Study on the relationship between atmospheric pollutants and male sperm quality in Shenyang
LIANG Yue1,2 YAN Xin-xin3 ZHANG Jin-zhe1,2 MA Hui-ping4 GUO Ting-chao1,2 ZHANG Qiang3▲
1.National Health Commission Key Laboratory of Reproductive Health and Medical Genetics,China Medical University,Liaoning Province,Shenyang 110031,China;
2.Liaoning Research Institute of Family Planning,Liaoning Province,Shenyang 110031,China;
3.Department of Occupational and Environmental Health,School of Public Health,Tianjin Medical University,Tianjin 300070,China;
4.Reproductive Medicine Center,Shenyang Women′s and Children′s Hospital,Liaoning Province,Shenyang 110011,China
Abstract：Objective To study the relationship between the exposure of different atmospheric pollutants in four stages of sperm development and the decline of sperm quality of the man in Shenyang.Methods A randomized survey was conducted on 216 men patients from Liaoning Research Institute of Family Planning who underwent at least one semen examination from September 23 to December 16,2016.According to the semen parameter reference limits of WHO Semen Examination and Processing Laboratory Manual,the study subjects were divided into normal group and decreased group among parameters.The data were strictly screened,statistical methods was used to organize entries and establish databases.Independent-sample t-test,rank sum test,and binary Logistic regression analysis were used to evaluate the relationship between atmospheric pollutants from 0-90 days before semen examination,0-9 days before semen examination,10-14 days before semen examination ,70-90 days before semen examination and sperm motility,forward motile sperm,sperm concentration and sperm count.Results At 0-90 days and 70-90 days before semen collection,CO exposure concentration had a significant effect on sperm concentration and total sperm count,and the difference between normal group and decreased group was statistically significant (P<0.10).At 10-14 days before semen collection,NO2and O3exposure concentration had a significant effect on sperm concentration,and the difference between normal group and decreased group was statistically significant (P<0.10).The concentration of O3exposure had a significant effect on the total number of sperm,and the difference between the normal group and the decreased group was statistically significant (P<0.10).There were no statistically significant differences between the normal group and the decreasing group in the semen parameters of other atmospheric pollutants (P>0.10).Conclusion The exposure of atmospheric pollutants CO,NO2and O3during sperm development have adverse effect on sperm concentration and total sperm count,and O3exposure concentration is a risk factor for decreased sperm concentration.
梁悦； 严鑫鑫； 张金哲； 马会平； 郭廷超； 张强. 沈阳市大气污染与男性精液质量的关系研究[J]. 中国当代医药, 2020, 27(2): 178-182.
LIANG Yue； YAN Xin-xin； ZHANG Jin-zhe； MA Hui-ping； GUO Ting-chao； ZHANG Qiang. Study on the relationship between atmospheric pollutants and male sperm quality in Shenyang. 中国当代医药, 2020, 27(2): 178-182.
Hansen C，Luben TJ，Sacks JD，et al.The effect of ambient air pollution on sperm quality[J].Environ Health Perspect，2010，118（2）：203-209.
[2]
Hammoud A，Carrell DT，Gibson M，et al.Decreased sperm motility is associated with air pollution in Salt Lake City[J].Fertil Steril，2010，93（6）：1875-1879.
[3]
Cao XN，Yan C，Liu DY，et al.Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol 3-kinase（PI3K)/protein kinase B（Akt）signaling pathway[J].Toxicol Lett，2015，237（3）：181-190.
[4]
Lafuente R，Blàzquez NG，Jacquemin B，et al.Outdoor air pollution and sperm quality[J].Fertil Steril，2016，106（4）：880-896.
[5]
Trasande L，Malecha P，Attina TM.Particulate matter exposure and preterm birth：estimates of U.S.attributable burden and economic costs[J].Environ Health Perspect，2016，124（12）：1913-1918.
[6]
Meng Z，Bai W.Oxidation damage of sulfur dioxide on testicles of mice[J].Environ Res，2004，96（3）：298-304.
[7]
Pires A，de Melo EN，Mauad T，et al.Pre- and postnatal exposure to ambient levels of urban particulate matter（PM2.5）affects mice spermatogenesis[J].Inhal Toxicol，2011，23（4）：237.
[8]
Boggia B，Carbone U，Farinaro E，et al.Effects of working posture and exposure to traffic pollutants on sperm quality[J].J Endocrinol Invest，2009，32（5）：430-434.
[12]
Wu L，Jin L，Shi T，et al.Association between ambient particulate matter exposure and semen quality in Wuhan，China[J].Environ Int，2017，98：219-228.
[15]
Zhou N，Cui Z，Yang S，et al.Air pollution and decreased semen quality：a comparative study of Chongqing urban and rural areas[J].Environ Pollut，2014，187：145-152.
[16]
Santi D，Vezzani S，Granata AR，et al.Sperm quality and environment：A retrospective，cohort study in a Northern province of Italy[J].Environ Res，2016，150：144-153.
[9]
Dejmek J，Jelínek R，Solansky′ I，et al.Fecundability and parental exposure to ambient sulfur dioxide[J].Environ Health Perspect，2000，108（7）：647-654.
[10]
Radwan M，Jurewicz J，Polańska K，et al.Exposure to ambient air pollution-does it affect semen quality and the level of reproductive hormones？[J].Ann Hum Biol，2015，43（1）：50-56.
[11]
Lao XQ，Zhang Z，Lau AKH，et al.Exposure to ambient fine particulate matter and semen quality in Taiwan[J].Occup Environ Med，2018，75（2）：148-154.
[13]
Ma WL，Qi H，Li YF，et al.Seasonal and spatial variations of air concentrations of polycyclic aromatic hydrocarbons in Northeastern Chinese urban region[J].Bull Environ Contam Toxicol，2011，86（1）：43-49.
[14]
Pant N，Shukla M，Kumar Patel D，et al.Correlation of phthalate exposures with semen quality[J].Toxicol Appl Pharmacol，2008，231（1）：112-116.
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