Abstract：Objective To observe the effect of sequential radiochemotherapy and radiochemotherapy in elderly patients with locally advanced non-small cell lung cancer.Methods From July 2020 to March 2021, 80 elderly patients with locally advanced non-small cell lung cancer in the Affiliated Hospital of Jiangnan University were used as the research objects.They were divided into observation group and control group by computer random number method, with 40 cases in each group.patient.The observation group were treated with concurrent chemotherapy and radiotherapy, and the control group were treated with sequential chemotherapy and radiotherapy.The clinical treatment effect, physiological function Karnofsky (KPS) score, the Mos item short form health survey (SF-36) score, and the total incidence of adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).There were no significant differences in the KPS score and SF-36 score of the two groups before treatment (P>0.05);the KPS score and SF-36 score of the two groups after treatment were higher than those before treatment, and the KPS score and SF-36 score of the observation group after treatment were higher than those of the control group, and the differences were statistically significant (P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion For elderly patients with locally advanced non-small cell lung cancer, concurrent radiotherapy and chemotherapy are more effective in enhancing the efficacy and improving the quality of life of patients, and the program is worth recommending.
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