Abstract：Objective To observe the clinical effect of Olanzapine in improving mental and behavioral disorder in patients with senile dementia.Methods A total of 114 patients with senile dementia accompanied with mental and behavioral disorder treated by the Fourth People′s Hospital of Jingdezhen from January 2016 to October 2017 were selected and they were divided into the control group and observation group,and there were 57 cases in each group.The control group was treated with Risperidone,while the observation group was treated with Olanzapine.After 8 weeks of continuous drug use,the clinical effect between the two groups was compared.Results The total effective rate of the observation group was 92.98%,while that of the control group was 89.47%,and there was no significant difference between the two groups(P＞0.05).At 2,4 and 8 weeks after treatment,the BEHAVE-AD score of the patients in the observation group was(18.0±4.4),(10.1±3.8)and (7.0±3.3)points respectively,which were lower than those of the control group ([20.2±4.5],[13.7±4.0],[8.6±3.8]points)and before treatment([23.2±5.2])points,and the differences were statistically significant(P＜0.05).In patients of the control group,the BEHAVE-AD score at 2,4 and 8 weeks after treatment were all lower than those before treatment([22.9±5.0])points,and the differences were statistically significant(P＜0.05).The incidence of abnormal liver function,lethargy and fatigue after treatment in the observation group was 1.75%,8.77%and 7.02%respectively,and the control groups was 0.00,7.02%and 3.51%respectively,and there was no significant difference between the two groups(P＞0.05).The incidence of irritation,extrapyramidal reaction and insomnia in the observation group was 0.00,3.51%,1.75%respectively,which were lower than those of the control group(8.77%and 19.30%.14.04%)(P＜0.05),and the total incidence of side effect in the observation group was 22.81%,which was lower than that of the control group(52.63%),and the difference was statistically significant(P＜0.05).The ADL score of the observation group after treatment was(37.1±7.0)points,which was lower than that of the control group([40.7±8.5]points),and the difference was statistically significant(P＜0.05).Conclusion Olanzapine treating senile dementia accompanied with mental and behavioral disorder can effectively improve the pathological behavior of patients with Alzheimer disease,with significant clinical effect,fewer side effects and high safety.It is worthy of clinical promotion.
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