Abstract：ObjectiveTo investigate the characteristics of hematological adverse reactions caused by linezolid and analyze the safety of drug.MethodsClinical data of 220 patients hospitalized in our hospital from January 2015 to January 2016 were retrospectively reviewed.220 patients were treated with Linezolid during hospitalization.The adverse reactions of patients with Linezolid were observed,the adverse reactions of blood system and the drug withdrawal were analyzed,and the relationship between the incidence of adverse reactions and the duration of medication was explored.ResultsIn 220 patients,adverse reactions occurred in 72 patients,and it resulted in discontinuation of the drug in 13 patients;there were no adverse reactions in 148 patients.The incidence of adverse reactionof Linezolid was higher in men than in women.Elderly patients over the age of 70 tended to suffer from Linezolid adverse reactions.The clinical manifestation of the patients with blood adverse reaction was the inhibition of blood system,the obvious decrease of platelets,the obvious decrease of hemoglobin and the obvious decrease of neutrophils,and the inhibition of blood system was the main clinical manifestation of blood adverse reaction.The longer the treatment time,the higher the incidence of adverse reactions.ConclusionLinezolid treatment can cause hematological adverse reactions in clinic,medical personnel should pay attention in the treatment of patients in treatment and nursingof them.For patients with adverse reaction,medical staff should be the right remedy to ensure that patients get an effective and safe treatment.
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