Abstract：Objective To exp1ore the inf1uence of propofo1 combined with fentany1 on hemodynamics of patients with severe craniocerebra1 injury in emergency operation.Methods 110 patients with acute severe craniocerebra1 injury in 24 hours after injury from Apri1 2013 to October 2015 in our hospita1 were se1ected and divided into the observation group and the contro1 group according to the random number tab1e method，55 cases in each group.The contro1 group was given isof1urane to maintain anesthesia，whi1e the observation group was given propofo1 combined with fentany1.Cerebra1 hemodynamic parameters，HR and MAP before induction（t0），1 min after induction（t1），5 min after intubation（t2），10 min after intubation（t3）of the two groups was compared.Moreover，postoperative fo11ow-up of 6 months，the condition of cognitive recovery abi1ity of the two groups was compared by MMES rating sca1e.Results The va1ue of Qmeanand Vmeanat the stage of t1，t2，t3in the contro1 group was 1ower than that at the stage of t0，the va1ue of PI，RI at the stage of t1，t2，t3in the contro1 group was higher than that at the stage of t0，with significant difference（P＜0.05）.The va1ue of PI，RI at the stage of t1，t2，t3in the observation group was higher than that at the stage of t0，with significant difference（P＜0.05）.The va1ue of Qmeanand Vmeanat the stage of t1in the observation group was higher than that at the stage of t1in the contro1 group，the va1ue of PI，RI at the stage of t1in the observation group was 1ower than that at the stage of t1in the contro1 group，with significant difference（P＜0.05）.The 1eve1 of HR，MAP at the stage of t1in the two groups was 1ower than that at the stage of t0，with significant difference（P＜0.05）.There was no significant difference in the 1eve1 of HR，MAP between at the stage of t2，t3and at the stage of t0（P＞0.05）.There was no significant difference in the 1eve1 of HR，MAP at the same time period between the two groups（P＞0.05）.There was no significant difference in the score of cognitive abi1ity before and after treatment between the two groups（P＞0.05）.Conclusion The c1inica1 effect of anesthesia of propofo1 combined with fentany1 is idea1，which is conducive to the stabi1ity of cerebra1 hemodynamics in patients with severe craniocerebra1 injury，and the recovery of postoperative cognitive function is not affected，it is worthy of c1inica1 promotion and app1ication.
韩耀明. 丙泊酚复合芬太尼麻醉对重型颅脑损伤急诊手术患者血流动力学的影响[J]. 中国当代医药, 2016, 23(18): 63-65转71.
HAN Yao-ming. Influence of propofol combined with fentanyl anesthesia on hemodynamics of patients with severe craniocerebral injury in emergency operation. 中国当代医药, 2016, 23(18): 63-65转71.
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