体重指数对行体外受精/卵胞浆内单精子显微注射技术治疗患者人绒毛膜促性腺激素日激素水平的影响

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摘要目的探讨不孕女性在进行体外受精/卵胞浆内单精子显微注射技术（IVF/ICSI）治疗过程中，不同体重指数（BMI）对人绒毛膜促性腺激素（HCG）日血清雌二醇（E2）、促黄体生成素（LH）、孕酮（P）水平的影响。方法对滨州医学院附属医院行IVF/ICSI 治疗的1307 个周期进行回顾性分析。根据年龄的不同，将不孕女性分为年龄≤35 岁组和年龄＞35 岁组，根据BMI 的不同，将两组进一步分为三个亚组，即正常体重组（18.5 kg/m2≤BMI＜23 kg/m2）、超重组（23 kg/m2≤BMI＜25 kg/m2）和肥胖组（BMI≥25 kg/m2），观察不同BMI 对HCG日激素水平的影响。结果年龄≤35 岁组的不孕女性，正常体重组、超重组、肥胖组三个亚组的HCG日E2 水平比较，差异有统计学意义（P＜0.05）。肥胖组的E2 水平低于正常组和超重组，差异有统计学意义（P＜0.05）。三个亚组的HCG日P 水平比较，差异有统计学意义（P＜0.05）。肥胖组P 水平低于正常组和超重组，差异有统计学意义（P＜0.05）。三个亚组的HCG日LH比较，差异无统计学意义（P＞0.05），三个亚组的妊娠率比较，差异无统计学意义（P＞0.05）。年龄＞35 岁组的不孕女性，正常体重组、超重组、肥胖组三个亚组的HCG日P 水平比较，差异有统计学意义（P＜0.05）。正常组的P 水平高于超重组和肥胖组，差异有统计学意义（P＜0.05）；三个亚组的HCG日E2、LH 水平比较，差异无统计学意义（P＞0.05），三个亚组的妊娠率比较，差异无统计学意义（P＞0.05）。相关性分析结果显示，BMI 与HCG日E2、P 呈负相关（P＜0.05）；控制年龄因素后进行偏相关分析，结果显示BMI 与HCG日E2、P 成负相关（P＜0.05）。结论对于行IVF/ICSI 治疗的不孕女性，其HCG日血清E2、P 水平随BMI 的升高而降低，BMI 不影响HCG日血清LH 的水平，研究尚未发现BMI 会影响妊娠结局。

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关键词 ：体外受精/卵胞浆内单精子显微注射技术, 体重指数, 人绒毛膜促性腺激素日, 雌二醇, 促黄体生成素, 孕酮, 妊娠结局

Abstract：Objective To analyze the effect of the different body mass index (BMI) on estradiol (E2), luteinizing hormone (LH) and progesterone (P) values in females who received in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI) treatment on human chorionic gonadotropin (HCG) day. Methods A total of 1307 cycles of IVF/ICSI conducted in our reproductive center were retrospectively analyzed. Based on the age, female infertility patients were divided into the group of the age ≤35 years old and the group of the age ＞35 years old. Then based on the different BMI, the two groups were further divided into three subgroups: normal weight group (18.5 kg/m2≤BMI＜23 kg/m2),overweight group (23 kg/m2≤BMI＜25 kg/m2) and obese group (BMI≥25 kg/m2). The effect of BMI in different age groups on the hormone level of HCG day were observed. Results There were statistically significant differences in E2 levels of infertile women aged ≤35 years, normal weight group, overweight group and obese group (P＜0.05). The level of E2 in obese group was lower than that in normal group and overrecombinant group, and the difference was statistically significant (P＜0.05). The P level of HCG in the three subgroups was statistically significant (P＜0.05). The P level of obese group was lower than that of normal group and overreorganization group, and the difference was statistically significant (P＜0.05). There was no statistically significant difference in LH on HCG day among the three subgroups (P＞0.05), and there was no statistically significant difference in pregnancy rate among the three subgroups(P＞0.05). There was significant difference in HCG day P level among infertile women aged ＞35 years, normal weight group, overweight group and obese group (P＜0.05). The P level of normal group was higher than that of overweight and obesity group, the difference was statistically significant (P＜0.05). There was no significant difference in E2 and LH levels among the three subgroups on HCG day (P＞0.05), and there was no significant difference in pregnancy rate among the three subgroups (P＞0.05). Correlation analysis showed that BMI was negatively correlated with E2 and P on HCG day(P＜0.05). Partial correlation analysis after age control showed that BMI was negatively correlated with E2 and P on HCG day (P＜0.05). Conclusion For infertile women treated with IVF/ICSI, serum E2 and P levels on HCG day decreased with the increase of BMI, BMI does not affect serum LH level on HCG day, and BMI has not been found to affect pregnancy outcome.

Key words： In vitro fertilization/intracytoplasmic sperm injection Body mass index Human chorionic gonadotropin day Estradiol Luteinizing hormone Progesterone Pregnancy outcome

引用本文:

黄盈;劳凯雪;王雁林▲. 体重指数对行体外受精/卵胞浆内单精子显微注射技术治疗患者人绒毛膜促性腺激素日激素水平的影响[J]. 中国当代医药, 2022, 29(2): 24-28.
HUANG Ying; LAO Kaixue; WANG Yanlin▲. Effect of body mass index on hormone level of patients on human chorionic gonadotropin day with in vitro fertilization/intracytoplasmic sperm injection treatment. 中国当代医药, 2022, 29(2): 24-28.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2022/V29/I2/24

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