Objective To evaluate the medication burden of patients with severe mental disorders who participated in medication subsidy in a district of Shenzhen,and to provide guidelines for patients′ assistance.Methods Through the hospital information management system,relevant data of medication subsidy of 7 hospitals in a district of Shenzhen from 2016 to 2020 were retrospectively collected,the times of patients picking up medicine,the price of commonly used antipsychotic medicine,the rate of "zero out-of-pocket" and the level of outpatient expenses were calculated.The linear regression was used to analyze the relationship among medication price,policy adjustments and "zero out-ofpocket" rate.Results A total of 4006 patients with 81 589 times of medication subsidies were included in the analysis,including 601 registered patients whose median level of prescribing medicine was 24 times/person,and 3405 non-registered patients whose median level of prescribing medicine was 15 times/person,there was statistically significant difference in the number of times of prescribing medicine between registered patients and non-registered patients for medication subsidy(P＜0.01).The rate of "zero out-of-pocket" of both registered and non-registered patients showed an increasing trend(P＜0.01).The total outpatient expenses per time and the amounts of subsidies per time for both registered and non-registered patients were negatively correlated with time(P＜0.01);the self-payment per time for non-registered patients was negatively correlated with time(P＜0.01).The linear regression equations of medication price and "zero out-of-pocket" rate of registered and nonregistered resident patients were respectively Yregistered=-0.006X+109.020(R2=0.93), Ynon-registered=-0.004X+90.221(R2=0.89).Conclusion There still exists clinic visit irregularities among patients with medication subsidy.30% patients need to pay part of their own expenses to prescribe medicine at clinics.It is thus necessary to further reduce the medication burden of patients and promote their regular medical treatment.