Research progress of m TOR signal pathway effect in ischem ic heart disease
YANG Zi-jian1 QIN Fu-zhong1,2▲
1.Department of Vasculocadiology,the First Clinical Medical College of Shanxi Medical University,Taiyuan 030001, China;
2.Department of the Cardiovascular Disease Hospital of ShanxiMedical University,Taiyuan 030001,China
Abstract：The increase in themorbidity and mortality of ischemic heart disease（IHD）is a serious threat to the health ofmankind.Mammalian target of rapamycin(mTOR)is a kind of conservative serine/threonine protein kinase,which can regulate the cell size,cell growth,protein synthesis,cytoskeleton,nutrition and energy transfer.Research have shown that mTOR plays a key regulating role in the occur and process of ischemic heart disease.This articlemainly discuss the role of mTOR in ischemia-reperfusion,myocardial infarction myocardial remodeling and ischemic heart failure. Furthermore，combining with the development of the mTOR inhibitors-rapamycinto to explore its clinical application prospect.
杨资鉴;秦富忠. m TOR信号通路在缺血性心脏病中的研究进展[J]. 中国当代医药, 2016, 23(33): 16-19.
YANG Zi-jian;QIN Fu-zhong. Research progress of m TOR signal pathway effect in ischem ic heart disease. 中国当代医药, 2016, 23(33): 16-19.
H He，N Li，Z Zhao，et al.Ischemic postconditioning improves the expression of cellular membrane connexin 43 and attenuates the reperfusion injury in rat acute myocardial infarction[J].Biomed Rep，2015，3（5）：668-674.
[2]
Balasubramanian S，Johnston RK，Moschella PC，et al.mTORin growth and protec tion of hypertrophying myocardium[J]. Cardiovasc Hematol Agents Med Chem，2009，7（1）：52-63.
[3]
Hwang SK，Kim HH.The functions of mTOR in ischemic diseases[J].BMB Rep，2011，44（8）：506-511.
[4]
Chong ZZ.mTOR：a novel therapeutic target for diseases of multiple systems[J].Curr Drug Targets，2015，16（10）：1107-1132.
[5]
Xia Z，Li H，Irwin MG.Myocardial ischaemia reperfusion injury：the challengeoftranslating ischaemic and anaesthetic protectionfrom animal models to humans[J].B J Anaesth，2016，117（S2）：ii44-ii62.
[6]
Matsui Y，Takagi H，Qu X，et al.Distinct roles of autophagy inthe heart during ischemia and reperfusion：roles of AMP-activated proteinkinase and Beclin 1 in mediating autophagy[J].Circ Res，2007，100（6）：914-922.
[7]
Sciarretta S，Hariharan N，Monden Y，et al.Is autophagy in response to ischemia and reperfusion protective ordetrimental for the heart?[J].Pediatr Cardiol，2011，32（3）：275-281.
[8]
Zoncu R，Bar-Peled L，Efeyan A，et al.mTORC1 senses lysosomal amino acids through an insideoutmechanism that requires the vacuolar H-ATPase[J].Science，2011，334（6056）：678-683.
[9]
Zhai P，Sciarretta S，Galeotti J，et al.Differential roles of GSK-3β during myocardial ischemia and ischemia/ reperfusion[J].Circ Res，2011，109（5）：502-511.
[10]
Aoyagi T，Kusakari Y，Xiao CY，et al.CardiacmTOR protects the heart against ischemia-reperfusion injury[J]. AmJPhysiol Heart Circ Physiol，2012，303（1）：H75-85.
[11]
Zhou Y，Fang H，Lin S，et al.Qili qiangxin protects against cardiac ischemia-reperfusion injury via activation of the mTOR pathway[J].Cell Physiol Biochem，2015，37（2）：454-464.
[12]
Li X，Zhang J，Huang J，et al.A Multicenter randomized double-blind parallel-group placebo-controlled study of the effects of qili qiangxin capsules in patients with chronic heart failure[J].JAm Coll Cardiol，2013，62（12）：1065-1072.
[13]
Buss SJ，Muenz S，Riffel JH，et al.Beneficial effects of mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction[J].J Am Coll Cardiol，2009，54（25）：2435-2446.
[14]
Laplante M，Sabatini DM.Regulation of mtorc1 and its impact on gene expression at a glance[J].JCell Sci，2013，126（Pt8）：1713-1719.
[15]
Johnson SC，Rabinovitch PS，Kaeberlein M.Mtor is a key modulator of ageing and age-related disease[J].Nature，2013，493（7432）：338-345.
Sciarretta S，Zhai P，Shao D，et al.Rheb is a critical regulator of autophagy during myocardial ischemia：pathophysiological implications in obesity and metabolic syndrome[J].Circulation，2012，125（9）：1134-1146.
[18]
Kerr BA，Ma L，West XZ，et al.Interference with akt signaling protects againstmyocardial infarction and death by limiting the consequences of oxidative stress[J].Sci Signal，2013，6（287）：1834-1840.
[19]
McLean BA，Kienesberger PC，Wang W，et al.Enhanced recovery from ischemia-reperfusion injury in pi3κzαominant negative hearts：investigating the role of alternate pi3K isoforms，increased glucose oxidation and MAPK signaling[J].JMol Cell Cardiol，2013，54：9-18.
[20]
Dhingra R，Gang H，Wang Y，et al.Bidirectional regulation of nuclear factor-кB and mammalian target of rapamycin signaling functionally links Bnip3 gene repression and cell survival of ventricularmyocytes[J].Circ Heart Fail，2013，6 （2）：335-343.
[21]
Volkers M，Konstandin MH，Doroudgar S，et al.Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage[J].Circulation，2013，128（19）：2132-2144.
[22]
Mathew J，SleightP，Lonn E，etal.Reduction ofcardiovascular risk by regression of electrocardiographic markers of left ventricular hypertrophy by the angiotensin-converting enzyme inhibitor ramipril[J].Circulation，2001，104（14）：1615-1621.
Chen H，Wang X，Tong M，et al.Intermedin suppresses pressure overload cardiac hypertrophy through activation of autophagy[J].PLoSOne，2013，8（5）：e64757.
[25]
Soesanto W，Lin HY，Hu E，et al.Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats[J].Hypertension，2009，54 （6）：1321-1327.
[26]
Bishu K，OgutO，Kushwaha S，et al.Anti-remodeling effects of rapamycin in experimental heart failure：dose response and interaction with angiotensin receptor blockade[J].PLoS One，2013，8（12）：e81325.
[27]
Li MH，Zhang YJ，Yu YH，et al.Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy[J].Eur J Pharmacol，2014，728：67-76.
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