Abstract：Objective To investigate the clinical efficacy of S-adenosylmethionine （SAM）combined with ursodeoxycholic acid in the treatment of intrahepatic cholestasis during pregnancy （ICP）.Methods A total of 64 patients with ICP from May 2015 to May 2017 in our hospital were selected as study subjects.Random number table method was used to divide them into control group and study group,32 cases in each group.Both groups were given routine symptomatic treatment.In the control group,ursodeoxycholic acid was added,while in the study group,SAM combined with ursodeoxycholic acid was added.The clinical efficacy and maternal and infant outcomes were compared between the two groups.Results The scores of pruritus symptoms and related indexes of liver function after treatment in both groups were significantly lower than those before treatment(P＜0.05）.The scores of pruritus symptoms and related indexes of liver function after treatment in the study group were significantly lower compared with those in the control group with statistical significance (P＜0.05）.In the study group,the incidence of cesarean section,neonatal asphyxia,postpartum hemorrhage,fetal distress and preterm birth were significantly lower than those in the control group with statistical significance (P＜0.05）.Conclusion The combination of SAM and ursodeoxycholic acid in the treatment of ICP can obtain a definite effect.It can significantly improve the symptoms of pruritus,liver function indicators and maternal and fetal outcomes.
李娜. S-腺苷蛋氨酸联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症的临床效果[J]. 中国当代医药, 2018, 25(25): 115-117.
LI Na. Clinical effect of S-adenosylmethionine combined with ursodeoxycholic acid in the treatment of intrahepatic cholestasis during pregnancy. 中国当代医药, 2018, 25(25): 115-117.
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