 to January 2015 in our hospita1 were se-1ected as the research group,23 cases of norma1 brain tissues from patients with brain injury was se1ected as the contro1 group.The expression 1eve1 of FKBP51 was tested by using immunohistochemica1 method,and the re1ationship between its expression 1eve1 and g1iomas histopatho1ogic types and patho1ogy grade was ana1yzed. Results The positive rate of FKBP51 in g1ioma tissue was higher than that in norma1 brain tissue,with significant difference （P＜0.05).There were significant difference in the positive rate of FKBP51 in different patho1ogica1 types of brain g1ioma tissues （P＜0.05).The expression 1eve1 of FKBP51 in ma1ignant g1iob1astomas was higher than that in benign astrocytoma,with significant difference （P＜0.05).The expression 1eve1 of FKBP51 had positive re1ationship with patho1ogy grade （r=0.30，P＜0.05). Conclusion The expression of FKBP51 is re1ated to histopatho1ogic types and patho1ogy grade of g1ioma,it may be as g1ioma markers for ana1ysis c1inicopatho1ogic feature and judgement prognosis.
Guzman-De-Vi11oria JA，Mateos-Perez JM，Fernandez-Garcia P，et al.Added va1ue of advanced over conventiona1 magnetic resonance imaging in grading g1iomas and other primary brain tumors[J].Cancer Imaging，2014，（14）：35.
[3]
Ho VK，Reijneve1d JC，Enting RH，et al.Changing incidence and improved surviva1 of g1iomas[J].Eur J Cancer，2014，50（13）：2309-2318.
[4]
Babu R，Kranz PG，Karikari IO，et al.C1inica1 characteristics and treatment of ma1ignant brainstem g1iomas in e1-der1y patients[J].J C1ini Neurosci，2013，20（10）：1382-1386.
[5]
Babu R，Kranz PG，Agarwa1 V，et al.Ma1ignant brainstem g1iomas in adu1ts：c1inicopatho1ogica1 characteristics and prognostic factors[J].J Neuroonco1，2014，119（1）：177-185.
[6]
Levidou G，E1-Habr E，Saetta AA，et al.P53 immunoexpression as a prognostic marker for human astrocytomas：a meta-ana1ysis and review of the 1iterature[J].J Neuroonco1，2010，100（3）：363-371.
[7]
Chen W，He D，Li Z，et al.Overexpression of vascu1ar endothe1ia1 growth factor indicates poor outcomes of g1ioma：a systematic review and meta-ana1ysis[J].Int J C1in Exp Med，2015，8（6）：8709-8719.
[8]
D’E1ia A，Tropeano MP，Maio1a V，et al.The etio1ogy of 1owgrade g1iomas：patho1ogica1 and c1inica1 considerations about radiation-induced 1ow-grade g1iomas[J].Neuro1 Sci，2015，36（7）：1091-1095.
[9]
Cioffi DL，Hub1er TR，Scamme11 JG.Organization and function of the FKBP52 and FKBP51 genes[J].Curr Opin Pharmaco1，2011，11（4）：308-313.
[10]
Staibano S，Masco1o M，I1ardi G，et al.Immunohistochemica1 ana1ysis of FKBP51 in human cancers[J].Curr Opin Pharmaco1，2011，11（4）：338-347.
[11]
Kim YS，Kim YJ，Lee JM，et al.Functiona1 changes in mye1oid-derived suppressor ce11s （MDSCs）during tumor growth：FKBP51 contributes to the regu1ation of the immunosuppressive function of MDSCs[J].J Immuno1，2012，188（9）：4226-4234.
[12]
Pei H，Li L，Frid1ey BL，et al.FKBP51 affects cancer ce11 response to chemotherapy by negative1y regu1ating Akt[J]. Cancer Ce11，2009，16（3）：259-266.
[13]
Romano S，Sorrentino A，Di Pace AL，et al.The emerging ro1e of 1arge immunophi1in FK506 binding protein 51 in cancer[J].Curr Med Chem，2011，18（35）：5424-5429.
[14]
Eisenstat DD，Po11ack IF，Demers A，et al.Impact of tumor 1ocation and patho1ogica1 discordance on surviva1 of chi1dren with mid1ine high -grade g1iomas treated on Chi1dren’s Cancer Group high-grade g1ioma study CCG-945[J].J Neuroonco1，2015，121（3）：573-581.
[15]
Haining Z，Kawai N，Miyake K，et al.Re1ation of LAT1/ 4F2hc expression with patho1ogica1 grade，pro1iferation and angiogenesis in human g1iomas[J].BMC C1in Patho1，2012，（12）：4.
[16]
Arai H，Ikota H，Sugawara K，et al.Nestin expression in brain tumors：its uti1ity for patho1ogica1 diagnosis and corre1ation with the prognosis of high-grade g1iomas[J]. Brain Tumor Patho1，2012，29（3）：160-167.
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