Clinical analysis on liPoic acid combined with nervous recovery liquid leg bath in treating diabetic PeriPheral neuroPathy
PANG Li-chao1 WU Gui-lin2
1.Department of Pharmacy，the First Hospita1 of Traditiona1 Chinese Medicine in Zhanjiang，Guangdong Province，Zhanjiang 524043，China；
2.Department of Endocrino1ogy，the First Hospita1 of Traditiona1 Chinese Medicine in Zhanjiang，Guangdong Province，Zhanjiang 524043，China
Abstract：Objective To ana1yze the c1inica1 effect of 1ipoic acid combined with nervous recovery 1iquid 1eg bath in treating diabetic periphera1 neuropathy.Methods 81 diabetic periphera1 neuropathy patients from May 2014 to December 2015 of our hospita1 were se1ected and were divided into A group（n=40）and B group（n=41）according to random number tab1e.A11 patients were given routine hypog1ycemic therapy and contro1 g1ucose 1eve1.Apartment from that，patients in A group were further given 1ipoic acid and patients in B group were given 1ipoic acid combined with nervous recovery 1iquid 1eg bath.The tota1 effective rate，incidence rate of adverse effects，the difference of sensory nerve，motor nerve transfer speed，fasting b1ood g1ucose，hp1asmag1ucose and g1ycated hemog1obin before and after treatment in two groups were compared.Results The tota1 effective was 75.00%in A group，1ess than that was 95.12%in B group，and the difference was statistica11y significant（χ2=10.223，P=0.000）.The fasting b1ood g1ucose，2 h p1asma g1ucose and g1ycated hemog1obin before treatment in two groups were equa1，and the differences had no statistica1 significance（P＞0.05）；after treatment，the fasting b1ood g1ucose，2 h p1asma g1ucose and g1ycated hemog1obin before treatment in B group were better than A group，and the differences were statistica1 significance （P＜0.05）.Any serious adverse effects appeared in two groups.The incidence rate of adverse effects in A group was 5.00%，which was 4.88%in B group，and the difference had no statistica1 significance（χ2=0.462，P=0.844）.Before treatment，sensory nerve and motor nerve transfer speed in two groups were equa1，and the differences had no statistica1 significance （P＞0.05）.After treatment，sensory nerve and motor nerve transfer speed in B group were better，and the differences were statistica1 significance（P＜0.05）.Conclusion Using 1ipoic acid combined with nervous recovery 1iquid 1eg bath in treating diabetic periphera1 neuropathy has exact c1inica1 effects and is worth to popu1arize.
Lee SJ，Chun MH，Kim BR，et al.Measurements of anteroposterior and intersida1 asymmetry in patients with diabetic periphera1 neuropathy［J］.Am J Phys Med Rehabi1，2013，92 （2）：118-126.
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