Abstract:In recent years,environmental pollution and haze weather are increasing with the development of industry and the acceleration of urbanization in China.There are more and more inhalable particles in the atmosphere,and the inhalable particles whose aerodynamic diameter is less than or equal to 2.5 μm (PM2.5) do great harm to human body.The increase of PM2.5 in the environment is positively correlated with the increase of the number of patients with respiratory diseases.PM2.5 has the characteristics of small particle size and large specific surface area.It is easy to carry polycyclic aromatic hydrocarbons and other harmful substances and pathogens.If these substances and bacteria are inhaled into the respiratory tract,they can deposit in the bronchi to promote the release of inflammatory factors and destroy the micro ecological balance of the lung,leading to the occurrence or aggravation of a variety of respiratory system diseases such as pneumonia,bronchial asthma,pulmonary fibrosis,lung cancer and chronic obstructive pulmonary disease.Although some studies have showed the relationship of PM2.5 and respiratory diseases,the research foundation is still relatively weak.This paper reviews the effect of PM2.5 on respiratory diseases and the related mechanisms,so as to provide reference for further research.
孙静; 张勉. PM2.5对呼吸系统损伤的研究进展[J]. 中国当代医药, 2020, 27(14): 26-29.
SUN Jing ; ZHANG Mian. Research progress of PM2.5 on respiratory system injury. 中国当代医药, 2020, 27(14): 26-29.
Jin C,Shelburne CP,Li G,et al.Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation[J].J Clin Invest,2011,121(3):941-955.
[2]
Kumar P,Ram U.Patterns factors associated and morbidity burden of asthma in India[J].PLoS One,2017,12(10):e0185938.
[3]
Barnes PJ.Immunology of asthma and chronic obstructive pulmonary disease[J].Nat Rev Immunol,2008,8(3):183-192.
[4]
Ogino K,Zhang R,Takahashi H,et al.Allergic airway inflammation by nasal inoculation of particulate matter(PM2.5)in NC/Nga mice[J].PLoS One,2014,9(3):e92710.
[5]
Dobreva ZG,Kostadinova GS,Popov BN,et al.Proinflammatory and anti-inflammatory cytokines in adolescents from Southeast Bulgarian cities with different levels of air pollution[J].Toxicol Ind Health,2015,31(12):1210-2017.
[6]
He M,Ichinose T,Yoshida S,et al.PM2.5 induced lung inflammation in mice;differences of inflammatory response in macrophages and type Ⅱalveolar cells[J].J Appl Toxicol,2017,37(10):1203-1218.
[7]
Avalos A,Haza AI,Mateo D,et al.Effects of silver and gold nanoparticles of different sizes in human pulmonary fibroblasts[J].Toxicol Mech Methods,2015,25(4):1-9.
Zhao C,Liao J,Chu W,et al.Involvement of TLR2 and TLR4 and Th1/Th2 shift in inflammatory responses induced by fine ambient particulate matter in mice[J].Inhal Toxicol,2012,24(13):918-927.
Adeloye D,Chua S,Lee C,et al.Global and regional estimates of COPD prevalence:Systematic review and metaanalysis[J].J Glob Health,2015,5(2):20 415.
[16]
Pinault L,Tjepkema M,Crouse DL,et al.Risk estimates of mortality attributed to low concentrations of ambient fine particulate matter in the Canadian community health survey cohort[J].Environ Health,2016,15(1):18.
[17]
Li T,Hu R,Chen Z,et al.Fine particulate matter PM2.5:the culprit for chronic lung diseases in China[J].Chronic Dis Transl Med,2018,4(3):176-186.
[18]
Lawal AO.Air particulate matter induced oxidative stress and inflammation in cardiovascular disease and atherosclerosis:The role of Nrf2 and AhR-mediated pathways[J].Toxicol Lett,2017,270(15):88-95.
[19]
Cabrera-Fuentes HA,Lopez ML,Mccurdy S,et al.Regulation of monocyte/macrophage polarisation by extracellular RNA[J].Thromb Haemost,2015,114(3):473-481.
[20]
Liu CW,Lee TL,Chen YC,et al.PM2.5-induced oxidative stress increases intercellular adhesion molecule-1 expression in lung epithelial cells through the IL-6/AKT/STAT3/NF-κB-dependent pathway[J].Part Fibre Toxicol,2018,15(1):4.
[21]
Wang J,Huang J,Wang L,et al.Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-κB signaling pathway[J].J Thorac Dis,2017,9(11):4398-4412.
[22]
Gao W,Li L,Wang Y,et al.Bronchial epithelial cells:the key effector cells in the pathogenesis of chronic obstructive pulmonary disease[J].Respirology,2015,20(5):722-729.
[23]
Barnes PJ.Inflammatory mechanisms in patients with chronic obstructive pulmonary disease[J].J Allergy Clin Immunol,2016,138(1):16-27.
Gu XY,Chu X,Zeng XL,et al.Effects of PM2.5 exposure on the Notch signaling pathway and immune imbalance in chronic obstructive pulmonary disease[J].Environ Pollut,2017,226(7):163-173.
Amsen D,Helbig C,Backer RA.Notch in T Cell differentiation:all things considered[J].Trends Immunol,2015,36(12):802-814.
[28]
Rycroft CE,Heyes A,Lanza L,et al.Epidemiology of chronic obstructive pulmonary disease:a literature review[J].Int J Chron Obstruct Pulmon Dis,2012,7(20):457-494.
[29]
Atkinson RW,Anderson HR,Sunyer J,et al.Acute effects of particulate air pollution on respiratory admissions:results from APHEA2 project[J].Am J Respir Crit Care Med,2001,164(10 Pt 1):1860-1866.
[30]
Molyneaux PL,Cox MJ,Wells AU,et al.Changes in the respiratory microbiome during acute exacerbations of idiopathic pulmonary fibrosis[J].Respir Res,2017,18(1):29.