Abstract：Objective To investigate the clinical effect of Shensong Yangxin Capsules combined with Metoprolol in the treatment of premature ventricular contractions in coronary heart disease. Methods A total of 60 patients with premature ventricular beats of coronary heart disease admitted to the Department of Cardiology，Heilongjiang College of Traditional Chinese Medicine From December 2019 to April 2021 were selected as the research subjects，and were divided into control group (30 cases) and treatment group (30 cases) according to random number table method. The control group was treated with conventional western medicine combined with Metoprolol，and the treatment group was treated with Shensong Yangxin Capsules on the basis of the control group. Traditional Chinese medicine (TCM)syndrome score，plasma N-terminal B-type natriuretic peptide (NT-proBNP)，angiotensin Ⅱ(Ang Ⅱ)，number of 24 h premature pulse and cardiac function indexes (left ventricular end systolic diameter [LVESD]，left ventricular end diastolic diameter [LVEDD]，left ventricular ejection fraction [LVEF]) were compared between the two groups. Results There was no significant difference in TCM syndrome score between the two groups before treatment (P＞0.05). After treatment，TCM syndrome scores of both groups were lower than before，and the treatment group was lower than the control group，the difference was statistically significant (P＜0.05). There was no significant difference in the levels of NT-proBNP and Ang Ⅱbetween two groups before treatment (P＞0.05). After treatment，the serum levels of NTproBNP and Ang Ⅱin both groups were lower than before，and the treatment group was lower than the control group，the differences were statistically significant (P＜0.05). There was no significant difference in the number of premature pulse 24 h before treatment between the two groups (P＞0.05). After treatment，the number of 24 h premature pulse in both groups was less than before，and the number of 24 h premature pulse in the treatment group was less than the control group，the difference was statistically significant (P ＜0.05). There was no significant difference in cardiac function indexes between the two groups before treatment (P＞0.05). After treatment，LVESD and LVEDD in the two groups were lower than before，and LVEF was higher than before，and LVESD and LVEDD in the treatment group were lower than the control group，and LVEF was higher than the control group，the differences were statistically significant(P＜0.05). Conclusion Shensong Yangxin Capsules combined with Metoprolol has obvious effect in the treatment of ventricular premature beat of coronary heart disease，which can improve the clinical symptoms of traditional Chinese medicine，improve NT proBNP and Ang Ⅱindexes，reduce the number of premature beats and improve cardiac function，which is worthy of promotion.
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