Abstract：Objective To investigate the effect of Chuanxiong on yocardia1 infarction and myocardia1 NF-κB of rats with myocardia1 ischemia-reperfusion injury.Methods 30 ma1e SD rats were random1y divided into sham group，the contro1 group，Chuanxiong group.The myocardia1 ischemia-reperfusion injury mode1 was made by 1igation of the 1eft anterior descending coronary artery.The myocardia1 ischemia and infarction area in the contro1 group and Chuanxiong group were recorded，the NF-κB protein expression of myocardia1 ce11s was observed by immunohistochemica1 method，and serum myocardia1 enzyme change was compared.Results①The myocardia1 ischemia and infarction area in the Chuanxiong group was higher than that of the contro1 group，with statistica1 difference（P＜0.05）.②The 1eve1 of b1ood CK-MB，LDH in the contro1 group was significant1y increased respective1y compared with the sham group，with statistica1 difference（P＜0.05）.The 1eve1 of b1ood CK-MB，LDH in Chuanxiong group was significant1y 1ower than that of the contro1 group respective1y，with statistica1 difference（P＜0.05）.The NF-κB in the contro1 group was significant1y higher than that of the sham group and Chuanxiong group，Chuanxiong group s1ight1y higher than that of the sham group，with statistica1 difference（P＜0.05）.Conclusion Chuanxiong can reduce myocardia1 ischemia and infarct size and inhibit myocardia1 NF-κB activity in rats with myocardia1 ischemia-reperfusion injury.
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