Comparison effect of Alogliptin and Acarbose in the treatment of newly diagnosed type 2 diabetes mellitus and their effects on gastrointestinal related hormones
XU Rong XIA Wen-yan GUO LiZENG Shu-qin LYU Wei-ming▲
Department of Endocrine,the First Affiliated Hospital of Gannan Medical College,Jiangxi Province,Ganzhou 341000,China
Abstract:Objective To investigate the clinical effects of Alogliptin and Acarbose on newly diagnosed type 2 diabetes mellitus(7%<HbA1c<8.5%)and their effects on gastrointestinal hormones.Methods Sixty newly diagnosed type 2 diabetes mellitus patients in the Department of endocrinology of our hospital from January 2017 to January 2018 were selected,they were divided into treatment group and control group according to random number table method,with 30 cases in each group.The patients in the treatment group were treated with Alogliptin and the patients in the control group were treated with Acarbose for 24 weeks.Blood sugar,HbA1c and body mass index(BMI)were compared between the two groups before and after treatment,changes of gastrointestinal hormones and occurrence of adverse reactions.Results The levels of fasting blood glucose(FPG),postprandial 2-hour blood glucose(2-hour PG)and HbA1c in the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).BMI level of the two groups after treatment was lower than that before treatment,but there was no significant difference(P>0.05).There was no significant difference in FPG,2 h PG and HbA1c between the two groups(P>0.05).Gastrin and gastrin levels in the treatment group after treatment were lower than those before treatment on fasting and 2 hours after meal(P<0.05).In the control group after treatment,the level of ghrelin in fasting and 2 hours after meal was lower than that before treatment,and the level of ghrelin in fasting and 2 hours after meal was higher than that before treatment,but there was no significant difference(P>0.05).The levels of ghrelin and gastrin in the treat-ment group after treatment were lower than those in the control group on fasting and 2 hours after meal(P<0.05).There were no severe gastrointestinal adverse reactions and severe hypoglycemia in both groups.Conclusion Both Alogliptin and Acarbose significantly improved blood sugar in newly diagnosed type 2 diabetes mellitus(7%<HbA1c<8.5%),however,the effect of agritin on reducing fasting and postprandial gastrin is more significant,and it can be used as an effective clinical treatment for type 2 diabetes mellitus.
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XU Rong;XIA Wen-yan;GUO Li;ZENG Shu-qin;LYU Wei-ming▲. Comparison effect of Alogliptin and Acarbose in the treatment of newly diagnosed type 2 diabetes mellitus and their effects on gastrointestinal related hormones. 中国当代医药, 2019, 26(5): 61-63.
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