前列地尔对重症急性胰腺炎患者早期促炎因子的影响及疗效分析

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摘要目的探讨前列地尔对重症急性胰腺炎患者早期促炎因子的影响及其疗效。方法选取2016年9月～2017年12月我院收治的66例重症急性胰腺炎患者作为研究对象，按照双盲法将其分为对照组（33例）与观察组（33例）。对照组患者采取氯化钠或葡萄糖溶液治疗，观察组患者予以前列地尔治疗。比较两组患者的凝血功能指标、炎症因子指标、症状改善情况。结果两组患者治疗前的血小板分布宽度（PDW）、平均血小板体积（MPV）水平比较，差异无统计学意义（P>0.05）；两组患者治疗后的PDW、MPV水平均低于治疗前，差异有统计学意义（P<0.05）；观察组患者治疗后的 PDW[（12.21±1.05）%]、MPV[（8.15±0.64）fl]水平均低于对照组[（15.54±1.31）%、（10.28±0.36）fl]，差异有统计学意义（P<0.05）。两组患者治疗前的白介素-1β（IL-1β）、白介素-6（IL-6）、肿瘤坏死因子（TNF-α）水平比较，差异无统计学意义（P>0.05）；两组患者治疗后的IL-1β、IL-6、TNF-α水平均低于治疗前，差异有统计学意义（P<0.05）；观察组患者治疗后的 IL-1β[（32.63±7.4）ng/L]、IL-6[（61.05±11.94）ng/L]、TNF-α[（62.26±17.18）ng/L]水平均低于对照组[（75.59±11.05），（76.69±10.28），（78.58±12.05）ng/L]，差异有统计学意义（P<0.05）。观察组患者的血淀粉酶恢复正常时间[（4.10±1.25）d]、肠功能恢复时间[（3.18±1.04）d]及腹痛症状缓解时间[（3.15±1.19）d]均短于对照组[（6.65±1.28），（5.37±1.23），（5.01±1.12）d]，差异有统计学意义（P<0.05）。结论应用前列地尔治疗重症急性胰腺炎，能够减轻患者的炎症反应程度，促进各症状早日消失，效果可靠。

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	永雪薇
	张莉

关键词 ：前列地尔, 重症, 急性胰腺炎, 早期促炎因子, 疗效

Abstract：Objective To investigate the effect and efficacy of Alprostadil on early proinflammatory factors in patients with severe acute pancreatitis.Methods Sixty-six patients with severe acute pancreatitis who were admitted to our hospital from September 2016 to December 2017 were selected as the study subjects.They were divided into the control group (33 cases)and the observation group (33 cases)according to a double-blind method.The control group was treated with sodium chloride or glucose solution,and the observation group was given Alprostadil.The coagulation function,inflammatory factors,and symptom improvement were compared between two groups.Results There were no significant differences in the levels of platelet distribution width(PDW)and Mean platelet volume(MPV)before treatment between two groups(P>0.05).The levels of PDW and MPV in two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The levels of PDW and MPV after treatment in the observation group([12.21±1.05]%,[8.15±0.64]fl)were lower than those in the control group([15.54±1.31]%,[10.28±0.36]fl),and the differences were statistically significant(P<0.05).There were no significant differences in the levels of IL-1β,IL-6,TNF-α before treatment between two groups(P>0.05).The levels of IL-1β,IL-6,TNF-α in two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The levels of IL-1β ([32.63±7.4]ng/L),IL-6([61.05±11.94]ng/L),TNF-α ([62.26±17.18]ng/L)after treatment in the observation group were lower than those in the control group([75.59±11.05],[76.69±10.28],[78.58±12.05]ng/L),and the differences were statistically significant(P<0.05).The recovery time of blood amylase ([4.10±1.25]d),intestinal function ([3.18±1.04]d)and the relief time of abdominal pain ([3.15±1.19]d)in the observation group were shorter than those in the control group （[6.65±1.28],[5.37±1.23],[5.01±1.12]d）,and the differences were statistically significant(P<0.05).Conclusion In the treatment of severe acute pancreatitis,the application of Alprostadil can reduce the degree of inflammatory reaction in patients and promote the early disappearance of various symptoms,with reliable effect.

Key words： Alprostadil Severe Acute pancreatitis Early proinflammatory cytokines Efficacy

引用本文:

永雪薇;张莉. 前列地尔对重症急性胰腺炎患者早期促炎因子的影响及疗效分析[J]. 中国当代医药, 2018, 25(24): 130-132.
YONGXue-wei;ZHANGLi. Effect and efficacy analysis of Alprostadil on early proinflammatory cytokines in patients with severe acute pancreatitis. 中国当代医药, 2018, 25(24): 130-132.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2018/V25/I24/130

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