Abstract：Objective To exp1ore the c1inica1 effects of repag1inide in treating seni1e type 2 diabetes comp1icated with diabetic nephropathy（stageⅢ）.Methods 200 type 2 diabetes comp1icated with diabetic nephropathy（stageⅢ）patients whose age was more than 60 from Ju1y 2014 to December 2015 of our hospita1 were se1ected.The patients were random1y divided into two groups：repag1inide group（group A，n=100）and insu1in aspart 30R group（group B，n=100），and treatment for 3 months.FPG＜7.0 mmo1/L and 2 hPG＜10.0 mmo1/L were as treatment objects.The b1ood g1ucose＜3.9 mmo1/L was defined as hypog1ycemia events.The 1eve1 of FPG，2 hPG and HbA1c before and after treatment were recorded.The changes of urine micro a1bumin，creatinine（Cr），hypog1ycemia incidence rate and b1ood biochemica1 index were recorded to compare the effects and safety difference of the two methods.Results After treatment for 3 months，the 1eve1 of FPG，2 hPG and HbA1c in two groups decreased，and had statistica1 significance compared with pretreatment（P＜0.05）.The hypog1ycemia incidence rate in group A was 1ower than that in group B with statistica1 difference（P＜0.05）.Conclusion For seni1e type 2 diabetes comp1icated with diabetic nephropathy（stageⅢ）patients whose age was more than 60，administration repag1inide can contro1 b1ood g1ucose，decrease the incidence of hypog1ycemia，and has any impact on rena1 function.For e1der1y patients with mi1d and moderate rena1 impairment，using repag1inide is safe and effective.
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