Clinical efficacy of Valsartan combined with Hydrochlorothiazide in the treatment of senile hypertension and its influence on blood pressure variability
LI Jing
General Department,People′s Hospital of Zhongshan City in Guangdong Province,Zhongshan528403,China
摘要目的探讨缬沙坦联合氢氯噻嗪治疗老年高血压的临床效果及对血压变异性的影响。方法选择我院2015年3月~2016年3月治疗的90例老年高血压患者作为研究对象,依据入院先后顺序分为观察组与对照组,各45例。对照组给予缬沙坦治疗,观察组在对照组的基础上采用氢氯噻嗪治疗。分析两组的临床疗效及血压变异性。结果观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组治疗后的24 h DBPV及24 h SBPV检测结果优于对照组,差异有统计学意义(P<0.05)。观察组治疗后的24 h SBP及24 h DBP水平优于对照组,差异有统计学意义(P<0.05)。结论对临床老年高血压患者应用缬沙坦与氢氯噻嗪联合治疗效果确切,有助于提升患者血压控制效果,降低血压变异度,临床普及及进一步推广价值高。
Abstract:Objective To investigate the clinical efficacy of Valsartan combined with Hydrochlorothiazide in the treatment of senile hypertension and its influence on blood pressure variability(BPV).Methods 90 patients with senile hypertension who treated in our hospital from March 2015 to March 2016 were selected and divided into the observation group and the control group by admission order,45 cases in each group.The control group was treated with Valsartan,the observation group was treated with Hydrochlorothiazide on the basis of the control group.The clinical efficacy and BPV of the two groups were analyzed.Results The total effective rate of the observation group was higher than that of the control group,with significant difference(P<0.05).The detection results of 24 h diastolic blood pressure variability(24 h DBPV)and 24 h systolic blood pressure variability(24 h SBPV)after treatment in the observation group was better than that in the control group,with significant difference(P<0.05).The level of 24 h SBP and 24 h DBP after treatment in the observation group was better than that in the control group,with significant difference(P<0.05).Conclusion Valsartan combined with Hydrochlorothiazide in the treatment of senile hypertension have definite curative effects,it can increase blood pressure control,decrease BPV and have higher application value.
李静. 缬沙坦联合氢氯噻嗪治疗老年高血压的临床效果及对血压变异性的影响[J]. 中国当代医药, 2017, 24(10): 53-55.
LI Jing. Clinical efficacy of Valsartan combined with Hydrochlorothiazide in the treatment of senile hypertension and its influence on blood pressure variability. 中国当代医药, 2017, 24(10): 53-55.