Abstract：Objective To explore the application effect of evidence-based nursing in sequential mechanical ventilation therapy. Methods A total of 150 critically ill patients admitted to the Second Affiliated Hospital of Nanchang University from February 2019 to February 2020 were selected as the research subjects. They were divided into the routine group(75 cases)and the observation group(75 cases)by grasping the ball.Routine nursing was used in the routine group,and evidence-based nursing was applied in the observation group. The blood gas indicators including blood oxygen saturation, blood oxygen partial pressure, blood carbon dioxide partial pressure, ventilation time, hospital stay, and adverse events including ventilator-associated pneumonia (VAP), unplanned extubation, medical disputes, and complaints were compared between the two groups. Results Before the intervention, there were no statistically significant difference in blood gas indicators between the two groups(P＞0.05).After the intervention,the blood oxygen saturation and partial pressure of oxygen in the observation group were higher than those in the control group, and the partial pressure of carbon dioxide in the observation group was lower than the control group, with statistical differences (P<0.05). The mechanical ventilation time and hospital stay in the observation group were shorter than those in the control group, and the differences were statistically significant (P<0.05). The incidence of VAP, unplanned extubation, medical disputes, and complaints in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion Evidence-based nursing can improve the blood oxygen saturation of patients treated by sequential mechanical ventilation, increase the partial pressure of blood oxygen, reduce the partial pressure of carbon dioxide, shorten the time of mechanical ventilation and hospital stay, and reduce the incidence of VAP and other adverse events.
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