Abstract：Anti-neutrophil cytoplasmic antibodies(ANCA)-associated vasculitides (AAV)are systemic autoimmune diseases characterised by inflammation of small blood vessels.The pathogenesis of AAV is complex and remains incompletely understood.Recent advances have been made in the understanding of the pathogenesis of these diseases,including the pathogenic role of ANCA,neutrophil extracellular traps(NETs)and neutrophils as mediators of injury,dysregulation of the complement system,and the role of T cells.The aim of this review is to summarise current information and recent advances in understanding the pathogenesis of AAV.
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