冠心病合并糖尿病患者血清同型半胱氨酸、尿酸水平及与冠状动脉病变严重程度的相关性分析

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摘要目的探讨冠心病合并糖尿病患者血清同型半胱氨酸（Hcy）和尿酸水平的变化情况及其与冠状动脉病变严重程度的相关性。方法选取2018年8月至2020年10月遵义市播州区人民医院心血管内科的137 例冠心病合并糖尿病患者为观察组，依据冠状动脉狭窄程度（Gensini 法）评分将观察组分为低危组（n=42）、中危组（n=59）、高危组（n=36）。选择同期的30 例糖尿病患者为对照组。比较对照组和观察组的血清Hcy 和尿酸水平，记录低危组、中危组和高危组的血清Hcy 和尿酸水平；采用Pearson 相关性分析对血清Hcy 和尿酸与Gensini 评分的相关性进行分析。结果观察组的血清Hcy 和尿酸水平高于对照组，差异有统计学意义（P＜0.05）；三组患者的Hcy 和尿酸水平比较，差异有统计学意义（P＜0.05）；低危组和中危组的Hcy 水平比较，差异无统计学意义（P＞0.05）。高危组的Hcy 水平高于低危组和中危组，中高危组患者的尿酸水平高于低危组，高危组的尿酸水平高于中危组，差异有统计学意义（P＜0.05）。血清Hcy 和尿酸与Gensini 评分均呈正相关（r=0.786、0.429，P＜0.001）。结论冠心病合并糖尿病患者的血清Hcy 和尿酸水平升高，血清Hcy 和尿酸水平与冠状动脉病变程度呈正相关。

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	谷尚武
	冯红
	陈瑶
	曾迪
	何小莉
	张兴伟

关键词 ：冠心病, 糖尿病, 同型半胱氨酸, 尿酸, Gensini 评分

Abstract：Objective To explore the changes of serum homocysteine(Hcy)and uric acid levels in patients with coronary heart disease and diabetes mellitus,and their correlation with the severity of coronary artery disease.Methods A total of 137 patients with coronary heart disease and diabetes mellitus who were enrolled in the Department of Cardiovascular Medicine of People′s Hospital of Bozhou District in Zunyi City from June 2018 to October 2020 were included in the observation group.The observation group was divided into the low risk group(n=42),the medium-sange group(n=59),the high-risk group(n=36).30 patients with diabetic mellitus in the same period were selected as the control group.The levels of serum Hcy and uric acid in the control group and the observation group were compared,and the levels of serum Hcy and uric acid in the low-risk group,the medium-risk group and the high-risk group were recorded.Pearson correlation analysis was used to analyze the correlation between serum Hcy,uric acid and Gensini score.Results The levels of serum Hcy and uric acid in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).There were significant difference in the levels of Hcy and uric acid among the three groups(P<0.05).There was no significant difference in the level of Hcy between the low-risk group and the middle-risk group(P>0.05).The Hcy level of the high-risk group was higher than that of the low-risk group and the middle-risk group,the uric acid level of the middle-risk group and high-risk group were higher than that of the low-risk group,the uric acid level of the high-risk group was higher than that of the middle-risk group,the differences were statistically significant(P<0.05).Serum Hcy and uric acid were positively correlated with Gensini score(r=0.786,0.429, P<0.001).Conclusion The levels of serum Hcy and uric acid in patients with coronary heart disease and diabetes mellitus increase,and the levels of serum Hcy and uric acid are positively correlated with the degree of coronary artery disease.

Key words： Coronary heart disease Diabetes mellitus Homocysteine Uric acid Gensini score

基金资助:贵州省遵义市科技计划项目[遵市科合HZ 字（2019）250 号]。

引用本文:

谷尚武；冯红；陈瑶；曾迪；何小莉；张兴伟. 冠心病合并糖尿病患者血清同型半胱氨酸、尿酸水平及与冠状动脉病变严重程度的相关性分析[J]. 中国当代医药, 2021, 28(27): 61-64.
GU Shang-wu；FENG Hong；CHEN Yao；ZENG Di；HE Xiao-li；ZHANG Xing-wei. Correlation analysis of serum homocysteine,uric acid levels and severity degree of coronary artery disease in patients with coronary heart disease and diabetes mellitus. 中国当代医药, 2021, 28(27): 61-64.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2021/V28/I27/61

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