Abstract：ObjectiveTo analyze the clinical effect of quadruple therapy in treatment of Clarithromycin resistant Helicobacter pylori infection.Methods Sixty patients with Helicobacter pylori infection admitted to Nan′ao People′s Hospital in Dapeng New District,Shenzhen City from February 2014 to February 2017 were selected and divided into control group and study group,by random number table method with 30 cases in each group.The control group was treated with Metronidazole,Omeprazole and Amoxicillin triple therapy,while the study group was treated with Omeprazole,Bismuth Potassium Citrate Granules,Amoxicillin and Levofloxacin triple therapy.The eradication rate of Helicobacter pylori and the total incidence of adverse reactions were compared between the two groups.Results The eradication rate of Helicobacter pylori in the study group was 93.33%（28/30）,higher than 80%（24/30） in the control group,the difference was statistically significant(χ2=7.6876,P=0.0056).There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion In the clinical treatment of Helicobacter pylori infection,Omeprazole,Amoxicillin,Bismuth Potassium Citrate Granules and Levofloxacin are recommended to be the first choice for quadruple therapy,which can improve the eradication rate of helicobacter pylori and is worth further promotion.
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