糖化血清白蛋白对糖尿病诊断价值的meta分析

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摘要目的采用meta分析探讨糖化血清白蛋白对糖尿病诊断的价值。方法计算机检索2020年12月30日前发表并收录于PubMed、Cochrane Library、万方、维普、中国知网等数据库中的有关糖化血清白蛋白诊断糖尿病价值的文献。采用诊断性试验准确性质量评价工具QUADAS-2评价纳入文献的质量，应用meta-disc 1.4和Stata 15.1软件行综合定量评价。结果共纳入18篇文献。meta分析结果显示，糖化血清白蛋白对糖尿病诊断的合并敏感度（SE）=0.73，95%CI=0.71～0.74；合并特异度（SP）=0.89，95%CI=0.88～0.89；合并诊断优势比（DOR）=30.52，95%CI=18.31～50.87；SROC曲线下面积（AUCSROC）=0.8366，SEAUC=0.0522。按人群、人种、诊断标准分成 3个亚组后分析，医院人群组的合并SE、合并SP、合并DOR、合并阳性似然比（PLR）、AUCSROC均高于社区人群组，合并阴性似然比（NLR）低于社区人群组；黄种人组的合并SE、合并SP、合并 DOR、合并PLR、AUCSROC均高于非黄种人组，合并NLR低于非黄种人组；葡萄糖耐量试验（OGTT）组的合并SP、合并PLR、合并NLR高于非OGTT组，合并SE、合并DOR、AUCSROC低于非OGTT组。结论糖化血清白蛋白诊断糖尿病的敏感性尚可，特异性较高，诊断准确性较高。

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	罗金花
	何来鹏
	袁满

关键词 ：糖尿病, 糖化血清白蛋白, 诊断, meta分析

Abstract：Objective To evaluate the diagnostic value of glycated serum albumin in diabetes mellitus by meta-analysis.Methods Databases including PubMed,Cochrane Library,Wanfang,VIP,CNKI were retrieved by computer,and the literatures about the diagnostic value of glycated serum albumin for diabetes mellitus published before December 30,2020 were screened out.Diagnostic test accuracy quality assessment tool QUADAS-2 was used to evaluate the quality of the included literature,meta-disc 1.4 and Stata 15.1 software lines were used for comprehensive quantitative evaluation.Results A total of 18 articles were included.Meta-analysis showed that the combined sensitivity(SE)of glycated serum albumin in the diagnosis of diabetes mellitus was 0.73,95%CI=0.71-0.74;combined specificity (SP)was 0.89,95%CI=0.88-0.89;combined diagnostic odds ratio(DOR)was 30.52,95%CI=18.31-50.87;area under the SROC curve(AUCSROC)was 0.8366,SEAUC=0.0522.They were divided into three subgroups according to population,race and diagnostic criteria.The combined SE,combined SP,combined DOR,combined positive likelihood ratio(PLR),AUCSROCin hospital group were higher than those in community group,while the combined negative likelihood ratio (NLR)was lower than that in community group.The combined SE,combined SP,combined DOR,combined PLR and AUCSROCof the yellow race group were higher than those of the non-yellow race group,while the combined NLR was lower than that of the non-yellow race group.The combined SP,combined PLR,combined NLR in the oral glucose tolerance test(OGTT)group were higher than those in the non-OGTT group,combined SE,combined DOR and AUCSROCwere lower than non-OGTT group.Conclusion The sensitivity of glycated serum albumin in diagnosing diabetes mellitus is fair,with high specificity and high diagnostic accuracy.

Key words： Diabetes mellitus Glycated serum albumin Diagnosis Meta-analysis

作者简介: 罗金花（1987-），女，汉族，广东阳春人，博士，研究方向：衰老与内分泌代谢性疾病的关系。

引用本文:

罗金花；何来鹏；袁满. 糖化血清白蛋白对糖尿病诊断价值的meta分析[J]. 中国当代医药, 2021, 28(32): 23-27.
LUO Jin-hua；HE Lai-peng；YUAN Man. Meta-analysis of diagnostic value of glycosylated serum albumin in diabetes mellitus. 中国当代医药, 2021, 28(32): 23-27.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2021/V28/I32/23

[1]	Ikezaki H，Furusyo N，Ihara T，et al.Glycated albumin as a diagnostic tool for diabetes in a general Japanese population[J].Metabolism，2015，64（6）：698-705.
[2]	Wu WC，Ma WY，Wei JN，et al.Serum Glycated Albumin to Guide the Diagnosis of Diabetes Mellitus[J].PLoS One，2016，11（1）：e0146780.
[3]	Bellia C，Zaninotto M，Cosma C，et al.Clinical usefulness of Glycated Albumin in the diagnosis of diabetes：Results from an Italian study[J].Clin Biochem，2018，54：68-72.
[4]	Chume FC，Kieling MH，Correa Freitas PA，et al.Glycated albumin as a diagnostic tool in diabetes：An alternative or an additional test?[J].PLoS One，2019，14（12）：e0227065.
[5]	Zemlin AE，Barkhuizen M，Kengne AP，et al.Performance of glycated albumin for type 2 diabetes and prediabetes diagnosisin a South African population[J].Clin Chim Acta，2019，488：122-128.
[6]	Furusyo N，Koga T，Ai M，et al.Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study：results from the Kyushu and Okinawa Population Study （KOPS）[J].Diabetologia，2011，54（12）：3028-3036.
[7]	Ma XJ，Pan JM，Bao YQ，et al.Combined assessment of glycated albumin and fasting plasma glucose improves the detection of diabetes in Chinese subjects[J].Clin Exp Pharmacol Physiol，2010，37（10）：974-979.
[8]	Park S，Lee W，Chung HS，et al.Diagnostic Utility of Serum Glycated Albumin for Diabetes Mellitus and Its Correlation With Hyperlipidemia[J].Ann Lab Med，2016，36（4）：306-312.
[9]	Su H，Tang J，Ma X，et al.Postload Glycated Albumin as an Alternate Measure for Diabetes Screening in a Chinese Population[J].J Diabetes Res，2018，2018：7932528.
[10]	He X，Ying L，Ma X，et al.An additional measurement of glycated albumin can help prevent missed diagnosis of diabetes in Chinese population[J].Clin Chim Acta，2017，475：188-192.
[11]	张亭，何訸，杨惠岚，等.糖化血清白蛋白用于诊断糖尿病及糖调节异常的价值研究[J].四川大学学报（医学版），2014，45（2）：274-277，298.
[12]	陈祥吉，刘雅，张廷杰，等.糖尿病不同诊断指标临床意义探讨[J].内蒙古医科大学学报，2019，41（2）：193-195.
[13]	张希尧，王晶，崔璨，等.糖化血清白蛋白在2型糖尿病监测及诊断中的应用观察[J].临床内科杂志，2013，30（6）：384-386.
[14]	刘锐，谭秋娴，赖日辉，等.空腹血糖联合糖化血清白蛋白在2型糖尿病筛查中的应用价值研究[J].深圳中西医结合杂志，2014，24（11）：4-6，199.
[15]	张崇林.糖化血清白蛋白检测对糖尿病诊断的临床价值[J].中国医药导刊，2014，16（4）：722-723.
[16]	吕艳，王路长，夏汝杰，等.糖化血清白蛋白诊断糖尿病的价值研究[J].实用医院临床杂志，2016，13（4）：104-106.
[17]	朱长清，石凌波，康红.糖化血清白蛋白对糖尿病及糖尿病前期患者的临床诊断价值[J].微循环学杂志，2017，27（2）：59-61，66.
[18]	王冰.酶法检测糖化血清白蛋白的性能评价及临床应用研究[D].昆明：昆明医科大学，2016.
[19]	Lu L，Pu LJ，Xu XW，et al.Association of serum levels of glycated albumin，C-reactive protein and tumor necrosis factor-alpha with the severity of coronary artery disease and renal impairment in patients with type 2 diabetes mellitus[J].Clin Biochem，2007，40（11）：810-816.
[20]	Kobayashi H，Abe M，Yoshida Y，et al.Glycated Albumin versus Glycated Hemoglobin as a Glycemic Indicator in Diabetic Patients on Peritonea l Dialysis[J].Int J Mol Sci，2016，17（5）：619.
[21]	Shima K，Ito N，Abe F，et al.High-performance liquid chromatographic assay of serum glycated albumin[J].Diabetologia，1988，31（8）：627-631.