Meta-analysis of traditional Chinese herbal medicine decoction combined with lifestyle interventions in the treatment of impaired glucose regulation
LI Ting-ting1 ZHANG Hong1▲ LI Wei
1. Department of Science and Education, Fangshan Hospital Beijing University of Traditional Chinese Medicine, Beijing 102400, China;
2. Department of Pulmonary Disease, Fangshan Hospital Beijing University of Traditional Chinese Medicine, Beijing 102400, China
Abstract：Objective To assess curative effects and the safety of traditional Chinese herbal medicine decoction combined with lifestyle interventions for impaired glucose regulation (IGR).Methods The Chinese and English databases were searched, and the search time limit was from January 1, 2016 to August 21, 2020. Randomized controlled trials of traditional Chinese medicine compound decoction combined with lifestyle intervention in the treatment of IGR were collected. After screening, data extraction, risk of bias and quality assessment, RevMan 5.3 was used for meta-analysis.Results A total of 8 RCTs including 666 patients were included. Meta-analysis showed that fasting blood glucose(FBG) [MD=-0.68, 95%CI (-0.94, -0.43), P<0.000 01], 2 h postprandial blood glucose (2 h PBG) [MD=-0.87, 95%CI(-1.15, -0.58), P<0.000 01], glycosylated hemoglobin (HbA1c) [MD=-0.42, 95%CI (-0.62, -0.22), P<0.0001], fasting insulin (FINS) [MD=-1.85, 95%CI (-2.64, -1.06), P<0.000 01], total cholesterol (TC) [MD=-0.75, 95%CI (-1.09, -0.41), P<0.0001], triglyceride (TG) [MD=-0.78, 95%CI (-1.08, -0.48), P<0.000 01], body mass index (BMI) [MD=-1.71, 95%CI(-2.49, -0.94), P<0.0001] in experimental group were lower than control group. Only one study reported adverse reactions. Conclusion Based on the current clinical evidence, traditional Chinese herbal medicine decoction combined with lifestyle interventions for IGR might be superior in reducing the level of FBG、2 h PBG、HbA1c、FINS、TC and TG than only lifestyle interventions. However, due to the low quality of literature and publication bias, high-quality clinical researches are still needed.
李婷婷;张红; 李伟. 中药复方汤剂联合生活方式干预治疗糖调节受损的meta分析[J]. 中国当代医药, 2021, 28(21): 13-18.
LI Ting-ting; ZHANG Hong;LI Wei. Meta-analysis of traditional Chinese herbal medicine decoction combined with lifestyle interventions in the treatment of impaired glucose regulation. 中国当代医药, 2021, 28(21): 13-18.
Isohwg W.Definition, diagnosis and classification of diabetes mellitus and its complications:report of a World Health Organisation Collaborations[J].Diabet Med，1999，15（7）：539-553.
Moin T，Schmittdiel JA，Flory JH，et al.Review of metformin use for type 2 diabetes prevention[J].Am J Prev Med，2018，55（4）：565-574.
[24]
Hostalek U，Gwilt M，Hildemann S.Therapeutic Use of Metformin in Impaired Glucose Regulation and Diabetes Prevention[J].Drugs，2015，75（10）：1071-1094.
[25]
Hanefeld M，Pistrosch F，Koehler C，et al.Conversion of IGT to type 2 diabetes mellitus is associated with incident cases of hypertension：a post-hoc analysis of the STOPNIDDM trial[J].J Hypertens，2012，30（7）：1440-1443.
International Diabetes Federation.Diabetes Atlas reports 463 million with diabetes[DB/OL].https://www.idf.org/news/169:diabetes-atlas-reports-463-million-with-diabetes.html，2019.
[2]
Li G，Zhang P，Wang J，et al.The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Preventions Study：a 20-year follow-up study[J].Lancet，2008，371（9626）：1783-1789.
[3]
Knowler WC，Fowler SE，Hamman RF，et al.10-year followup of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study[J].Lancet，2009，374（9702）：1677-1686.
[4]
Jia WP，Pang C，Chen L，et al.Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population：the Shanghai Diabetes Studies，a cross-sectional 3-year follow-up study in Shanghai urban communities[J].Diabetologia，2007，50（2）：286-292.
Lindstrom J，Ilanne-Parikka P，Peltonen M，et al.Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention：follow-up of the Finnish Diabetes Prevention Study[J].Lancet，2006，368（9548）：1673-1679.
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