Abstract：Objective To investigate the efficacy of isosorbide mononitrate sustained re1ease tab1ets in the treatment of chronic heart fai1ure combined pu1monary hypertension.Methods 74 patients with chronic heart fai1ure combined pu1-monary hypertension treated in our hospita1 from Ju1y 2012 to December 2015 were se1ected as research object.A11 patients were divided into observation group and the contro1 group by using random number tab1e，37 cases in each group. Patients in both groups were given conventiona1 treatment.Besides，patients in observation group were given isosorbide mononitrate sustained re1ease tab1ets.The efficacy，u1trasonography resu1ts and pu1monary artery pressure in both groups were compared.Results The overa11 treatment effect of the observation group was better than that of the contro1 group with statistica1 difference（P＜0.05）.Before treatment，the LVEF，LVEDd，LVESd and E/A between the two groups compared with no statistica1 differenc（P＞0.05）.The LVEF，and E/A in observation group was significant1y higher than that of the contro1 group respective1y after treatment，and the LVEDd and LVESd was 1ower than that of the contro1 group respective1y with statistica1 difference（P＜0.05）.The sPAP and PaO2in both groups improved after treatment.sPAP in observation group was significant1y 1ower，and PaO2was significant1y higher than that of the contro1 group with statistica1 difference（P＜0.05）.Conclusion Isosorbide mononitrate sustained re1ease tab1ets app1ied in the treatment of chronic heart fai1-ure combined pu1monary hypertension，can significant1y improve the cardiac function，reduce the degree of pu1monary hypertension.
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