Effect of continuous intraoperative pumping of Dexmedetomidine on cognitive function in elderly patients undergoing laparoscopic surgery
WEI Jiang-fu1 ZHANG Ai-min2 CHEN Li-ni2▲
1.Department of Anesthesiology,Liugang Hospital of Guangxi Zhuang Autonomous Region,Liuzhou 545002,China;
2.Department of Anesthesiology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China
Abstract：ObjectiveTo investigate the effect of intraoperative continuous infusion of Dexmedetomidine on cognitive dysfunction in elderly patients after laparoscopic surgery.Methods44 patients with laparoscopic radical gastrectomy underwent elective general anesthesia from January 2015 to June 2016 were randomly divided into Dexmedetomidine group and normal saline group.The loading dose of Dexmedetomidine was maintained at 0.8 μg/(kg·h)for 15 min before anesthesia induction,followed by 0.4 μg/(kg·h)of sedation during surgery and 40 min before the end of surgery in the Dex group.Ns group was given intravenous infusion of equal volume of saline.MAP,HR and SpO2value were recorded before tracheal intubation(T0),intubation(T1),at the beginning of surgery(T2),at 30 min(T3),10 min before extubation (T4),30 min after extubation(T5).The operation time,spontaneous breathing recovery time,extubation time and sober time were recorded.At 1 days(D0),after 1 day operation(D1),and postoperative day three(D2),the number of adverse reactions such as nausea,vomiting and dizziness were recorded.ResultsAt the T1,T2,T4and T5time points,MAP and HR(exception of T1)of Dex group were significantly lower than those of Ns group(P＜0.05).At the time of D1-D2,compared with Ns group, the incidence of POCD in Dex group was significantly lower than that in Ns group (P＜0.05).There was no significant difference in the incidence rate of nausea and vomiting,vertigo between the two groups(P＞0.05).ConclusionIntraoperative pumping of Dexmedetomidine during operation is conducive to intraoperative circulatory stability,reduce the use of anesthetic drugs,reduce the incidence of postoperative POCD,and does not increase the awakening time and adverse reactions in the intraoperative continuous injection of Dexmedetomidine.
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