Abstract：Objective To analyze the information marked in the instructions of commonly used psychotropic drugs and objectively understand the adverse drug reactions (ADR)，so as to provide reference for promoting the rational clinical use of drugs. Methods A total of 92 commonly used instructions of oral psychotropic drugs at home and abroad collected from psychiatric specialty hospitals and over second-level general hospitals in our city were classified and reviewed，and various common ADR，medication and pharmacokinetic parameters of special population were analyzed synthetically. Results The ADR of common psychotropic drugs involved many organs or systems and was serious. There were many vague words like ＂following doctor′s advice or reducing or having not been determined or studied＂ in the medication of pregnant women，lactation，children and the elderly. Most psychotropic drugs had active metabolites，long drug half-life (T1/2) and high plasma protein binding rate，some drugs，such as selective serotonin reuptake inhibitors (SSRIs)had strong inhibition on P450. Conclusion Physicians，pharmacists，patients and their family members should work out individualized drug delivery plans in combination with the patients′ own physical and mental conditions，carefully combine medications，and improve the compliance of patients with drugs.
陈育煌； 余巧； 安中原； 殷蕾. 精神类药物临床合理用药及常见不良反应探究[J]. 中国当代医药, 2020, 27(18): 170-173.
CHEN Yu-huang； YU Qiao； AN Zhong-yuan； YIN Lei. Study on the rational use of psychotropic drugs and common adverse reactions. 中国当代医药, 2020, 27(18): 170-173.
京公网安备 11010502046607号