Application effect of Tirofiban in acute cerebral infarction undergoing mechanical thrombectomy
WEN Wei-wei1 ZHANG Zhi-cheng2
1. Department of Neurology, the Fifth People′s Hospital of Shenyang City, Liaoning Province, Shenyang 110000, China;
2. Department of General Surgery, the Second Affiliated Hospital of Shenyang Medical College, Liaoning Province,Shenyang 110000, China
Abstract：Objective To explore the application effects of Tirofiban in acute cerebral infarction undergoing mechanical thrombectomy. Methods From February 2016 to February 2019, a total of 88 patients with acute cerebral infarction undergoing mechanical thrombectomy admitted in the Fifth People′s Hospital of Shenyang City were selected as research objects. According to the method of the table of random number, they were divided into the control group (45 cases) and the treatment group (45 cases). In the control group, Aspirin and Clopidogrel were used, while in the treatment group,Tirofiban bridged Aspirin and Clopidogrel was used. The score of National Institutes of Health Stroke scale (NIHSS),the score of Barthel index, and the total effective rate before and after treatment were compared between the two groups. Results The NIHSS score of the treatment group after treatment was lower than that of the control group, while the Barthel index score of the treatment group was higher than that of the control group, and the differences were statistically significant (P＜0.05). The total effective rate in the treatment group was higher than that in the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞0.05). Conclusion Antiplatelet therapy of Tirofiban in emergency mechanical thrombectomy maybe a safe and effective method, which is worthy of further clinical application.
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