Abstract:ObjectiveTo investigate the effect of Simvastatin combined with Alendronate sodium on bone healing in elderly patients with hip fracture internal fixation.MethodsForty-six patients with hip fracture and internal fixation who were treated in our hospital from May 2014 to February 2017 were divided into three groups according to the random number method,15 cases in each group.The treatment group was treated with Simvastatin combined with Alendronate sodium,the control group was treated with Alendronate sodium,the blank group was treated with conventional Vitamin D and Calcium Carbonate D3tablets.The healing of hip fractures and the levels of serum bone alkaline phosphatase(BAP)and osteocalcin(BGP)were measured at four time intervals.ResultsThe healing rate of callus at 12 weeks,6 months and 12 months after operation was statistically significant compared with the first week after operation (P<0.05).The healing rate of callus at 12 weeks,6 months after operation in the treatment group was higher than that in the control group and the blank group(P<0.05).The difference of the callus healing rate between the three groups after 12 months was not statistically significant(P>0.05).Compared with preoperative,the levels of BAP were significantly increased in the first week after operation,but the levels of BGP were decreased,but there was no significant difference between the both two groups(P>0.05).After 12 weeks and 6 months,the levels of BAP and BGP in the treatment group were significantly higher than those in the control group and the blank group (P<0.05),There was no significant difference in BAP and BGP between the control group and the blank group(P>0.05).ConclusionSimvastatin combined with Alendronate sodium can be used as an effective option,and anti-osteoporosis treatment is effective,which is conducive to improving bone mass.
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