Abstract： Objective To study the application value of thin-cytologic test (TCT)+ human papilloma virus (HPV)+ squamous cell carcinoma antigen (SCC-Ag) combined detection in early screening of cervical cancer.Methods A total of 114 patients from May 2018 to May 2020 in the Fifth People′s Hospital of Jianli City, Hubei Province who tested by TCT, HPV and SCC-Ag were selected as the research objects.They were divided into cervical cancer group (38 cases),cervical benign tumor group (38 cases) and healthy control group (38 cases) according to the pathological results.The TCT, HPV and serum SCC-Ag of the three groups were detected.The receiver operating characteristic (ROC) was used to analyze the clinical value of single and combined detection of TCT, HPV and SCC-Ag in the diagnosis of cervical cancer.Results The positive rates of TCT, HPV and the level of SCC-Ag in serum in cervical cancer group were significant higher than those in benign tumor group and control group, the differences were statistically significant (P＜0.05).ROC showed that the TCT, HPV and SCC-Ag had certain application value in the diagnosis of cervical cancer.The area under the curve, sensitivity and specificity of TCT+HPV+SCC-Ag in the diagnosis of cervical cancer were 0.901, 0.921 and 0.882, respectively.Conclusion TCT+HPV+SCC-Ag combined detection is helpful to improve the diagnostic accuracy of cervical cancer, which can be used for early screening of cervical cancer.
黄丽. TCT+HPV+SCC-Ag联合检测在宫颈癌早期筛查中的应用价值[J]. 中国当代医药, 2021, 28(29): 181-184.
HUANG Li. Application value of TCT+HPV+SCC-Ag combined detection in early screening of cervical cancer. 中国当代医药, 2021, 28(29): 181-184.
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