Abstract:Objective To investigate the correlation between the ratio of triglyceride (TG) to high density lipoprotein cholesterol (HDL-C) and patients with type 2 diabetes complicated with osteoporosis. Methods A total of 186 hospitalized patients with type 2 diabetes in our hospital from April 2018 to April 2019 were selected as subjects. According to the differences in bone mineral density of lumbar spine and proximal end of left femur detected by dual energy x-ray absorptiometry, the patients were divided into normal bone mass group (64 cases), osteopenia group (77 cases) and osteoporosis group(45 cases).Venous blood was collected from patients in the three groups,and fasting blood glucose(FBG),uric acid (UA), TG, total cholesterol (TC), HDL-C, low-density lipoprotein cholesterol (LDL-C), cystatin C (CysC), and serum glycosylated hemoglobin (HbA1c) were detected. The correlation between the ratio of TG/HDL-C and bone mineral density was analyzed by One-way analysis of variance and Pearson correlation. Results The body mass index(BMI), UA, TG and TG/HDL-C of the osteoporosis group were lower than those of the osteopenia group and the normal bone mass group, and the differences were statistically significant (P<0.05). The duration of diabetes in the osteoporosis group was longer than that in the osteopenia group and the normal bone mass group, HDL-C, LDL-C and CysC were higher than those in the osteopenia group and the normal bone mass group, and the differences were statistically significant (P<0.05). BMI, UA, TG and TG/HDL-C in the osteopenia group were lower than those in the normal bone mass group, with statistically significant differences (P<0.05). The duration of diabetes in the osteopenia group was longer than that in the normal bone mass group, and HDL-C, LDL-C and CysC were higher than those in the normal bone mass group,with statistically significant differences(P<0.05).Pearson correlation analysis results showed that TG/HDL-C was positively correlated with bone mineral density of lumbar L1-4, left femoral neck, femoral trochanter, wards triangle and all femur in patients with type 2 diabetes (r=0.275, 0.281, 0.276, 0.268, 0.287, P<0.001). Conclusion Low TG/HDL-C is related to the increased risk of type 2 diabetes complicated with osteoporosis.
何圣清; 郑晓斌; 武红梅. 三酰甘油/高密度脂蛋白胆固醇比值与2型糖尿病患者合并骨质疏松的相关性[J]. 中国当代医药, 2020, 27(16): 113-116.
HE Sheng-qing; ZHENG Xiao-bing; WU Hong-mei. Correlation between the ratio of triglyceride to high density lipoprotein cholesterol and patients with type 2 diabetes complicated with osteoporosis. 中国当代医药, 2020, 27(16): 113-116.
Jiang N,Xia W.Assessment of bone quality in patients with diabetes mellitus[J].Osteoporos Int,2018,29(8):1721-1736.
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