Clinical effect of Polyethylene Glycol Eye Drops combined with Recombinant Bovine Basic Fibroblast Growth Factor Eye Gel in the treatment of meibomian gland dysfunction xerophthalmia
KANG Bin WAN Jin-lan▲
Department of Ophthalmology,Jingmen Traditional Chinese Medicine Hospital,Hubei Province,Jingmen 448000,China
Abstract：Objective To investigate the clinical effect of Polyethylene Glycol Eye Drops combined with Recombinant Bovine Basic Fibroblast Growth Factor Eye Gel in the treatment of meibomian gland dysfunction（MGD）xerophthalmia.Methods A total of 311 cases (622 eyes) of MGD patients with xerophthalmia who visited the outpatient department of Jingmen Traditional Chinese Medicine Hospital from April 2018 to July 2019 were selected as the research subjects.According to the random drawing method, the patients were divided into the observation group (160 cases, 320 eyes)and the control group (151 cases, 302 eyes).Two groups were treated with Recombinant Bovine Basic Fibroblast Growth Factor Eye Gel of conductance treatment, and the meibomian gland was mechanical dredged.The observation group was treated with Polyethylene Glycol Eye Drops 4 times/d, and the control group was treated with Polyethylene Glycol Eye Drops every other day.The patients′ self-conscious symptom score, Schirmer Ⅰtest (SⅠT), tear film rupture time(BUT), corneal fluorescein staining score and lipid trait score were compared between the two groups.Results There were no significant differences in BUT, corneal fluorescein staining and conscious symptom scores between the two groups before treatment (P>0.05).After treatment, BUT in the observation group was longer than that in the control group, and the corneal fluorescein staining and conscious symptom score in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).After treatment, lipid trait scores of the two groups were lower than those before treatment, and the difference was statistically significant (P＜0.05).There was no significant difference in SⅠT between the two groups before and after treatment (P>0.05).There were no obvious adverse reactions in the two groups during the process of the treatment.Conclusion The clinical effect of standard Polyethylene Glycol Eye Drops combined with Recombinant Bovine Basic Fibroblast Growth Factor Eye Gel for the treatment of eyelid gland dysfunction type xerophthalmopathy is better and has high safety.
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